The elucidation of prion infectious mechanism on host innate immunity
Project/Area Number |
24591482
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Infectious disease medicine
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Research Institution | Nagasaki University |
Principal Investigator |
ISHIBASHI Daisuke 長崎大学, 医歯薬学総合研究科(医学系), 助教 (10432973)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | prion / innate immunity / IRF3 / IFN / Oct-1 / プリオン / 自然免疫 / ISGs |
Outline of Final Research Achievements |
In this study, we focused the innate immune system in host, and examined the relationship between prion infection and the immune system. As a result, we revealed that IRF3-type I IFNs system plays a key role in prion infection and that the expression of Oct-1, which is a selectively transcription factor of IRF3 gene, is negatively controlled by prion infection. Consequently, we consider that development of prevention and therapeutic agent against the prion disease, which targets this innate immune system, would progress by our project.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] FK506reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice.2013
Author(s)
Nakagaki T, Satoh K, Ishibashi D, Fuse T, Sano K, Kamatari YO, Kuwata K, Shigematsu K, Iwamaru Y, Takenouchi T, Kitani H, Nishida N, Atarashi R.
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Journal Title
Autophagy.
Volume: 9
Issue: 9
Pages: 1386-1394
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Direct evidence of generation and accumulation of β-sheet-rich prion protein in ScN2a cells de novo illuminated by human IgG1 antibody recognizing β-form but not α-form of prion protein2012
Author(s)
Toshiya Kubota, Yuta Hamazoe, Shuhei Hashiguchi, Daisuke Ishibashi, Kazuyuki Akasaka, Noriyuki Nishida, Shigeru Katamine, Suehiro Sakaguchi, Ryota Kuroki, Toshihiro Nakashima, Kazuhisa Sugimura.
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Journal Title
The Journal of biological chemistry
Volume: 287巻
Issue: 17
Pages: 14023-14039
DOI
Related Report
Peer Reviewed
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[Presentation] FK506 reduces abnomal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice2013
Author(s)
Takehiro Nakagaki, Katsuya Satoh, Daisuke Ishibashi, Takayuki Fuse, Kazunori Sano, Yuji O. Kamatari, Kazuo Kuwata, Kazuo Shigematsu, Yoshifumi Iwamaru, Takato Takenouchi, Hiroshi Kitani, Noriyuki Nishida, Ryuichiro Atarashi
Organizer
Asian pacific prion symposium 2013 in Nagasaki(APPS2013)
Place of Presentation
ハウステンボス(長崎県佐世保市)
Related Report
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