Analysis of mechanism of successful HLA-haploidentical stem cell transplantation

• Project/Area Number: 24591434
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Hyogo Medical University
• Principal Investigator: OGAWA Hiroyasu 兵庫医科大学, 医学部, 教授 (80194447)
• Co-Investigator(Kenkyū-buntansha): OKADA Masaya 兵庫医科大学, 医学部, 講師 (00309452) ; KAIDA Katuzi 兵庫医科大学, 医学部, 助教 (00441254) ; IKEGAME Kazuhiro 兵庫医科大学, 医学部, 講師 (20372609) ; INOUE Takayuki 兵庫医科大学, 医学部, 助教 (20441256)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 造血幹細胞移植 / HLA半合致移植 / 移植片対宿主病 / 可溶性IL-2受容体 / 白血病 / 制御性T細胞 / 移植片対白血病効果 / 同種骨髄移植 / GVL / GVHD

Outline of Final Research Achievements

We developed a new regimen for unmanipulated HLA-haploidentical stem cell transplantation using reduced intensity conditioning, low dose of anti-thymocyte globulin and steroids. As graft-versus-host disease is a major drawback in haploidentical transplantation, we found that soluble interleukin-2 receptor level on day 7 was important as a predictor of graft-versus-host disease. In a prospective multicenter trial, the rate of donor engraftment and survival on day 100 was 100% and 88.2%, respectively. These data showed that this regimen was safe and feasible.
To study cellular mechanisms of haploidentical transplantation, we independently developed a murine MHC-haploidentical stem cell transplantation model, and studied the kinetics of immune cells in mesenteric lymph nodes early in transplantation. As a result, host-derived regulatory T cells were found to negatively regulate host dendritic cells, resulting in inducing the tolerance between donor and recipients.

Research Products

• [Journal Article] Unmanipulated haploidentical RIST using fludarabine, busulfan, low-dose ATG and steroid for patients in non-CR or at high risk of relapse: a prospective multicenter phase I/II study in Japan (2015)
  • Author(s): Ikegame K, Yoshida T, Yoshihara S, T Daimon, Shimizu H, Maeda Y, Ueda Y, Kaida K, Ishii S, Taniguchi K, Okada M, Tamaki H, Okumura H, Kaya H, Kurokawa T, Kodera Y, Taniguchi S, Kanda Y, Ogawa H.
  • Journal Title: Biology of Blood and Marrow Transplantation Volume: 未定 Issue: 8 Pages: 1495-1505
  • DOI: 10.1016/j.bbmt.2015.04.012
  • Peer Reviewed
• [Journal Article] Pretransplant diabetes mellitus is a risk factor for infection-related mortality, after allogeneic hematopoietic stem cell transplantation. (2015)
  • Author(s): Fuji S, Takano K, Uchida N, Ogawa H, Ohashi K, Eto T, Sakamaki H, Morishima Y, Kato K, Suzuki R, Fukuda T
  • Journal Title: Bone Marrow Transplantation Volume: 50 Issue: 4 Pages: 553-558
  • DOI: 10.1038/bmt.2014.315
  • Peer Reviewed
• [Journal Article] Prospectively isolated human bone marrow cell-derived MSCs support primitive human CD34-negative hematopoietic stem cells (2015)
  • Author(s): Matsuoka Y, Nakatsuka R, Sumide K, Kawamura H, Takahashi M, Fujioka T, Uemura Y, Asano H, Sasaki Y, Inoue M, Ogawa H, Takahashi T, Hino M, Sonoda Y
  • Journal Title: Stem Cells Volume: 33 Issue: 5 Pages: 1554-1565
  • DOI: 10.1002/stem.1941
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Fatal reactivation of hepatitis B virus infection in a patient with adult T-cell leukemia-lymphoma receiving the anti-CC chemokine receptor 4 antibody mogamulizumab. (2015)
  • Author(s): Ifuku H, Kusumoto S, Tanaka Y, Totani H, Ishida T, Okada M, Murakami S, Mizokami M, Ueda R, Iida S.
