Understanding of interaction between immunological and non-immunological mechanisms for development of atopic dermatitis

• Project/Area Number: 24591474
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: YASUDA Takuwa 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 (00373374)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: アトピー性皮膚炎 / 好塩基球

Outline of Final Research Achievements

In this study, using a newly generated mutant mouse (Spade mouse), which spontaneous develops atopic dermatitis like skin disease, we investigated a responsible cells and factors for development of dermatitis.
Our data showed that basophils played a pivotal role in development of dermatitis in our Spade mouse model. Our results suggested that basophils were activated by TSLP and/or IL-33, and then, basophils secreted IL-4 and IL-13, those induced allergic responses directly or regulated inflammatory cells such as eosinophils, neutrophils and macrophages.