Investigation for the pathogenesis of IgG4-related disease
| Project/Area Number |
24591447
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Okayama University |
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Principal Investigator |
SATO Yasuharu 岡山大学, 保健学研究科, 准教授 (00579831)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | IgG4-related disease / Pathogenesis / Mast cell / IgE |
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| Outline of Final Research Achievements |
IgG4-related disease is a systemic disorder with unique clinicopathologic features and uncertain etiological features and is frequently related to allergic disease. T helper 2 (Th2) and regulatory T cell (Treg) cytokines have been reported to be upregulated in the affected tissues; thus, the production of these cytokines by Th2 and Treg cells has been suggested as an important factor in the pathogenesis of IgG4-related disease. However, it is not yet clear which cells produce these cytokines in IgG4-related disease, and some aspects of the disorder cannot be completely explained by T cell-related processes. We found that the mast cells were strongly positive for these cytokines in IgG4-related disease. Our results indicate that mast cells produce Th2 and Treg cytokines in tissues affected by IgG4-related disease and possibly play an important role in disease pathogenesis.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] IgG4-related renal disease: clinical and pathological characteristics.2014
Author(s)
Kuroda N, Nao T, Fukuhara H, Karashima T, Inoue K, Taniguchi Y, Takeuchi Y, Zen Y, Sato Y, Notohara K, Yoshino T.
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Journal Title
Int J Clin Exp Pathol.
Volume: 7
Pages: 6379-6385
Related Report
Peer Reviewed
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[Journal Article] T helper 2 and regulatory T cell cytokine production by mast cells: A key factor in the pathogenesis of IgG4-related disease.2014
Author(s)
Takeuchi, M., Sato, Y., Ohno, K., Tanaka, S., Takata, K., Gion, Y., Orita,Y., Ito, T., Tachibana, T. and Yoshino, T.
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Journal Title
Mod. Pathol.
Volume: 27
Issue: 8
Pages: 1126-1136
DOI
Related Report
Peer Reviewed
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[Journal Article] Epstein-Barr Virus-infected Cells in IgG4-related Lymphadenopathy With Comparison With Extranodal IgG4-related Disease.2014
Author(s)
Takeuchi M, Sato Y, Yasui H, Ozawa H, Ohno K, Takata K, Gion Y, Orita Y, Tachibana T, Itoh T, Asano N, Nakamura S, Swerdlow SH, Yoshino T.
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Journal Title
Am J Surg Pathol.
Volume: －
Issue: 7
Pages: 946-955
DOI
Related Report
Peer Reviewed
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[Journal Article] A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration.2014
Author(s)
Hara S, Kawano M, Mizushima I, Yamada K, Fujita K, Harada K, Matsumura M, Yamagishi M, Sato Y, Yamaguchi Y, Nakanuma Y, Nagata M.
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Journal Title
Mod Rheumatol
Volume: 0
Issue: 5
Pages: 0-0
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Epstein-Barr virus-infected cells in IgG4-related lymphadenopathy with comparison to extranodal IgG4-related disease.2014
Author(s)
Takeuchi M, Sato Y, Yasui H, Ozawa H, Ohno K, Takata K, Gion Y, Orita Y, Tachibana T, Itoh T, Asano N, Nakamura S, Swerdlow SH, Yoshino T.
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Journal Title
American Journal of Surgical Pathology
Volume: in Press
Related Report
Peer Reviewed
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[Journal Article] Clinicopathologic analysis of IgG4-related skin disease.2013
Author(s)
Sato Y, Takeuchi M, Takata K, Ohno K, Iwaki N, Orita Y, Goto N, Hida AI, Iwamoto T, Asano N, Ito T, Hanakawa H, Yanai H, Yoshino T.
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Journal Title
Mod Pathol.
Volume: 26
Issue: 4
Pages: 523-532
DOI
Related Report
Peer Reviewed
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[Journal Article] Mucosa-associated lymphoid tissue lymphoma of the thyroid with abundant IgG4-positive plasma cells.2012
Author(s)
Miki K, Orita Y, Sato Y, Sugitani I, Noyama M, Fuji S, Domae S, Nose S, Hamaya K, Yoshino T, Nishizaki K.
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Journal Title
Auris Nasus Larynx
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Association between IgG4-related disease and progressively transformed germinal centers of lymph node.2012
Author(s)
Sato Y, Inoue D, Asano N, Takata K, Asaoku H, Maeda Y, Morito T, Okumura H, Ishizawa S, Matsui S, Miyazono T, Takeuchi T, Kuroda N, Orita Y, Takagawa K, Kojima M, Yoshino T.
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Journal Title
Modern Pathology
Volume: 25
Pages: 956-967
Related Report
Peer Reviewed
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[Presentation] Multicentric Castleman's disease2014
Author(s)
Yasuharu Sato, Tadashi Yoshino
Organizer
The 2nd International Symposium on IgG4-Related Disease & Associated Conditions
Place of Presentation
Sheraton Waikiki Hotel, Hawaii, USA.
Related Report
Invited
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