Genomic alterations and molecular diversity of chimeric genes in hematologic malignancies
Project/Area Number |
24591407
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
TAKI Tomohiko 京都府立医科大学, 医学(系)研究科(研究院), 講師 (50322053)
|
Co-Investigator(Kenkyū-buntansha) |
KAWAMURA Machiko 公益財団法人東京都医学研究所, 研究員 (80450592)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | がん / ゲノム / キメラ遺伝子 / 非コード遺伝子 / リボゾーム遺伝子 / PVT1 / NSMCE2 / RNAシーケンス / RN28S1 / BCL11B / IGK / COG1 / キメラ転写産物 |
Outline of Final Research Achievements |
Noncoding gene, PVT1 was frequently rearranged in multiple myeloma, and the PVT1-WWOX was identified in RPMI8226 cell line. We further identified another fusion transcript of PVT1, PVT1-NSMCE2, in acute myeloid leukemia (AML) having highly genomic amplification with 8q24. Novel fusion partner of PVT1, NSMCE2, also created BF104016-NSMCE2 fusion transcript in an AML cell line. On the other hand, we identified another type of fusion transcript involving ribosomal DNA. Three fusion transcripts involving RN28S1 were identified in T-cell acute lymphoblastic leukemia, Burkitt lymphoma, and multiple myeloma, respectively. Further analysis is needed to clarify the role of these novel types of fusion transcript in tumorigenesis.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia.2014
Author(s)
Chinen Y, Sakamoto N, Nagoshi H, Taki T, Maegawa S, Tatekawa S, Tsukamoto T, Mizutani S, Shimura Y, Yamamoto-Sugitani M, Kobayashi T, Matsumoto Y, Horiike S, Kuroda J, Taniwaki M.
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Journal Title
J Hematol Oncol
Volume: 7
Issue: 1
Pages: 68-68
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] EVI1 overexpression is a poor prognostic factor in pediatric patients with mixed lineage leukemia-AF9 rearranged acute myeloid leukemia.2014
Author(s)
Matsuo H, Kajihara M, Tomizawa D, Watanabe T, Saito AM, Fujimoto J, Horibe K, Kodama K, Tokumasu M, Itoh H, Nakayama H, Kinoshita A, Taga T, Tawa A, Taki T, Shiba N, Ohki K, Hayashi Y, Yamashita Y, Shimada A, Tanaka S, Adachi S.
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Journal Title
Haematologica
Volume: 99
Issue: 11
Pages: 225-227
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group.2014
Author(s)
Matsuo H, Kajihara M, Tomizawa D, Watanabe T, Saito AM, Fujimoto J, Horibe K, Kodama K, Tokumasu M, Itoh H, Nakayama H, Kinoshita A, Taga T, Tawa A, Taki T, Tanaka S, Adachi S.
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Journal Title
Blood Cancer J
Volume: 4
Issue: 7
Pages: e226-e226
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.2014
Author(s)
Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, Manachai N, Yamakawa N, Hamasaki M, Kitabayashi I, Arai Y, Kanai Y, Taki T, Abe T, Kiyonari H, Shimoda K, Ohshima K, Horii A, Shima H, Taniwaki M, Yamaguchi R, Morishita K.
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Journal Title
Nat Commun
Volume: in press
Issue: 1
Pages: 3393-3393
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic impact of gained chromosomes in high-hyperdiploid childhood acute lymphoblastic leukaemia2014
Author(s)
Kato M, Imamura T, Manabe A, Hashii Y, Koh K, Sato A, Takahashi H, Hori H, Taki T, Inoue M, Hayashi Y, Horibe K, Tsuchida M, Kojima S, Oda M, Ohara A .
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Journal Title
Br J Haematol
Volume: 166
Issue: 2
Pages: 295-298
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of novel fusion genes with 28S ribosomal DNA in hematologic malignancies.2014
Author(s)
Kobayashi S, Taki T, Nagoshi H, Chinen Y, Yokokawa Y, Kanegane H, Matsumoto Y, Kuroda J, Horiike S, Nishida K, Taniwaki M.
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Journal Title
Int J Oncol
Volume: 44
Issue: 4
Pages: 1193-1198
DOI
Related Report
Peer Reviewed
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[Journal Article] The leucine twenty homeobox (LEUTX) gene, which lacks a histone acetyltransferase domain, is fused to KAT6A in therapy-related AML with t(8;19)(p11;q13).2014
Author(s)
Chinen Y, Taki T, Tsutsumi Y, Kobayashi S, Matsumoto Y, Sakamoto N, Kuroda J, Horiike S, Nishida K, Ohno H, Uike N, Taniwaki M.
