Renin-angiotensin system and non-infectious pulmonary complication after stem cell transplantation
Project/Area Number |
24591431
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Tokai University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | 造血幹細胞移植 / 移植後肺合併症 / レニン・アンジオテンシン系 / マウス肺合併症モデル / 非感染性移植後肺合併症 / 移植片対宿主病 / 造血幹細胞移植学 |
Outline of Final Research Achievements |
Angiotensin 1 receptor antagonist may be a candidate drug for prevent developing non-infectious pulmonary complication after hematopoietic stem cell transplantation. However, in mice transplantation model, we could not see survival benefit by AT1 receptor antagonist. But AT1 receptor antagonist reduces the incident of mice pulmonary fibrosis in the model.
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Report
(4 results)
Research Products
(1 results)
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[Journal Article] ACE deletion polymorphism is associated with a high risk of non-infectious pulmonary complications after stem cell transplantation.2014
Author(s)
Mitsuki Miyamoto, Makoto Onizuka, Shinichiro Machida, Masako Toyosaki, Jun Amaki, Yasuyuki Aoyama, Hidetsugu Kawai, Ai Sato, Naoki Hayama, Yoshiaki Ogawa, Hiroshi Kawada, Kiyoshi Ando
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Journal Title
International Jornal of Hematology
Volume: 99
Issue: 2
Pages: 175-175
DOI
Related Report
Peer Reviewed