| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Dendritic cells (DCs) have functional plasticity, by which distinct immune responses are induced depending on the nature of infection and inflammation. This phenomenon is granted by the fact that DCs can be differentially activated by distinct activating agents. DC activation through Toll-like receptors results in IL-12 production together with expression of IRF8 and STAT4, critical components of the IL-12 genes transcription. I found that type I interferon (IFN-beta) can induce IRF8 and STAT4 via ERK activation, where Th2-promoting activity of DCs that can be induced by TSLP is irreversibly lost. Thus, the type I IFN is suggested as the major factor that controls DC functional plasticity.
|
