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Mechanisms of impaired function of CD4+CD25+FOXP3+ T cells in patients of asthma

Research Project

Project/Area Number 24591471
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionShowa University

Principal Investigator

NEGORO TAKAHARU  昭和大学, 薬学部, 講師 (70218270)

Co-Investigator(Kenkyū-buntansha) NAKANO Yasuko  昭和大学, 薬学部, 教授 (20155790)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords制御性T細胞 / カルシウム / RACK1 / 酸化ストレス / ペルオキシレドキシン / ERK / 国際情報交換 / イギリス:スペイン / アレルギー疾患 / カルシウムチャネル / カルシウムイオン / 免疫抑制 / CRACチャネル / イギリス:スペイン:アメリカ
Outline of Final Research Achievements

One of the asthma pathologies is a persistent inflammation in airway caused by allergens and viruses. The impaired functions and decreased number of regulatory T cells (Tregs) is considered as the cause of persistent inflammation in local sites. The mechanisms of abnormal functions of Tregs are obscure. Therefore, the aim of this study was to analyze the functions of Tregs by using Ca2+ response against T cell receptor stimulation, which can estimate the regulatory functions of Tregs, and to elucidate the mechanisms of abnormal functions of Tregs. The results showed that increasing Ca2+ response in Tregs from patients with asthma was attributed to the increasing expression of scaffold protein, RACK1. In addition, the new data associated with the abnormal functions of Tregs was obtained from microarray analysis.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (14 results)

All 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Elevated receptor for activated C kinase 1 expression is involved in intracellular Ca2+ influx and potentially associated with compromised regulatory T cell function in patients with asthma2014

    • Author(s)
      Negoro T, Shimizu S, Narushima M, Banham AH, Wakabayashi H, Takayanagi R, Hagiwara T, Roncador R, Osabe T, Yanai T, Kin T, Ikeda K, Endo A, Akiyama H, Nakano Y
    • Journal Title

      Clin Exp Allergy

      Volume: 44 Issue: 9 Pages: 1154-1169

    • DOI

      10.1111/cea.12375

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca(2+) entry2014

    • Author(s)
      Shimizu S, Yonezawa R, Hagiwara T, Yoshida T, Takahashi N, Hamano S, Negoro T, Toda T, Wakamori M, Mori Y, Ishii M
    • Journal Title

      Eur J Pharmacol

      Volume: 742 Pages: 22-30

    • DOI

      10.1016/j.ejphar.2014.08.023

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A simple smart amplification assay for the rapid detection of human cytomegalovirus in the urine of neonates2014

    • Author(s)
      Kohda C, Chiba N, Shimokoba K, Mizuno K, Negoro T, Nakano Y, Tanaka K
    • Journal Title

      J Virol Methods

      Volume: 208 Pages: 160-165

    • DOI

      10.1016/j.jviromet.2014.07.034

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potentiated macrophage activation by acid sensing under low adiponectin levels.2014

    • Author(s)
      Negoro T, Kin M, Takuma A, Saito K, Shimizu S, Nakano Y
    • Journal Title

      Mol Immunol

      Volume: 57 Issue: 2 Pages: 141-150

    • DOI

      10.1016/j.molimm.2013.08.015

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Metformin modulates GLP-1- and GIP-mediated intracellular signaling under normoglycemic conditions2013

    • Author(s)
      K Shinmura, T Negoro, S Shimizu, G Roncador, T Hirano, Y Nakano
    • Journal Title

      Open J Endocr and Metab Dis

      Volume: 3 Issue: 07 Pages: 263-270

    • DOI

      10.4236/ojemd.2013.37036

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury2013

    • Author(s)
      Hiroi T, Wajima T, Negoro T, Ishii M, Yasuko Nakano, Kiuchi K, Mori Y, and Shimizu S
    • Journal Title

      Cardiovasc Res

      Volume: vol.97 Issue: 2 Pages: 271-281

    • DOI

      10.1093/cvr/cvs332

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adiponectin enhances calcium-dependency of mouse bladder contraction mediated by protein kinase Cα expression.2013

    • Author(s)
      Nobe K, Fujii A, Saito K, Negoro T, Ogawa Y, Nakano Y, Hashimoto T, Honda K.
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 345 Issue: 1 Pages: 62-68

    • DOI

      10.1124/jpet.112.202028

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low HCMV DNA Copies Can Establish Infection and Result in Significant Symptoms in Extremely Preterm Infants: A Prospective Study.2012

    • Author(s)
      Wakabayashi H, Mizuno K, Kohda C, Negoro T, Maekawa C, Sawato S, Tanaka K, Nakano Y, Murayama J, Taki M, Miyazawa T, Murase M, Aizawa M, Nakano Y, Sakurai M, Takahashi K, Itabashi K.
    • Journal Title

      Am J Perinatol

      Volume: 29 Issue: 05 Pages: 377-382

    • DOI

      10.1055/s-0031-1300971

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Potentiated macrophage activation by acid sensing under low adiponectin levels2012

    • Author(s)
      T Negoro, H Akiyama, T Tanioka, K Saito, S Shimiz
    • Organizer
      The 64th Fujihara Seminar
    • Place of Presentation
      北海道苫小牧市
    • Related Report
      2012 Research-status Report
  • [Presentation] 関節リウマチにおけるアディポネクチンの生理的機能解明2012

    • Author(s)
      秋山晴代,嶋田紘也,齊藤清美,根来孝治,中野泰子
    • Organizer
      第35回 日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Research-status Report
  • [Book] Bronchial asthma-Emerging therapeutic strategies Chapter 4; Immunomechanisms of childhood asthma2012

    • Author(s)
      T Negoro, Y Yamamoto, S Shimizu, AH Banham, G Roncador, H Wakabayashi, T Osabe, T Yanai, H Akiyama, K Itabashi and Y Nakano
    • Total Pages
      260
    • Publisher
      InTech
    • Related Report
      2012 Research-status Report
  • [Remarks] 昭和大学学術業績リポジトリ

    • URL

      http://meta.lilitory.showa-u.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 昭和大学薬学部薬物療法学講座遺伝解析薬学部門 2013業績

    • URL

      http://www.showa-u.ac.jp/sch/pharm/major/medinfo/rsch_achievement/2013.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 昭和大学薬学部薬物療法学講座遺伝解析薬学部門 2012年業績

    • URL

      http://www.showa-u.ac.jp/sch/pharm/major/medinfo/rsch_achievement/2012.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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