Development of new therapeutic modalities for Rheumatoid Arthritis
| Project/Area Number |
24591442
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | Juntendo University (2013-2014)
The University of Tokyo (2012) |
|---|
Principal Investigator |
IWATA SATOSHI 順天堂大学, 医学(系)研究科(研究院), 講師 (00396871)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MORIMOTO Chikao 順天堂大学, 大学院医学研究科, 教授 (30119028)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 関節リウマチ / コラーゲン誘導関節炎 / 接着分子 / インテグリン / ドッキング蛋白質 / Cas-L / Nedd9 / マクロライド / シグナル伝達 / アダプター蛋白質 / マグロライド / アダプタータンパク質 |
|---|
| Outline of Final Research Achievements |
Cas-L is a cytoplasmic docking protein essential for cellular migration and beta 1 integrin-mediated costimulation of T cells. Our current study expanded these findings on the role of Cas-L in the development of rheumatoid arthritis (RA) by analyzing the pathophysiological changes in a Cas-L -/- mouse collagen-induced arthritis (CIA) model, strongly suggesting that Cas-L plays a pivotal role in the pathophysiology of CIA, and that Cas-L may be a potential molecular target for the treatment of RA.
Macrolide antibiotics have immunomodulatory properties that are distinct from their anti-bacterial functions. We synthesized 5-I, which is a new derivative of roxithromycin with less antimicrobial activity, and evaluated its immunomodulatory effects. Administration of 5-I to mice with CIA reduced the severity of arthritis, and this effect was also observed when treatment was delayed till after the onset of disease, suggesting that 5-I may be useful as a potential therapeutic agent for RA.
|
Report
(4 results)
Research Products
(15 results)
-
-
-
-
-
-
[Journal Article] Regulation of somatostatin receptor 4-mediated cytostatic effects by CD26 in malignant pleural mesothelioma.2014
Author(s)
Yamamoto J, Ohnuma K, Hatano R, Okamoto T, Komiya E, Yamazaki H, Iwata S, Dang NH, Aoe K, Kishimoto T, Yamada T, Morimoto C.
-
Journal Title
Br J Cancer.
Volume: Vol 110
Issue: 9
Pages: 2232-45
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
