| Project/Area Number |
24591487
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KADOTA Junichi 大分大学, 医学部, 教授 (50233838)
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| Research Collaborator |
KUSHIMA Hisako
TOBA Satoshi
KAWANO Rie
TANABE Kouichi
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 薬剤耐性 / 真菌症 / 日和見感染症 / 院内感染対策 / 抗菌薬適正使用 / 薬剤耐性菌 |
|---|
| Outline of Final Research Achievements |
The amino acid substitution and the structure change caused the high resistance to antifungal resistance in pathogenic fungi, Trichosporon, which is the ubiquitous yeast around the world. This fungus have the mutant selection window (MSW) around the minimal concentration as the results of in vivo and in vitro studies and analysis.
Besides the use of antifungal agents, by formation of a biofilm, the yeast was also found to resistance of the anti-fungal agent. The antifungals is not effective to the biofilm formation cells of this yeast.
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