The pathogenesis of acute myeloid leukemia due to the CAP1 gene mutation.
Project/Area Number |
24591412
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Nippon Medical School |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
|
Keywords | CAP1 / 急性骨髄性白血病 / 遺伝子変異 / CAP1 |
Outline of Final Research Achievements |
We screened for CAP1 mutations on 200 initial presentation cases and 30 relapsed cases with acute myeloid leukemia (AML). In initial presentation subject samples, mutations were observed in one case (missense mutation), and in relapsed subject samples, mutations were observed in 3 cases (Nonsence mutation 1case, micro-insertion 2cases).We analyzed a function of the CAP1 mutation in vitro. In wild type, localization varied from cytoplasm to mitochondria by apoptotic instruction, but mutant type did not move from cytoplasm. It was found that wild/mutant type(1:1) did not induce the apoptosis that was lower than half as compared with wild type. Also mutant type did not induce the apoptosis that was lower than 1/5 as compared with wild type.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Granulocyte colony-stimulating factor combined regimen in cord blood transplantation for acute myeloid leukemia: a nationwide retrospective analysis in Japan.2014
Author(s)
1.Konuma T, Ooi J, Uchida N, Ogawa H, Ohashi K, Kanamori H, Aotsuka N, Onishi Y, Yamaguchi H, Kozai Y, Nagamura-Inoue T, Kato K, Suzuki R, Atsuta Y, Kato S, Asano S, Takahashi S.
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Journal Title
Haematologica
Volume: 99(12)
Issue: 12
Pages: e264-e268
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mutations of the Epigenetics Modifying Gene (DNMT3a, TET2, IDH1/2) at Diagnosis may Induce FLT3-ITD at Relapse in de novo Acute Myeloid Leukemia.2013
Author(s)
Wakita S, Yamaguchi H Omori I, Terada K, Ueda T, Manabe E, Kurosawa S, Iida S, Ibaraki T, Sato Y, Todoroki T, Hirakawa T, Ryotokuji T, Arai K, Kitano T, Mitamura Y, Kosaka F, Dan K, Inokuchi K.
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Journal Title
Leukemia.
Volume: 27(5)
Pages: 1044-1052
Related Report
Peer Reviewed
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[Presentation] The prognostic and clinical feature of HSCT patients with chemotherapy refractory acute myeloid leukemia2015
Author(s)
Keiko Fukunaga, Hiroki Yamaguchi, Yusuke Fujiwara, Shunsuke Yui, Takeshi Ryotokuji, Tsuneaki Hirakawa, Masahiro Okabe, Satoshi Wakita, Hayato Tamai, Muneo Okamoto, Kazutaka Nakayama, Koiti Inokuchi
Organizer
第37回 日本造血細胞移植学会総会
Place of Presentation
神戸
Year and Date
2015-03-05 – 2015-03-07
Related Report
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[Presentation] The prognostic impact of cytogenetic and genetic abnormality for the achievement of the second complete remission in adult patients with acute myeloid leukemia2014
Author(s)
Keiko Fukunaga, Hiroki Yamaguchi, Satoshi Wakita, Ikuko Omori, Shunsuke Yui, Takeshi Ryotokuji, Tsuneaki Hirakawa, Kunihito Arai, Tomoaki Kitano, Fumiko Kosaka, Koiti Inokuchi
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪
Year and Date
2014-10-31 – 2014-11-02
Related Report
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[Presentation] The clinical features and prognostic impact of acute myeloid leukemia with Epigenetics Modifying Gene mutation2014
Author(s)
