| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
To clarify the role of Th17 cells and IL-17 family in the bone destruction by the rheumatoid synovium, we analyzed the cytokines that are produced by Th17 cells and that regulating the differentiation, survive, and activation of Th17 cells by multiple analyte profiling in the culture of the synovial tissues derived from patients with rheumatoid arthritis (RA) and osteoarthritis (OA).
These results indicate that an excessive formation of osteoclast in the culture of rheumatoid synovium might be caused through the activation of RANKL/RANK system in connection with the induction of Th17 cells.
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