Electroencephalogram analysis regarding pathophysiological mechanisms of epileptic cognitive disorders in childhood
Project/Area Number |
24591513
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Okayama University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
YOSHINAGA Harumi 国立病院機構南岡山医療センター, 特命副院長 (00230780)
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Project Period (FY) |
2012-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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Keywords | てんかん性脳症 / 脳波異常 / 高周波振動 |
Outline of Final Research Achievements |
In childhood epileptic encephalopathy in which epileptic activity itself may contribute to severe cognitive and behavioral impairments, we have detected an enormous amount of high-frequency/fast oscillations (HFOs/FOs) with frequencies far beyond the traditional limit from scalp electroencephalogram (EEG) data. We found that epileptic FOs represent disease severity in West syndrome and that intensity of epileptic HFOs corresponds to the degree of EEG abnormalities in various childhood epilepsies with spikes during sleep. It was thus indicated that stormy generation of pathological HFOs/FOs might cause impairment of higher brain functions by interfering with physiological high-frequency brain activity related to cognition.
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Report
(6 results)
Research Products
(23 results)
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[Journal Article] The identification of distinct high-frequency oscillations during spikes delineates the seizure onset zone better than high-frequency spectral power changes2016
Author(s)
Jacobs, J., Vogt, C., LeVan, P., Zelmann, R., Gotman, J., Kobayashi, K.
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Journal Title
Clinical Neurophysiology
Volume: 127
Issue: 1
Pages: 129-142
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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