  • Journal Title: Hepatol Res. Volume: in press Issue: 13 Pages: 1363-1367
  • DOI: 10.1111/hepr.12513
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A phase 1/2 study of bosutinib in Japanese adults with Philadelphia chromosome-positive chronic myeloid leukemia (2015)
  • Author(s): Nakaseko C, Takahashi N, Ishizawa K, Kobayashi Y, Ohashi K, Nakagawa Y, Yamamoto K, Miyamura K, Taniwaki M, Okada M, Kawaguchi T, Shibata A, Fujii Y, Ono C, Ohnishi K
  • Journal Title: International Journal of Hematology Volume: 101 Issue: 2 Pages: 154-164
  • DOI: 10.1007/s12185-014-1722-8
  • Peer Reviewed
• [Journal Article] A Single high-resolution HLA mismatch has a similar adverse impact on the outcome of related hematopoietic stem cell transplantation as a single low-resolution HLA mismatch. (2015)
  • Author(s): Fuji S, Kanda J, Kato S, Ikegame K, Morishima S, Miyamoto T, Hidaka M, Kubo K, Miyamura K, Tsudo M, Kobayashi H, Maesako Y, Eto T, Adachi S, Ichinohe T, Atsuta Y, Kanda Y.
  • Journal Title: Am J Hematol Volume: 未定 Issue: 7 Pages: 618-623
  • DOI: 10.1002/ajh.24028
  • Peer Reviewed
• [Journal Article] Soluble interleukin-2 receptor level on day 7 as a predictor of graft-versus-host disease after HLA-haploidentical stem cell transplantation using reduced intensity conditioning. (2014)
  • Author(s): Kaida K, Ikegame K, Ikemoto J, Murata R, Irie R, Yoshihara S, Ishii S, Okada M, Inoue T, Tamaki H, Soma T, Fujimori Y, Kai S, Ogawa H.
  • Journal Title: International Journal of Hematology Volume: 99 Issue: 4 Pages: 463-470
  • DOI: 10.1007/s12185-014-1542-x
  • Peer Reviewed
• [Journal Article] Risk factors and organ involvement of chronic graft-versus-host disease in Japan. (2014)
  • Author(s): Kanda J, Nakasone H, Atsuta Y, Toubai T, Yokoyama H, Fukuda T, Taniguchi S, Ohashi K, Ogawa H, Eto T, Miyamura K, Morishima Y, Nagamura-Inoue T, Sakamaki H, Murata M.
  • Journal Title: Bone Marrow Transplantation Volume: 49 Issue: 2 Pages: 228-235
  • DOI: 10.1038/bmt.2013.151
  • Peer Reviewed
• [Journal Article] Allogeneic transplantation for primary myelofibrosis with bone marrow, peripheral blood, or umbilical cord blood: An analysis of the JSHCT. (2014)
  • Author(s): Murata M, Nishida T, Taniguchi S, Ohashi K, Ogawa H, Fukuda T, Mori T, Kobayashi H, Nakaseko C, Yamagata N, Morishima Y, Nagamura-Inoue T, Sakamaki H, Atsuta Y, Suzuki R, Naoe T.
  • Journal Title: Bone Marrow Transplantation Volume: 49 Issue: 3 Pages: 355-360
  • DOI: 10.1038/bmt.2013.180
  • Peer Reviewed
• [Journal Article] Comparison of angiogenic, cytoprotective, and immunosuppressive properties of human amnion- and chorion-derived mesenchymal stem cells. (2014)
  • Author(s): Yamahara K, Harada K, Ohshima M, Ishikane S, Ohnishi S, Tsuda H, Otani K, Taguchi A, Soma T, Ogawa H, Katsuragi S, Yoshimatsu J, Harada-Shiba M, Kangawa K, Ikeda T.
  • Journal Title: PLoS One. 2014 Feb 14;9(2):e88319. Volume: 9 Issue: 2 Pages: e88319-e88319
  • DOI: 10.1371/journal.pone.0088319
  • NAID: 40020640332
  • Peer Reviewed / Open Access
• [Journal Article] Recombinant human soluble thrombomodulin attenuates FK506- induced endothelial dysfunction through prevention of Akt inactivation. (2014)
  • Author(s): Eguchi R, Fujimori Y, Okada M, Tamaki H, Wakabayashi I, Ogawa H.
