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Analysis of the genetic background of Sjogren's syndrome

Research Project

Project/Area Number 24591436
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionHokkaido University

Principal Investigator

Horita Tetsuya  北海道大学, 大学病院, 講師 (50399929)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsシェーグレン症候群 / 疾患感受性遺伝子 / 遺伝子多型 / 一塩基多型 / 膠原病 / 自己免疫疾患
Outline of Final Research Achievements

Genomic DNA samples from 190 primary Sjogren's syndrome (SS) patients and ethnically matched 428 healthy controls were collected. Several lupus susceptible genes were evaluated using TaqMan Genotyping Assay. The allele frequencies of lupus risk in SS were significantly higher in BLK (odds ratio (OR) =1.61, 95% confidence interval (CI):1.21-2.15), STAT4 (OR=1.83, 95%CI:1.43-2.36), IRF5 (OR=1.40, 95%CI:1.07-1.82) and rs10798269 in 1q25.1 region (OR=1.62, 95%CI:1.20-2.18), compared with those in healthy controls. No significant associations were found in BANK1, TNFSF13, TNFAIP3 and TNFSF4. BLK, STAT4, IRF5 and 1q25.1 region were not only lupus susceptible genes but SS susceptible genes in Japanese population. SS share, in part, common genetic background with SLE.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (35 results)

All 2015 2014 2013 2012

All Journal Article (30 results) (of which Peer Reviewed: 30 results,  Acknowledgement Compliant: 1 results,  Open Access: 14 results) Presentation (5 results)

  • [Journal Article] The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis.2015

    • Author(s)
      Kurita T, Yasuda S, Oba K, Odani T, Kono M, Otomo K, Fujieda Y, Oku K, Bohgaki T, Amengual O, Horita T, Atsumi T.
    • Journal Title

      Rheumatology (Oxford).

      Volume: 54 Issue: 8 Pages: 1536-1536

    • DOI

      10.1093/rheumatology/kev192

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Takayasu arteritis and ulcerative colitis -high concurrence ratio and genetic overlap.2015

    • Author(s)
      Terao C, Matsumura T, Yoshifuji H, Kirino Y, Maejima Y, Kochi Y, Ogimoto A, Yamamoto M, Takahashi H, Nakayamada S, Saito K, Wada Y, Narita I, Kawaguchi Y, Yamanaka H, Ohmura K, Atsumi T, Tanemoto K, Miyata T, Kuwana M, Komuro I, Tabara Y, Ueda A, Isobe M, Mimori T, Matsuda F.
    • Journal Title

      Arthritis Rheumatol.

      Volume: - Issue: 8 Pages: 2226-2232

    • DOI

      10.1002/art.39157

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comment on: The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis: reply.2015

    • Author(s)
      Yasuda S, Kurita T, Horita T, Atsumi T.
    • Journal Title

      Rheumatology (Oxford)

      Volume: 54 Issue: 6 Pages: 1129-1129

    • DOI

      10.1093/rheumatology/kev033

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β2-glycoprotein I/ HLA class II complexes are novel autoantigens in antiphospholipid syndrome.2015

    • Author(s)
      Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada H, Arase H.
    • Journal Title

      Blood

      Volume: 125 Issue: 18 Pages: 2835-2844

    • DOI

      10.1182/blood-2014-08-593624

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An independent validation of the global anti-phospholipid syndrome score in Japanese cohort of patients with antoimmune diseases2015

    • Author(s)
      Oku K, Amengual O, Bohgaki T, Horita T, Yasuda S, Atsumi T
    • Journal Title

      Lupus

      Volume: 24 Issue: 7 Pages: 774-775

    • DOI

      10.1177/0961203314561284

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comment on: The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis: reply.2015

    • Author(s)
      Yasuda S, Kurita T, Horita T, Atsumi T.
    • Journal Title

      Rheumatology (Oxford).

