Study of mechanism and control of bacterial translocation from the gastrointestinal tract
Project/Area Number |
24591491
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Infectious disease medicine
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Research Institution | Tokyo Medical University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | バクテリアル・トランスロケーション / 腸内細菌 / プロバイオティクス / 緑膿菌 / サルモネラ / 菌血症・敗血症 / 炎症性腸疾患 |
Outline of Final Research Achievements |
Bacterial translocation (BT) is defined as the passage of viable bacteria from the gastrointestinal tract to extraintestinal sites via lymphatic and/or blood vessel routes. We studied the mechanisms of BT by using immunosuppressive mouse model with cyclophosphamide treatment and the results showed intragastric administration of Pseudomonas aeruginosa frequently cause systemic spread of translocating bacteria to cause lethal sepsis. Administration of ampicillin induced exacerbation of BT and sepsis.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] In vivo challenging of polymyxins and levofloxacin eye drop against multidrug-resistant Pseudomonas aeruginosa keratitis.2014
Author(s)
Tajima K, Miyake T, Koike N, Hattori T, Kumakura S, Yamaguchi T, Matsumoto T, Fujita K, Kuroda M, Ito N, Goto H.
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Journal Title
J Infect Chemother.
Volume: 20
Issue: 6
Pages: 343-349
DOI
Related Report
Peer Reviewed
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