  • Journal Title: Experimental Cell Research Volume: 323 Issue: 1 Pages: 112-117
  • DOI: 10.1016/j.yexcr.2014.02.023
  • Peer Reviewed
• [Journal Article] Outcome of allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia patients with central nervous system involvement (2014)
  • Author(s): Aoki, J., Ishiyama, K., Taniguchi, S., Fukuda, T., Ohashi, K., Ogawa, H., Kanamori, H., Eto, T., Iwato, K., Sakamaki, H., Morishima, Y., Nagamura, T., Atsuta, Y. and Takami, A.
  • Journal Title: Biol Blood Marrow Transplant Volume: 20 Issue: 12 Pages: 2029-33
  • DOI: 10.1016/j.bbmt.2014.09.001
  • Peer Reviewed
• [Journal Article] Granulocyte colony-stimulating factor combined regimen in cord blood transplantation for acute myeloid leukemia: a nationwide retrospective analysis in Japan. (2014)
  • Author(s): 1.Konuma T, Ooi J, Uchida N, Ogawa H, Ohashi K, Kanamori H, Aotsuka N, Onishi Y, Yamaguchi H, Kozai Y, Nagamura-Inoue T, Kato K, Suzuki R, Atsuta Y, Kato S, Asano S, Takahashi S.
  • Journal Title: Haematologica Volume: 99(12) Issue: 12 Pages: e264-e268
  • DOI: 10.3324/haematol.2014.114504
  • Peer Reviewed / Open Access
• [Journal Article] The preventative effects of recombinant thrombomodulin on transplantation- associated coagulopathy after allogeneic hematopoietic stem cell transplantation (2014)
  • Author(s): Nomura S, Ishii K, Maeda Y, Katayama Y, Yagi H, Fujishima N, Ota S, Seki M, Okada M, Ikezoe T, Hayashi K, Fujita S, Satake A, Ito T, Kyo T, Ishida Y, Chiba S, Ogawa H, Tanimoto M, Sawada K
  • Journal Title: Journal of Stem Cell Research & Therapy Volume: 4 Issue: 1 Pages: 247-247
  • DOI: 10.1007/s12185-014-1696-6
  • Peer Reviewed / Open Access
• [Journal Article] Impact of HLA allele mismatch on the clinical outcome in serologically matched related hematopoietic SCT. (2014)
  • Author(s): Fuji S, Kanda J, Kato S, Ikegame K, Morishima S, Miyamoto T, Hidaka M, Kubo K, Miyamura K, Ohashi K, Kobayashi H, Maesako Y, Adachi S, Ichinohe T, Atsuta Y, Kanda Y; HLA Working Group of Japan Society for Hematopoietic Cell Transplantation.
  • Journal Title: Bone Marrow Transplant Volume: 49 Issue: 9 Pages: 1187-1192
  • DOI: 10.1038/bmt.2014.141
  • Peer Reviewed
• [Journal Article] Frequency of CD4(+)FOXP3(+) regulatory T-cells at early stages after HLA-mismatched allogeneic hematopoietic SCT predicts the incidence of acute GVHD. (2013)
  • Author(s): Fujioka T, Tamaki H, Ikegame K, Yoshihara S, Taniguchi K, Kaida K, Kato R, Inoue T, Nakata J, Ishii S, Soma T, Okada M, Ogawa H
  • Journal Title: Bone Marrow Transplant Volume: 48 Issue: 6 Pages: 859-864
  • DOI: 10.1038/bmt.2012.232
  • Peer Reviewed
• [Journal Article] Gender differences in health-related quality of life, physical function and psychological status among patients in the early phase following allogeneic haematopoietic stem cell transplantation. (2013)
  • Author(s): Morishita S, Kaida K, Yamauchi S, Wakasugi T, Yoshihara S, Taniguchi K, Ishii S, Ikegame K, Kodama N, Ogawa H, Domen K.
  • Journal Title: Psychooncology Volume: 22 Issue: 5 Pages: 1159-1166
  • DOI: 10.1002/pon.3128
  • Peer Reviewed
• [Journal Article] Irreversible neurological defects in the lower extremities after haploidentical stem cell transplantation: possible association with nelarabine. (2013)
  • Author(s): Kawakami M, Taniguchi K, Yoshihara S, Ishii S, Kaida K, Ikegame K, Okada M, Watanabe S, Nishina T, Hamada H, Nakagawa M, Ogawa H.
