| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
In this study, we focused the innate immune system in host, and examined the relationship between prion infection and the immune system. As a result, we revealed that IRF3-type I IFNs system plays a key role in prion infection and that the expression of Oct-1, which is a selectively transcription factor of IRF3 gene, is negatively controlled by prion infection. Consequently, we consider that development of prevention and therapeutic agent against the prion disease, which targets this innate immune system, would progress by our project.
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