Renin-angiotensin system and non-infectious pulmonary complication after stem cell transplantation

Research Project

Project/Area Number	24591431
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Hematology
Research Institution	Tokai University
Principal Investigator	ONIZUKA MAKOTO 東海大学, 医学部, 講師 (80366012)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000) Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords	造血幹細胞移植 / 移植後肺合併症 / レニン・アンジオテンシン系 / マウス肺合併症モデル / 非感染性移植後肺合併症 / 移植片対宿主病 / 造血幹細胞移植学
Outline of Final Research Achievements	Angiotensin 1 receptor antagonist may be a candidate drug for prevent developing non-infectious pulmonary complication after hematopoietic stem cell transplantation. However, in mice transplantation model, we could not see survival benefit by AT1 receptor antagonist. But AT1 receptor antagonist reduces the incident of mice pulmonary fibrosis in the model.

Report

(4 results)