  • Journal Title: American Journal of Hematology Volume: 88 Issue: 10 Pages: 853-857
  • DOI: 10.1002/ajh.23502
  • Peer Reviewed
• [Journal Article] Detection of donor-derived CMV-spectific T cells in cerebrospinal fluid in a case of CMV meningoencephalitis after cord blood stem cell transplantation. (2013)
  • Author(s): Ikegame K, Kato R, Fujioka T, Okada M, Kaida K, Ishii S, Yoshihara S, Inoue T, Taniguchi K, Tamaki H, Soma T, Ogawa H.
  • Journal Title: Int J Hematol Volume: 97 Issue: 2 Pages: 289-290
  • DOI: 10.1007/s12185-012-1231-6
  • Peer Reviewed
• [Journal Article] Extramedullary relapse of acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation:an easily overlooked but significant pattern of relapse. (2012)
  • Author(s): Yohihara S, Ando T, Ogawa H.
  • Journal Title: Biol Blood Marrow Volume: 18 Issue: 12 Pages: 1800-1807
  • DOI: 10.1016/j.bbmt.2012.05.010
  • Peer Reviewed
• [Journal Article] Intrabone marrow transplantation of unwashed cord blood using reduced-intensity conditioning treatment : a phase I study (2012)
  • Author(s): Okada M, et al
  • Journal Title: Biology of blood and Marrow Transplantation Volume: 18 Issue: 4 Pages: 633-639
  • DOI: 10.1016/j.bbmt.2011.08.010
  • Peer Reviewed
• [Journal Article] Human umbilical cord provides a significant source of unexpanded mesenchymal stromal cells (2012)
  • Author(s): Kikuchi-Taura A, Taguchi A, Ogawa H, et al.(13人中12人)
  • Journal Title: Cytotherapy Volume: 14 Issue: 4 Pages: 441-450
  • DOI: 10.3109/14653249.2012.658911
  • Peer Reviewed
• [Presentation] 進行期血液腫瘍に対する、低用量ATGとステロイドを用いたUnmanipulated haploidentical RIST (2015)
  • Author(s): 小川啓恭
  • Organizer: 第37回日本造血細胞移植学会総会
  • Place of Presentation: 神戸ポートピアホテル 神戸
  • Year and Date: 2015-03-06
  • Invited
• [Presentation] 複数臍帯血/骨髄内臍帯血移植 (2015)
  • Author(s): 岡田昌也
  • Organizer: 第37回日本造血細胞移植学会総会
  • Place of Presentation: 神戸国際会議場 神戸
  • Year and Date: 2015-03-06
  • Invited
• [Presentation] 胎児付属物由来MSCを使いたGVHD治療法の開発 (2015)
  • Author(s): 相馬俊裕 山原研一 田口明彦 池上武史 黒田将子 藤盛好啓 田浦明映 柴原浩章 田中宏幸 小川啓恭
  • Organizer: 第37回日本造血細胞移植学会総会
  • Place of Presentation: 神戸国際会議場 神戸
  • Year and Date: 2015-03-06
• [Presentation] 樹状細胞の成熟はホスト由来制御性T細胞により抑制される:GVHD発症における重要な役割について (2015)
  • Author(s): 井上貴之 池亀和博 海田勝仁 岡田昌也 玉置広哉 相馬俊裕 小川啓恭
  • Organizer: 第37回日本造血細胞移植学会総会
  • Place of Presentation: 神戸国際会議場 神戸
  • Year and Date: 2015-03-06
• [Presentation] ハプロタイプを共用しない血縁ドナーからの造血幹細胞移植 (2015)
  • Author(s): 海田勝仁 池亀和博 井上貴之 岡田昌也 玉置広哉 相馬俊裕 小川啓恭
  • Organizer: 第37回日本造血細胞移植学会総会
  • Place of Presentation: 神戸国際会議場 神戸
  • Year and Date: 2015-03-06
• [Presentation] 同種造血幹細胞移植の適応とドナーの選択：成人 (2015)
  • Author(s): 池亀和博
  • Organizer: 第37回日本造血細胞移植学会総会
  • Place of Presentation: 神戸国際会議場 神戸
  • Year and Date: 2015-03-05
• [Presentation] Based on haplo, beyond haplo (2015)
  • Author(s): 池亀和博
  • Organizer: 第37回日本造血細胞移植学会総会
  • Place of Presentation: 神戸ポートピアホテル 神戸
  • Year and Date: 2015-03-05
  • Invited
• [Presentation] Spousal hematopoietic stem cell transplantation for post-transplant relapse/rejection. (2015)
  • Author(s): Ikegame K, Kaida K, Ishii S, Yoshihara S, Taniguchi K, Inoue T, Tamaki H, Okada M, Soma T, Ogawa H
  • Organizer: 2015 BMT Tandem Tandem Meetings
