| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The number of circulating CD14+CD15-CXCR4high monocytes (Mos) possibly involved in joint repair in RA decreased in RA patients compared with that in healthy donors. Moreover, the expression of IL-6, TNF alpha, and CCR5 were high in CD14+CD15+CXCR4low Mos possibly involved in joint destruction in RA, and the expression of CX3CR1 was high in CD14+CD15-CXCR4high Mos, indicating that these cell groups may be controled by different factors. Furhtermore, the number of circulating CD14brightCD16- (classical) Mos decreased in RA patients compared with that in healthy donors, and classical Mos were decreased in RA patients with a response to methotrexate after treatment. These results indicate that classical Mos also may involve in the joint destruction.
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