The role of RAGE for allergic airway responses
| Project/Area Number |
24591463
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANEHIRO Arihiko 岡山大学, 大学院医歯薬学総合研究科, 准教授 (20243503)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 気管支喘息 / RAGE / 終末糖化産物受容体 / 気道炎症 / 気道過敏性 / bronchial asthma / 特になし |
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| Outline of Final Research Achievements |
The receptor for advanced glycation end-products (RAGE) is a multi-ligand receptor which belongs to the immunoglobulin superfamily. RAGE is reported to be involved in various inflammatory disorders, however, studies that address the role of RAGE in allergic airway disease are inconclusive. RAGE sufficient (RAGE+/+) and RAGE deficient (RAGE-/-) mice were sensitized to ovalbumin (OVA), and airway responses were monitored after OVA challenge. RAGE-/- mice showed reduced eosinophilic inflammation and goblet cell metaplasia, lower T helper type 2 (Th2) cytokine production from spleen and peribronchial lymph node mononuclear cells, and lower numbers of group 2 innate lymphoid cells (ILC2s) in the lung compared to RAGE+/+ mice following sensitization and challenge. Thus, manipulating RAGE represents a novel therapeutic target in controlling allergic airway responses.
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Report
(4 results)
Research Products
(7 results)
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[Presentation] Allergen-induced airway inflammation requires the receptor for advanced glycation end products triggering on airway structural cells2014
Author(s)
A.Taniguchi, N.Miyahara, A.Kanehiro, K.Waseda, E.Kurimoto, U.Fujii, Y.Tanimoto, M.Kataoka, Y. Yamamoto, E.W. Gelfand , H. Yamamoto, M.Tanimoto.
Organizer
Annual meeting of American Thoracic Society 2014
Place of Presentation
Sandiego, CA, USA
Year and Date
2014-05-17 – 2014-05-24
Related Report
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[Presentation] Allergen-induced airway inflammation requires the receptor for advanced glycation end products triggering on airway structural cells2014
Author(s)
A.Taniguchi, N.Miyahara, A.Kanehiro, K.Waseda, E.Kurimoto, U.Fujii, Y.Tanimoto, M.Kataoka, Y. Yamamoto, E.W. Gelfand , H. Yamamoto, M.Tanimoto.
Organizer
Annual meeting of American Thoracic Society 2014
Place of Presentation
サンディエゴ、USA
Related Report
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[Presentation] Essential Role of the Receptor for Advanced Glycation End-Products to the Development of Allergic Airway Inflammation2013
Author(s)
A.Taniguchi, N.Miyahara, A.Kanehiro, K.Waseda, E.Kurimoto, Y.Tanimoto, M.Kataoka, Y. Yamamoto, H. Yamamoto, E.W. Gelfand , K. Kiura, M.Tanimoto.
Organizer
第53回日本呼吸器学会学術講演会
Place of Presentation
東京国際フォーラム
Related Report
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[Presentation] A.Taniguchi, N.Miyahara, A.Kanehiro, K.Waseda, E.Kurimoto, Y.Tanimoto, M.Kataoka, Y. Yamamoto, H. Yamamoto, E.W. Gelfand , K. Kiura, M.Tanimoto.2013
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