  • Place of Presentation: SanDiego, USA
  • Year and Date: 2015-02-11 – 2015-02-15
• [Presentation] The impact of HLA mismatch only in the host-versus-graft direction on the outcome of related hematopoietic stem cell transplantation for patients with HLA-homozygous Haplotypes: A Retrospective Analysis of the JSHCT HLA working group study (2015)
  • Author(s): Kanda J, Ikegame K, Fuji S, Fukuda T, Kurokawa M, Ogawa H, Ohashi K, Ishikawa J, Inoue M, Ichinohe T, Atsuta Y, Kanda Y
  • Organizer: 2015 BMT Tandem Tandem Meetings
  • Place of Presentation: San diego, USA
  • Year and Date: 2015-02-11 – 2015-02-15
• [Presentation] Low incidence of human herpesvirus 6 reactivation in unmanipulated HLA-haploidentical related stem cell transplantation with corticosteroid as graft-versus-host disesase prophylaxis (2015)
  • Author(s): Tamaki H, Ikegame K, Yoshihara S, Kaida K, Inoue T, Okada M, Soma T, Ogawa H
  • Organizer: 2015 BMT Tandem Tandem Meetings
  • Place of Presentation: San diego, USA
  • Year and Date: 2015-02-11 – 2015-02-15
• [Presentation] Soluble Interleukin-2 receptor level on day 7 as a predictor of GVHD after HLA-Haploidentical RIST (2014)
  • Author(s): Kaida K, Ikegame K, Ikemoto J, Murata R, Irie R, Yoshihara S, Ishii S, Okada M, Inoue T, Tamaki H, Soma T, Fujimori Y, Kai S, Ogawa H
  • Organizer: 第76回日本血液学会学術集会
  • Place of Presentation: 大阪国際会議場 大阪
  • Year and Date: 2014-11-02
• [Presentation] Analysis for HBV reactivation in CML treated with TKIs (2014)
  • Author(s): Okada M, Fujimori Y, Ifuku H, Takatsuka H, Asada T, Ooe Y, Toda A, Okamoto T, Shimizu Y, Mori A, Misawa M, Inoue T, Tokugawa T, Kaida K, Sawada A, Ikegame K, Tamaki H, Higasa S, Soma T, Ogawa H
  • Organizer: 第76回日本血液学会学術集会
  • Place of Presentation: 大阪国際会議場 大阪
  • Year and Date: 2014-11-02
• [Presentation] Haploidentical transplantation and further (2014)
  • Author(s): Ikegame K
  • Organizer: 2nd International Conference on Hematology & Blood Disorders
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2014-09-29 – 2014-10-01
  • Invited
• [Presentation] Clinical usefulness of WT1 mRNA expression in bone marrow detected using a new WT1 mRNA assay kit for monitoring acute myeloid leukemia: A comparison with peripheral blood WT1 mRNA expressions (2014)
  • Author(s): Ishiyama K, Miyawaki S, Kitamura K, Suzuki K, Ishikawa J, Ogawa H, Imai K, Naoe T, Chiba S, Miyazaki Y, Hatta Y, Kurokawa M, Ueda Y, Koga D, Sugiyama H, Takaku F
  • Organizer: The 19 th European Hematology Association
  • Place of Presentation: Milan, Italy
  • Year and Date: 2014-06-12 – 2014-06-15
• [Presentation] 顆粒球採取ドナーの採取に伴う副作用と採取後健康調査 (2014)
  • Author(s): 池本純子、藤盛好啓、小野本仁美、入江玲子、藤田典子、齋田和子、川口眞理子、井上貴之、海田勝仁、岡本恭明、池亀和博、玉置広哉、岡田昌也、大塚欣敏、谷澤隆邦、相馬俊裕、小川啓恭、甲斐俊朗
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄コンベンションセンター（沖縄）
• [Presentation] 血液がん―最新のトピックス (2013)
  • Author(s): 小川啓恭
  • Organizer: 第27回日本臨床内科医学会
  • Place of Presentation: 神戸国際会議場（神戸）
  • Invited
• [Presentation] Transition of conditioning regimen in haplo-mini in connection with survival results. (2013)
  • Author(s): Ikegame K, Kaida K, Ishii S, Yoshihara S, Taniguchi K, Kato R, Inoue T, Okada M, Tamaki H, Soma T, Ogawa H.