Anna Kobayashi, Hiroki Yamaguchi, Kensuke Usuki, Yutaka Kobayashi, Kenji Tajika, Gomi Seiji, Makoto Watanabe, Kentaro Azuma, Yuko Sato, Takahiro Todoroki, Ikuko Omori, Fukunaga Keiko, Satoshi Wakita, Tsuneaki Hirakawa, Takeshi Ryotokuji, Kunihito Arai, Tomoaki Kitano1, Fumiko Kosaka, Hayato Tamai, Koiti Inokuchi
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪
Year and Date
2014-10-31 – 2014-11-02
Related Report
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[Presentation] The clinical features and prognostic impact of de novo acute myeloid leukemia with WT1mutation2014
Author(s)
Makoto Watanabe, Hiroki Yamaguchi, Kensuke Usuki, Yutaka Kobayashi, Kenji Tajika, Seiji Gomi, Anna Kobayashi, Kentaro Azuma, Yuko Sato, Takahiro Todoroki, Ikuko Omori, Fukunaga Keiko, Satoshi Wakita, Tsuneaki Hirakawa, Takeshi Ryotokuji, Kunihito Arai, Tomoaki Kitano, Fumiko Kosaka, Hayato Tamai, Koiti Inokuchi
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪
Year and Date
2014-10-31 – 2014-11-02
Related Report
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[Presentation] The prognostic impact of cytogenetic and genetic abnormality for the achievement of the second complete remission in adult patients with acute myeloid leukemia after first relapse2014
Author(s)
Keiko Fukunaga, Hiroki Yamaguchi, Satoshi Wakita, Ikuko Omori, Shunsuke Yui, Takeshi Ryotokuji, Tsuneaki Hirakawa, Kunihito Arai, Tomoaki Kitano, Fumiko Kosaka, Kazuo Dan, Koiti Inokuchi.
Organizer
19th. European Hematology Association
Place of Presentation
Milan, Italy
Year and Date
2014-06-12 – 2014-06-15
Related Report
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[Presentation] The prognostic impact of cytogenetic and genetic abnormality for the achievement of the second complete remission in adult patients with acute myeloid leukemia2014
Author(s)
Keiko Fukunaga, Hiroki Yamaguchi, Satoshi Wakita, Ikuko Omori, Shunsuke Yui, Takeshi Ryotokuji, Tsuneaki Hirakawa, Kunihito Arai, Tomoaki Kitano, Fumiko Kosaka, Kazuo Dan, Koiti Inokuchi
Organizer
The 6th JSH International Symposium
Place of Presentation
浜松
Year and Date
2014-05-23 – 2014-05-24
Related Report
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[Presentation] The clinical features and prognostic impact of DNMT3A gene mutation in Japanese patients with de novo AML2012
Author(s)
Ryotokuji T, Yamaguchi H, Omori I, Hirakawa T, Wakita S, Arai K, Kitano T, Mitamura Y, Kosaka F, Shimada T, Inokuchi K, Dan K.
Organizer
The 3rd JSH International Symposium
Place of Presentation
Kawagoe
Related Report
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[Presentation] The clinical features and prognostic impact of DNMT3A gene mutation in Japanese patients with de novo AML2012
Author(s)
Wakita S, Yamaguchi H, Ryotokuji T, Takeuchi J, Omori I, Hirakawa T, Kitano T, Mitamura Y, Kosaka F, Inokuchi K, Dan K.
Organizer
17th congress of the European hematology Association
Place of Presentation
Amsterdam, Netherlands
Related Report
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[Presentation] The clinical features and prognostic impact of DNMT3A gene mutation in Japanese patients with de novo AML2012
Author(s)
Ryotokuji T, Yamaguchi H, Usuki K, Tajika K, Gomi S, Omori I, Sato Y, Todoroki T, Arai K, Kitano T, Mitamura Y, Kosaka F, Hirakawa T, Wakita S, Inokuchi K, Dan K.
