| Project/Area Number |
24591473
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURIBAYASHI Futoshi 川崎医科大学, 医学部, 教授 (60251443)
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| Research Collaborator |
YAMAUCHI Mikako (DEGAWA Mikako) フェニックスメディカルクリニック, 内科, 部長
KANEGASAKI Shiro Yeungnam University
TSUCHIYA Tomoko Yeungnam University
KOBIKI Kayoko 川崎医科大学, 医学部, 実験補助員
ITADANI Masumi 川崎医科大学, 医学部, 実験補助員
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 走化性 / 好中球 / ケモカイン / 脂質メディエータ / 炎症 / fMLP / IL-8 / PAF / 細胞走化性 / FPR1-PAFRキメラ遺伝子 / FPR1 / PAFR / GPCR / 脂質 / 脂質メディエーター / 走化性因子 / シグナル伝達 / 骨髄系細胞 |
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| Outline of Final Research Achievements |
To clarify the mechanism of pathogenesis in inflammatory diseases, we analyzed chemotaxis pattern of neutrophils to chemoattractants. The migration pattern to fMLP or IL-8 was linear, but the pattern to LTB4 or PAF was winding and twisting. The linear pattern of migration to fMLP or IL-8 was related to the unipolar and stable morphology of the cells. By contrast, the winding and twisting pattern of migration to LTB4 or PAF was related to the multipolar and unstable morphology. Also, we found that the priority order among these 4 ligands in neutrophil chemotaxis was as follows: fMLP > IL-8 >> LTB4 = PAF. These findings contribute to controlling inflammation and the development of new anti-inflammatory agents.
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