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EBV induced erosive arthritis in humanized NOG mouse

Research Project

Project/Area Number 24591457
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionNihon University

Principal Investigator

TAKEI Masami  日本大学, 医学部, 教授 (30179600)

Co-Investigator(Kenkyū-buntansha) SHIRAIWA Hidetaka  日本大学, 医学部, 助教 (20451338)
Co-Investigator(Renkei-kenkyūsha) KITAMURA Noboru  日本大学, 医学部, 准教授 (40349999)
IWATA Mitsuhiko  日本大学, 医学部, 兼任講師 (50193751)
IKUMI Natsumi  日本大学, 医学部, 専修医 (50727857)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords関節リウマチ / EBウイルス / びらん性関節炎 / 破骨細胞 / NOGマウス / ヒト化マウス / Epstein-Barrウイルス(EBV) / ビラン性関節炎 / 骨改造 / ヒト免疫化マウス(NOG) / 生物学的製剤 / Epstein-Barrウイルス(EBV) / ヒト免疫化マウス / Epstein-Barrウイルス / ヒト免役化マウス / 治療実験
Outline of Final Research Achievements

NOG mice are injected with human CD34+ stem cells from cord blood (LONZA) intravenously. Erosive arthritis was observed histologically at the high rate of almost 100%. Human cathepsin K stain and TRAP of multinuclear cells that exist in bone erosion were positive. Multinucleated giant cells resemble osteoclasts are observed in cultured bone marrow cells with human RANKL and M-CSF. Human cathepsin K, mitochondria stain and TRAP were all positive in these multinucleated cells.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] ヒト化マウスを用いるウイルス感染症研究:病態の再現から予防・治療法の評価まで2015

    • Author(s)
      藤原成悦 今留謙一 武井正美
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63 Pages: 263-270

    • NAID

      40020393369

    • Related Report
      2014 Annual Research Report
  • [Journal Article] EBウイルスと関節リウマチ2015

    • Author(s)
      岩田光浩 長澤洋介 藤原成悦 武井正美
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63 Pages: 86-101

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 関節リウマチと帯状疱疹:頻度とリスクマネジメント2015

    • Author(s)
      北村 登, 武井正美
    • Journal Title

      リウマチ科

      Volume: 53 Pages: 210-215

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Tocilizumab Treatment Increases Left Ventricular Ejection Fraction and Decreases Left Ventricular Mass Index in Patients with Rheumatoid Arthritis without Cardiac Symptom2014

    • Author(s)
      Kobayashi H, Kobayashi Y, Giles JT, Yoneyama K, Nakajima Y, Takei M.
    • Journal Title

      J Rheumatol

      Volume: 41 Pages: 1916-1921

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 膠原病における免疫抑制の使い方―ミゾリビン2014

    • Author(s)
      北村 登,武井正美
    • Journal Title

      リウマチ科

      Volume: 51 Pages: 52-57

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 関節リウマチの原因としてのEpstein-Barrウイルス2014

    • Author(s)
      武井正美
    • Journal Title

      日大医学雑誌

      Volume: 73 Pages: 45-49

    • NAID

      130005070890

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Human Osteoclasts Are Mobilized in Erosive Arthritis of Epstein-Barr Virus-Infected Humanized NOD/Shi-Scid/IL-2Rγnull Mice.2014

    • Author(s)
      Y Nagasawa, N Ikumi, T Nozaki, H Inomata, K Imadome, N Kitamura, M Iwata, S Fujiwara, M Takei.
    • Organizer
      American College of Rheumatology Annual Meeting. ACR
    • Place of Presentation
      ボストン(USA)
    • Year and Date
      2014-11-14 – 2014-11-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] ウイルス再活性化(ヘルペス属を中心に)2014

    • Author(s)
      北村 登, 武井正美.
    • Organizer
      第58回日本リウマチ学会総会・学術集会
    • Place of Presentation
      高輪プリンスホテル(東京)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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