| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Outline of Final Research Achievements |
IgG4-related disease is a systemic disorder with unique clinicopathologic features and uncertain etiological features and is frequently related to allergic disease. T helper 2 (Th2) and regulatory T cell (Treg) cytokines have been reported to be upregulated in the affected tissues; thus, the production of these cytokines by Th2 and Treg cells has been suggested as an important factor in the pathogenesis of IgG4-related disease. However, it is not yet clear which cells produce these cytokines in IgG4-related disease, and some aspects of the disorder cannot be completely explained by T cell-related processes. We found that the mast cells were strongly positive for these cytokines in IgG4-related disease. Our results indicate that mast cells produce Th2 and Treg cytokines in tissues affected by IgG4-related disease and possibly play an important role in disease pathogenesis.
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