Research Project
Grant-in-Aid for Scientific Research (C)
HIV-1infection/AIDS became a controllable disease following continuous advancement of combination antiretroviral therapy (cART). However, pathogenic process that is caused by residual viral replication under effective cART has been noticed as a major problem in the long-term control of HIV-1 infected patients. In this study we established assay system to measure antibody-dependent cell-mediated cytotoxicity (ADCC) aiming toward elimination of HIV-1 infected cell using a panel of neutralizing monoclonal antibodies and identified the antibody response that is effective for ADCC. We also found a patient who had broad neutralizing activity against 22 pseudoviruses of 7 different subtypes and identified epitope recognized by the antiserum in V2/V3 region of gp120.
All 2015 2014 2013 2012 Other
All Journal Article (13 results) (of which Peer Reviewed: 13 results, Open Access: 2 results, Acknowledgement Compliant: 2 results) Presentation (37 results) Remarks (1 results)
AIDS
Volume: 29 Issue: 4 Pages: 453-462
10.1097/qad.0000000000000570
Virology
Volume: 475 Pages: 187-203
10.1016/j.virol.2014.11.011
The FASEB Journal
Volume: 29 Issue: 1 Pages: 1-11
10.1096/fj.14-252262
Journal of General Virology
Volume: 95 Issue: 8 Pages: 1816-1826
10.1099/vir.0.062885-0
Bioorg. Med. Chem.
Volume: 21 Issue: 24 Pages: 7884-7889
10.1016/j.bmc.2013.10.005
J. Gen. Virol.
Volume: 94 Issue: 12 Pages: 2710-2716
10.1099/vir.0.055590-0
Internal Medicine
Volume: 52 Issue: 7 Pages: 735-744
10.2169/internalmedicine.52.9155
130003365967
Volume: 8 Issue: 9 Pages: 2518-2526
10.1016/j.bmc.2013.02.041
J Virol.
Volume: in press Issue: 10 Pages: 933-943
10.1128/jvi.00201-13
Frontiers in Microbiology/Virology.
Volume: 4 Pages: 1-7
10.3389/fmicb.2013.00117
Volume: 94 Issue: 5 Pages: 933-943
10.1099/vir.0.047167-0
PLoS ONE
Volume: 7 Issue: 5 Pages: 1-9
10.1371/journal.pone.0037530
Cellular and molecular biology
Volume: 58 Pages: 71-79
http://matsushita-lab.kumamoto-univ.jp