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Journal Title
Genes Chromosomes Cancer
Volume: 53
Issue: 4
Pages: 299-308
DOI
Related Report
Peer Reviewed
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[Journal Article] WT1 mutation in pediatric patients with acute myeloid leukemia: A study of the Japanese Childhood AML Cooperative Study Group2013
Author(s)
Sano H, Shimada A, Tabuchi K, Taki T, Murata C, Park M, Sotomatsu Tawa A, Kobayashi R, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y
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Journal Title
Int J Hematol
Volume: 98
Issue: 4
Pages: 437-445
DOI
Related Report
Peer Reviewed
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[Journal Article] CD56 expression is an independent prognostic factor for relapse in acute myeloid leukemia with t(8;21).2013
Author(s)
Iriyama N, Hatta Y, Takeuchi J, Ogawa Y, Ohtake S, Sakura T, Mitani K, Ishida F, Takahashi M, Maeda T, Izumi T, Sakamaki H, Miyawaki S, Honda S, Miyazaki Y, Taki T, Taniwaki M, Naoe T.
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Journal Title
Leuk Res
Volume: 37
Issue: 9
Pages: 1021-1026
DOI
Related Report
Peer Reviewed
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[Journal Article] Deletion or methylation of CDKN2A/2B and PVT1 rearrangement occur frequently in highly aggressive B-cell lymphomas harboring 8q24 abnormality.2013
Author(s)
Tsutsumi Y, Chinen Y, Sakamoto N, Nagoshi H, Nishida K, K, Yokokawa Y, Taki T, Sasaki N, Yamamoto-Sugitani M, Kobayashi T, Matsumoto Y, Horiike S, Kuroda J, Taniwaki M
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] NUP98-NSD1 related gene expression signature is strongly associated with a poor prognosis in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group Cooperative Study Group2013
Author(s)
Shiba N, Ichikawa H, Taki T, Park M, Jo A, Mitani S, Shimada A, Sotomatsu M, Arakawa H, Tabuchi K, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y
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Journal Title
Genes Chromosomes Cancer
Volume: 52
Issue: 7
Pages: 683-693
DOI
Related Report
Peer Reviewed
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[Journal Article] High WT1 mRNA expression after induction chemotherapy and FLT3-ITD have prognostic impact in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group2012
Author(s)
Shimada A, Taki T, Koga D, Tabuchi K, Tawa A, Hanada R, Tsuchida M, Horibe K, Tsukimoto I, Adachi S, Kojima S, Hayashi Y
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Journal Title
Int J Hematol
Volume: 96
Issue: 4
Pages: 469-476
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Frequent PVT1 rearrangement and novel chimeric genes PVT1-NBEA and PVT1-WWOX occur in multiple myeloma with 8q24 abnormality.2012
Author(s)
Nagoshi H, Taki T, Hanamura I, Nitta M, Otsuki T, Nishida K, Okuda K, Sakamoto N, Kobayashi S, Yamamoto-Sugitani M, Tsutsumi Y, Kobayashi T, Matsumoto Y, Horiike S, Kuroda J, Taniwaki M
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Journal Title
Cancer Res
Volume: 72
Pages: 4954-4962
Related Report
Peer Reviewed
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[Presentation] PVT1-NSMCE2 fusion gene enhances BCL-XL expression and drug resistance in leukemic cells.2014
Author(s)
Yoshiaki Chinen, Natsumi Sakamoto, Hisao Nagoshi, Tomohiko Taki, Satoru Kobayashi, Kazuhiro Nishida, Saori Maegawa, Miki Kiyota, Shinsuke Mizutani, Yuji Shimura, Mio Sugitani, Tsutomu Kobayashi, Yosuke Matsumoto, Shigeo Horiike, Junya Kuroda, Masafumi Taniwaki
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪
Year and Date
2014-10-31 – 2014-11-02
Related Report
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[Presentation] The prognostic impact of high EVI1-related genes expression in pediatric acute myeloid leukemia.2014
Author(s)
Norio Shiba, Yusuke Hara, Kentaro Ohki, Genki Yamato, Myoung-Ja Park, Tohru Kobayashi, Hitoshi Ichikawa, Daisuke Tomizawa, Tomohiko Taki, Akira Shimada, Manabu Sotomatsu, Hirokazu Arakawa, Keizo Horibe, Souichi Adachi, Akio Tawa, Yasuhide Hayashi
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪
Year and Date
2014-10-31 – 2014-11-02
Related Report
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[Presentation] Successful treatment of congenital AML with t(8;16)(p11;p13) by minimal chemotherapy.2013
Author(s)
Kagehiro Kozuki, Itaru Kato, Tomoo Daifu, Katsutsugu Umeda, Hidefumi Hiramatsu, Ken-Ichiro Watanabe, Ichiro Kamiy, Tomohiko Taki, Tatsutoshi Nakahata, Toshio Heike, Souichi Adachi.
