Role of Th17 cells and related cytokines on the bone destruction by rheumatoid synovium
| Project/Area Number |
24591456
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Tokai University |
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Principal Investigator |
SUZUKI Yasuo 東海大学, 医学部, 教授 (90129495)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 関節リウマチ / 関節破壊 / 破骨細胞 / Th17細胞 / 包括的変動蛋白解析 / 炎症性骨破壊 / IL-17 family / 骨破壊 / Th-17細胞 |
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| Outline of Final Research Achievements |
To clarify the role of Th17 cells and IL-17 family in the bone destruction by the rheumatoid synovium, we analyzed the cytokines that are produced by Th17 cells and that regulating the differentiation, survive, and activation of Th17 cells by multiple analyte profiling in the culture of the synovial tissues derived from patients with rheumatoid arthritis (RA) and osteoarthritis (OA).
These results indicate that an excessive formation of osteoclast in the culture of rheumatoid synovium might be caused through the activation of RANKL/RANK system in connection with the induction of Th17 cells.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Exome sequencing identifies novel rheumatoid arthritis-susceptible variants in the BTNL2.2013
Author(s)
Mitsunaga S, Hosomichi K, Okudaira Y, Nakaoka H, Kunii N, Suzuki Y, Kuwana M, Sato S, Kaneko Y, Homma Y, Kashiwase K, Azuma F, Kulski JK, Inoue I, Inoko H.
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Journal Title
J Hum Genet.
Volume: 58
Issue: 4
Pages: 210-215
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Associations between six classical HLA loci and rheumatoid arthritis: a comprehensive analysis2012
Author(s)
S. Mitsunaga, Y. Suzuki, M. Kuwana, S. Sato, Y. Kaneko, Y. Homma, A. Narita, K. Kashiwase, Y. Okudaira, I. Inoue, J. K. Kulski and H. Inoko
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Journal Title
Tissue Antigens
Volume: Vol.80
Issue: 1
Pages: 16-25
DOI
Related Report
Peer Reviewed
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