      Volume: -

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] β2-glycoprotein I / HLA class II complexes are novel autoantigens in antiphospholipid syndrome.2015

    • Author(s)
      Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada H, Arase H.
    • Journal Title

      Blood

      Volume: -

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An independent validation of the Global Anti-Phospholipid Syndrome Score in a Japanese cohort of patients with autoimmune diseases.2015

    • Author(s)
      Oku K, Amengual O, Bohgaki T, Horita T, Yasuda S, Atsumi T.
    • Journal Title

      Lupus

      Volume: -

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coronary and mesenteric involvement in polyarteritis nodosa.2015

    • Author(s)
      Watanabe K, Yasuda S, Noguchi A, Horita T, Atsumi T.
    • Journal Title

      Arthritis Rheumatol.

      Volume: 67 Issue: 2 Pages: 583-583

    • DOI

      10.1002/art.38954

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ras guanine nucleotide-releasing protein 4 is aberrantly expressed in the fibroblast-like synoviocytes of patients with rheumatoid arthritis and controls their proliferation.2015

    • Author(s)
      Kono M, Yasuda S, Stevens RL, Koide H, Kurita T, Shimizu Y, Kanetsuka Y, Oku K, Bohgaki T, Amengual O, Horita T, Shimizu T, Majima T, Koike T, Atsumi T.
    • Journal Title

      Arthritis Rheumatol

      Volume: 67 Issue: 2 Pages: 396-407

    • DOI

      10.1002/art.38924

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis.2015

    • Author(s)
      Kurita T, Yasuda S, Oba K, Odani T, Kono M, Otomo K, Fujieda Y, Oku K, Bohgaki T, Amengual O, Horita T, Atsumi T.
    • Journal Title

      Rheumatology (Oxford)

      Volume: 54 Issue: 1 Pages: 39-44

    • DOI

      10.1093/rheumatology/keu166

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased expression of Runx1 and lowered proportion of Foxp3+CD25+CD4+ regulatory T cells in systemic sclerosis.2015

    • Author(s)
      Kataoka H, Yasuda S, Fukaya S, Oku K, Horita T, Atsumi T, Koike T
    • Journal Title

      Mod Rheumatol.

      Volume: 25 Issue: 1 Pages: 90-95

    • DOI

      10.3109/14397595.2014.899736

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term outcome in Japanese patients with lupus nephritis.2014

    • Author(s)
      Kono M, Yasuda S, Kato M, Kanetsuka Y, Kurita T, Fujieda Y, Otomo K, Horita T, Oba K, Kondo M, Mukai M, Yanai M, Fukasawa Y, Atsumi T
    • Journal Title

      Lupus

      Volume: 23 Issue: 11 Pages: 1124-1132

    • DOI

      10.1177/0961203314536246

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility2014

    • Author(s)
      Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H
    • Journal Title

      Proceedings of National Academy of Science USA

      Volume: 111 Issue: 10 Pages: 3787-3792

    • DOI

      10.1073/pnas.1401105111

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiprothrombin antibodies.2014

    • Author(s)
      Amengual O, Horita T, Binder W, Norman GL, Shums Z, Kato M, Otomo K, Fujieda Y, Oku K, Bohgaki T, Yasuda S, Atsumi T
    • Journal Title

      Rheumatol Int.

      Volume: 34 Issue: 9 Pages: 1225-1230

    • DOI

      10.1007/s00296-014-2951-0

    • NAID

      120005656328

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modifying effect of N-acetyltransferase 2 genotype on the association between systemic lupus erythematosus and consumption of alcohol and caffeine-rich beverages.2014

    • Author(s)
      Kiyohara C1, Washio M, Horiuchi T, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, Tada Y; Kyushu Sapporo SLE (KYSS) Study Group.
    • Journal Title

      Arthritis Care Res (Hoboken)

      Volume: 66 Issue: 7 Pages: 1048-1056

    • DOI

      10.1002/acr.22282

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical significance of antiphospholipid antibody measured by EliA anticardiolipin antibodies and anti-β2Glycoprotein I antibodies in antiphospholipid syndrome2014