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Related Report
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[Presentation] The clinical features and prognostic impact of de novo acute myeloid leukemia with MLL-PTD2012
Author(s)
Todoroki T, Yamaguchi H, Usuki K, Tajika K, Gomi S, Omori I, Sato Y, Arai K, Kitano T, Mitamura Y, Kosaka F, Ryotokuji T, Hirakawa T, Wakita S, Inokuchi K, Dan K
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Related Report
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[Presentation] The clinical features and prognostic impact of de novo acute myeloid leukemia with RAS mutation2012
Author(s)
Sato Y, Yamaguchi H, Usuki K, Tajika K, Gomi S, Omori I, Todoroki T, Arai K, Kitano T, Mitamura Y, Kosaka F, Ryotokuji T, Hirakawa T, Wakita S, Inokuchi K, Dan K.
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Related Report
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[Presentation] The prognostic impact of Flt3 mutation in acute promyelocytic leukemia2012
Author(s)
Hirakawa T, Yamaguchi H, Wakita S, Ryotokuji T, Kosaka F, Kitano T, Arai K, Omori I, Sato Y, Todoroki T, Dan K, Inokuchi K.
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Related Report
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[Presentation] エピジェネティクス制御遺伝子変異は急性骨髄性白血病の多様な遺伝子変異の出現に寄与する.
Author(s)
脇田知志, 山口博樹, 了徳寺剛, 平川経晃, 大森郁子, 北野智章, 荒井邦仁, 三田村佳勇, 小坂文子, 檀 和夫, 猪口孝一.
Organizer
第109回日本内科学会総会
Place of Presentation
東京
Related Report
Invited
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[Presentation] Comprehensive gene mutation analyses in acute myeloid leukemia: overlap of the gene mutations are important for the prognosis of the intermediate risk karyotype group.
Author(s)
Wakita S, Yamaguchi H, Ryotokuji T, Hirakawa T, Omori I, Kitano T, Arai K, Kosaka F, Dan K, Inokuchi K.
Organizer
18th. European Hematology Association.
Place of Presentation
Stockholm, Sweden
Related Report
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[Presentation] The prognostic impact of complex gene mutation in the intermediate risk karyotype AML.
Author(s)
Wakita S, Yamaguchi H, Usuki K, Kobayashi Y, Gomi S, Tajika K, Hirakawa T, Ryotokuji T, Azuma K, Sato Y, Todoroki T, Omori I, Fukunaga K, Arai K, Kitano T, Kosaka F, Dan K, Inokuchi K.
Organizer
第75回日本血液学会.
Place of Presentation
札幌
Related Report
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[Presentation] The clinical feature and prognostic impact of de novo acute myeloid leukemia with Runx1 mutation.
Author(s)
Azuma K, Yamaguchi H, Usuki K, Kobayashi Y, Tajika K, Gomi S, Sato Y, Todoroki T, Omori I, Fukunaga K, Wakita S, Hirakawa T, Ryotokuji T, Arai K, Kitano T, Kosaka F, Dan K, Inokuchi K.
Organizer
第75回日本血液学会.
Place of Presentation
札幌
Related Report
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[Presentation] The prognostic impact of additional gene mutations among intermediate risk AML with CEBPA and NPM1.
Author(s)
Fukunaga K, Yamaguchi H, Wakita S, Usuki K, Kobayashi Y, Gomi S, Tajika K, Ryotokuji T, Hirakawa T, Azuma K, Sato Y, Todoroki T, Omori I, Arai K, Kitano T, Kosaka F, Dan K, Inokuchi K.
Organizer
第75回日本血液学会.
Place of Presentation
札幌
Related Report
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[Presentation] The Prognostic Impact Of Complex Gene Mutation In The Intermediate Risk Karyotype Acute Myeloid Leukemia.
Author(s)
Satoshi Wakita, Hiroki Yamaguchi, Takeshi Ryotokuji, Tuneaki Hirakawa, Ikuko Omori, Tomoaki Kitano, Kunihito Arai, Yoshio Mitamura, Fumiko Kosaka, Kazuo Dan, and Koiti Inokuchi.
Organizer
55rd American Society of Hematology
Place of Presentation
New Orleans, LA, USA
Related Report
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