| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Autophagy is the essential function for controlling various biological responses including starvation, homeostatic turnover of long-lived proteins, and invasion of bacteria. However, a role for autophagy in the development and function of mast cells is largely unknown. We recently have reported that autophagy-related gene (Atg) 7, a critical enzyme for autophagosome formation, has relevance of mast cell functions using bone marrow-derived mast cells (BMMCs) from Atg7-deficient mice. To define further the roles for autophagy in mast cell function, we analyzed the changes of Atgs in mast cells after IgE-mediated activation using PCR-array. We found further that Atg9b, Gamma-aminobutyric acid A receptor-associated protein-like 1 (GABARAPL1), a homolog of Atg8, were also associated in the degranulation and regranulation of mast cells. Collectively, these results may lead to help modifing the mast cell function by targeting these proteins.
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