    • Author(s)
      Fujieda Y, Shida H, Oku K, Bohgaki T, Amengual O, Horita T, Yasuda S, Atsumi T.
    • Journal Title

      Japanese Journal of Clinical Immunology

      Volume: 37 Issue: 5 Pages: 430-436

    • DOI

      10.2177/jsci.37.430

    • NAID

      130004875940

    • ISSN
      0911-4300, 1349-7413
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Psychological stress in a Japanese population with systemic lupus erythematosus: finding from KYSS study.2014

    • Author(s)
      Takahashi H, Washio M, Kiyohara C, Tada Y, Asami T, Ide S, Atsumi T, Kobashi G, Yamamoto M, Horiuchi T; Kyushu Sapporo Sle (Kyss) Study Group.
    • Journal Title

      Mod Rheumatol.

      Volume: 24 Issue: 3 Pages: 448-452

    • DOI

      10.3109/14397595.2013.843745

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility.2014

    • Author(s)
      Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 111 Pages: 3787-3792

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiprothrombin antibodies.2014

    • Author(s)
      Amengual O, Horita T, Binder W, Norman GL, Shums Z, Kato M, Otomo K, Fujieda Y, Oku K, Bohgaki T, Yasuda S, Atsumi T.
    • Journal Title

      Rheumatol Int

      Volume: -

    • NAID

      120005656328

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis.2014

    • Author(s)
      Kurita T, Yasuda S, Oba K, Odani T, Kono M, Otomo K, Fujieda Y, Oku K, Bohgaki T, Amengual O, Horita T, Atsumi T.
    • Journal Title

      Rheumatology (Oxford).

      Volume: -

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decreased expression of Runx1 and lowered proportion of Foxp3+ CD25+ CD4+ regulatory T cells in systemic sclerosis.2014

    • Author(s)
      Kataoka H, Yasuda S, Fukaya S, Oku K, Horita T, Atsumi T, Koike T.
    • Journal Title

      Mod Rheumatol

      Volume: -

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Essential role of the p38 mitogen-activated protein kinase pathway in tissue factor gene expression mediated by the phosphatidylserine-dependent antiprothrombin antibody.2013

    • Author(s)
      Oku K, Amengual O, Zigon P, Horita T, Yasuda S, Atsumi T.
    • Journal Title

      Rheumatology (Oxford).

      Volume: 52 Issue: 10 Pages: 1775-1784

    • DOI

      10.1093/rheumatology/ket234

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The involvement of CD36 in monocyte activation by antiphospholipid antibodies.2013

    • Author(s)
      Kato M, Atsumi T, Oku K, Amengual O, Nakagawa H, Fujieda Y, Otomo K, Horita T, Yasuda S, Koike T.
    • Journal Title

      Lupus

      Volume: 22 Issue: 8 Pages: 761-771

    • DOI

      10.1177/0961203313490242

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes.2013

    • Author(s)
      Shimane K, Kochi Y, Suzuki A, Okada Y, Ishii T, Horita T, Saito K, Okamoto A, Nishimoto N, Myouzen K, Kubo M, Hirakata M, Sumida T, Takasaki Y, Yamada R, Nakamura Y, Kamatani N, Yamamoto K.
    • Journal Title

      Rheumatology (Oxford)

      Volume: 52 Issue: 7 Pages: 1172-82

    • DOI

      10.1093/rheumatology/kes427

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid2012

    • Author(s)
      Fujieda Y, Atsumi T, Amengual O, Odani T, Otomo K, Kato M, Oku K, Kon Y, Horita T, Yasuda S, Koike T
    • Journal Title

      syndromeLupus

      Volume: 21(14) Issue: 14 Pages: 1506-14

    • DOI

      10.1177/0961203312458469

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Up-regulated expression of HLA-DRB5 transcripts and high frequency of the HLA-DRB5*01:05 allele in scleroderma patients with interstitial lung disease.2012