Organizer
第75回日本血液学会学術集会
Place of Presentation
札幌
Related Report
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[Presentation] A diversity of cases in AML with promyelocytic differentiation: A report from JPLSG.2013
Author(s)
Hiroyuki Takahashi, Hiromichi Matsushita, Akitoshi Kinoshita, Tomohiko Taki, Takao Deguchi, Nobutaka Kiyokawa, Yoshiko Hashii, Yasuhide Hayashi, Daisuke Tomizawa, Takashi Taga, Akio Tawa, Soichi Adachi, Miharu Yabe, Hayao Miyachi.
Organizer
第75回日本血液学会学術集会
Place of Presentation
札幌
Related Report
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[Presentation] Chemotherapy prior to HSCT is beneficial for pediatric TAEB/RAEB-T.2013
Author(s)
Akira Shimada, Akitoshi Kinoshita, Atsushi Manabe, Miharu Yabe, Hayato Miyachi, Hiromichi Matsushita, Tomohiko Taki, Masami Inoue, Daisuke Hasegawa, Asahito Hama, Masafumi Ito, Akio Tawa, Seiji Kojima, Souichi Adachi.
Organizer
第75回日本血液学会学術集会
Place of Presentation
札幌
Related Report
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[Presentation] Clonal heterogeneity and evolution of acute myeloid leukemia during disease progression.2013
Author(s)
Rika Kihara, Hideaki Hoshino, Kotaro Suzuki, Fangli Chen, Takahiro Kato, Syuichi Miyawaki, Norio Asou, Tomohiko Taki, Masafumi Taniwaki, Tomoki Naoe, Hitoshi Kiyoi.
Organizer
第75回日本血液学会学術集会
Place of Presentation
札幌
Related Report
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[Presentation] NUP98-NSD1 gene fusion is a strong poor prognostic factor in pediatric AML.2013
Author(s)
Yusuke Hara, Norio Shiba, Hitoshi Ichikawa, Tomohiko Taki, Akira Shimada, Kauko Kudo, Daisuke Tomizawa, Takashi Taga, Souichi Adachi, Hirokazu Arakawa, Akio Tawa, Yasuhide Hayashi.
Organizer
第75回日本血液学会学術集会
Place of Presentation
札幌
Related Report
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[Presentation] Double investigation of the clinical significance of CEBPA mutation in child AML: The JPLSG AML-05 study.2013
Author(s)
Hidemasa Matsuo, Mio Kajihara, Daisuke Tomizawa, Tomoyuki Watanabe, Akiko Moriya Saito, Junichiro Fujimoto, Keizo Horibe, Mayu Tokumasu, Hiroshi Itoh, Hideki Nakayama, Akitoshi Kinoshita, Takashi Taga, Akio Tawa, Tomohiko Taki, Souichi Adachi.
Organizer
第75回日本血液学会学術集会
Place of Presentation
札幌
Related Report
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[Presentation] Novel chimeric gene of PVT1 with WWOX in multiple myeloma with 8q24 abnormality.2012
Author(s)
Nagoshi H, Taki T, Nishida K, Sakamoto N, Kuroda J, Kobayashi S, Chinen Y, Yokokawa Y, Sugitani M, Kobayashi T, Matsumoto Y, Horiike S, Taniwaki M
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Related Report
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[Presentation] Identification of novel fusion genes with 28S ribosomal DNA in hematologic malignancies.2012
Author(s)
Satoru Kobayashi, Tomohiko Taki, Hisao Nagoshi, Yoshiaki Chinen, Yuichi Yokokawa, Hirokazu Kanegane, Yosuke Matsumoto, Junya Kuroda, Shigeo Horiike, Kazuhiro Nishida, Masafumi Taniwaki
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Related Report
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[Presentation] Identification of the Novel Chimeric Gene, PVT1-WWOX, in Multiple Myeloma with 8q24 Abnormality2012
Author(s)
Nagoshi H, Taki T, Nishida K, Kuroda J, Chinen Y, Kobayashi S, Yokokawa Y, Yamamoto-Sugitani M, Kobayashi T, Matsumoto Y, Horiike S, Taniwaki M
Organizer
54th Annual Meeting of the American Society of Hematology
Place of Presentation
Atlanta
Related Report