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: ロイトン札幌・さっぽろ芸文館 札幌市教育文化会館（札幌）
• [Presentation] Recombinant thrombomodulin suppresses FK506-induced endothelial death by prevebtubg Akt inactivation. (2013)
  • Author(s): Eguchi R, Fujimori Y, Okada M, Wakabayashi I, Ogawa H.
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: ロイトン札幌・さっぽろ芸文館 札幌市教育文化会館（札幌)
• [Presentation] Clinical outcomes of allogeneic hematopoietic stem cell transplantation with intravenous busulfan-based reduced-intensity conditioning for acute myeloid leukemia: A nationwide retrospective study from the adult AML working group of JSHCT. (2013)
  • Author(s): Yamashita T, Taniguchi S, Fukuda T, Ogawa H, Morishima Y, Nagamura T, Sakamaki H, Atsuta Y, Takami A
  • Organizer: The 39th EBMT annual meeting in 2013.
  • Place of Presentation: London, UK
• [Presentation] 血縁HLA半合致ミニ移植（haplo-mini)の多施設前向き臨床試験（第I/II相試験） (2013)
  • Author(s): 池亀和博、海田勝仁、石井慎一、吉原哲、谷口享子、加藤るり、井上貴之、岡田昌也、相馬俊裕、小川啓恭
  • Organizer: 第35回日本造血細胞移植学会総会
  • Place of Presentation: 石川県立音楽堂、他（金沢）
• [Presentation] FDG-PEt/CT early after 90Y-ibritumomab tiuxetan therapy predicts outcome in relapsed or refractory indolent B-cell lymphoma. (2012)
  • Author(s): Okada M, Fujimori Y, Oku N, Tamekane A, Nakajima T, Tokugawa T, Sawada A, Ishii S, Kaida K, Ikegame K, Soma T, Ogawa H.
  • Organizer: The 54th Annual Meeting and Exposition American Society of Hematology 2012
  • Place of Presentation: Geogia World Congress Center(Atlanta,USA)
• [Presentation] A novel regimen of unmanipulated HLA-haploidentical transplantation using a small dose of anti-T-lymphocyte globulin for patients in high tumor burden. (2012)
  • Author(s): Ishii S, Ikegame K, Kaida K, Yoshihara S, Okada M, Kato R, Inoue T, Tamaki H, Fujimori Y, Soma T, Ogawa H.
  • Organizer: The 54th Annual Meeting and Exposition American Society of Hematology 2012
  • Place of Presentation: Geogia World Congress Center(Atlanta,USA)
• [Presentation] HLA不適合移植におけるATGの役割（コーポレートセミナー） (2012)
  • Author(s): 小川啓恭
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Invited
• [Presentation] HLA-haploidentical myeloablative stem cell transplantation using anti-T-lymphocyte globulin. (2012)
  • Author(s): Ishii S, Ikegame K, Kaida K, Kato R, Inoue T, Yoshihara S, Okada M, Soma T, Ogawa H.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 国立京都国際会館（京都）
• [Book] 造血幹細胞 骨髄内臍帯血ミニ移植の臨床開発. Annual Review血液2013 (2013)
  • Author(s): 岡田昌也，小川啓恭
  • Total Pages: 248
  • Publisher: 中外医学社
• [Remarks] 兵庫医科大学 血液内科 研究内容
  • URL: http://www.hyo-med.ac.jp/department/hmt/kenkyuu.html