    • Author(s)
      Odani T, Yasuda S, Ota Y, Fujieda Y, Kon Y, Horita T, Kawaguchi Y, Atsumi T, Yamanaka H, Koike T.
    • Journal Title

      Rheumatology (Oxford)

      Volume: 51 Pages: 1765-1774

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phospholipid scramblase 1 expression is enhanced in patients with antiphospholipid syndrome2012

    • Author(s)
      Amengual O, Atsumi T, Oku K, Suzuki E, Horita T, Yasuda S, Koike T
    • Journal Title

      Mod Rheumatol

      Volume: 23(1) Issue: 1 Pages: 81-8

    • DOI

      10.1007/s10165-012-0642-9

    • NAID

      10031167669

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese2012

    • Author(s)
      岡田随象
    • Journal Title

      PLoS Genetics

      Volume: (掲載確定) Issue: 1 Pages: 1002455-1002455

    • DOI

      10.1371/journal.pgen.1002455

    • NAID

      120005906866

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The efficacy of antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events2012

    • Author(s)
      Otomo K, Atsumi T, Amengual O, Fujieda Y, Kato M, Oku K, Horita T, Yasuda S, Koike T
    • Journal Title

      Arthritis Rheum

      Volume: 64 Issue: 2 Pages: 504-512

    • DOI

      10.1002/art.33340

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Haematopoietic stem cell transplantation for interstitial lung diseases in patients with systemic sclerosis; Therapeutic effect and evaluation of up-regulated genes.2012

    • Author(s)
      Yasuda S, Odani T, Ota Y, Fujieda Y, Kon Y, Horita T, Kawaguchi Y, Atsumi T, Yamanaka H, Koike T.
    • Organizer
      The 8th international congress on autoimmunity
    • Place of Presentation
      Palacio de Exposiciones y Congresos de Granada (Spain)
    • Related Report
      2012 Research-status Report
  • [Presentation] The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis2012

    • Author(s)
      T. Kurita, S. Yasuda, K. Oba, K. Otomo, H. Shida, T. Watanabe, Y. Kanetsuka, M. Kono, T. Odani, Y. Fujieda, Y. Kon, T. Horita, N. Sato, T. Atsumi
    • Organizer
      EULAR Annual European Congress of Rheumatology
    • Place of Presentation
      Messe Berlin (Germany)
    • Related Report
      2012 Research-status Report
  • [Presentation] Central nervous system involvements in systemic vasculitis.2012

    • Author(s)
      Kanetsuka T, Horita T, Watanabe T, Kono M, Kurita T, Fujieda Y, Odani T, Oku K, Bohgaki T, Yasuda S, Atsumi T.
    • Organizer
      The 15th Congress of the Asia Pacific League of Associations for Rheumatology
    • Place of Presentation
      the King Hussein Bin Talal Convention Center (Jordan)
    • Related Report
      2012 Research-status Report
  • [Presentation] Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocyte2012

    • Author(s)
      Fujieda Y, Amengual O, Kanetsuka Y, Odani T, Otomo K, Oku K, Bohgaki T, Horita T, Yasuda S, Kuroki K, Maenaka K, Matsumoto M, Hatakeyama S, Atsumi T
    • Organizer
      Annual Meeting of American College of Rheumatology
    • Place of Presentation
      Walter E. Washington Convention Center (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Dual antiplatelet therapy as prophylaxis of recurrent arterial thrombosis in patients with antiphospholipid syndrome2012

    • Author(s)
      Fujieda Y, Amengual O, Watanabe T, Kono M, Kanetsuka Y, Kurita T, Odani T, Otomo K, Oku K, Bohgaki T, Horita T, Yasuda S, Atsumi T
    • Organizer
      Annual Meeting of American College of Rheumatology
    • Place of Presentation
      Walter E. Washington Convention Center (USA)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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