Electroencephalogram analysis regarding pathophysiological mechanisms of epileptic cognitive disorders in childhood

• Project/Area Number: 24591513
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Okayama University
• Principal Investigator: Kobayashi Katsuhiro 岡山大学, 医歯薬学総合研究科, 教授 (60273984)
• Co-Investigator(Renkei-kenkyūsha): YOSHINAGA Harumi 国立病院機構南岡山医療センター, 特命副院長 (00230780)
• Project Period (FY): 2012-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: てんかん性脳症 / 脳波異常 / 高周波振動

Outline of Final Research Achievements

In childhood epileptic encephalopathy in which epileptic activity itself may contribute to severe cognitive and behavioral impairments, we have detected an enormous amount of high-frequency/fast oscillations (HFOs/FOs) with frequencies far beyond the traditional limit from scalp electroencephalogram (EEG) data. We found that epileptic FOs represent disease severity in West syndrome and that intensity of epileptic HFOs corresponds to the degree of EEG abnormalities in various childhood epilepsies with spikes during sleep. It was thus indicated that stormy generation of pathological HFOs/FOs might cause impairment of higher brain functions by interfering with physiological high-frequency brain activity related to cognition.

Research Products

• [Int'l Joint Research] McGill University(カナダ)
• [Int'l Joint Research] University Medical Center Freiburg(ドイツ)
• [Int'l Joint Research] McGill Univeristy(カナダ)
• [Int'l Joint Research] Freiburg University(ドイツ)
• [Journal Article] Fast (40-150Hz) oscillations are associated with positive slow waves in the ictal EEGs of epileptic spasms in West syndrome (2016)
  • Author(s): Kobayashi, K., Akiyama, T., Oka, M., Endoh, F., Yoshinaga, H
  • Journal Title: Brain and Development Volume: 38 Issue: 10 Pages: 909-914
  • DOI: 10.1016/j.braindev.2016.05.005
  • Peer Reviewed
• [Journal Article] The identification of distinct high-frequency oscillations during spikes delineates the seizure onset zone better than high-frequency spectral power changes (2016)
  • Author(s): Jacobs, J., Vogt, C., LeVan, P., Zelmann, R., Gotman, J., Kobayashi, K.
  • Journal Title: Clinical Neurophysiology Volume: 127 Issue: 1 Pages: 129-142
  • DOI: 10.1016/j.clinph.2015.04.053
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Occurrence of bilaterally independent epileptic spasms after a corpus callosotomy in West syndrome (2016)
  • Author(s): Kobayashi K, Endoh F, Toda Y, Oka M, Baba H, Ohtsuka Y, Yoshinaga H
  • Journal Title: Brain Dev Volume: 38 Issue: 1 Pages: 132-135
  • DOI: 10.1016/j.braindev.2015.05.003
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A storm of fast (40-150 Hz) oscillations during hypsarrhythmia in West syndrome. (2015)
  • Author(s): Kobayashi K, Akiyama T, Oka M, Endoh F, Yoshinaga H.
  • Journal Title: Ann Neurol Volume: 77 Issue: 1 Pages: 58-67
  • DOI: 10.1002/ana.24299
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] High-frequency EEG activity in epileptic encephalopathy with suppression-burst. (2015)
  • Author(s): Toda Y, Kobayashi K, Hayashi Y, Inoue T, Oka M, Endoh F, Yoshinaga H, Ohtsuka Y.
  • Journal Title: Brain Dev Volume: 37 Issue: 2 Pages: 230-236
  • DOI: 10.1016/j.braindev.2014.04.004
  • Peer Reviewed
• [Journal Article] Effects of intravenous diazepam on high-frequency oscillations in EEGs with CSWS (2013)
  • Author(s): Toda Y, Kobayashi K, Hayashi Y, Inoue T, Oka M, Ohtsuka Y
  • Journal Title: Brain Dev Volume: 35 Issue: 6 Pages: 540-547
  • DOI: 10.1016/j.braindev.2012.09.002
  • Peer Reviewed
• [Journal Article] Cortical contribution to scalp EEG gamma rhythms associated with epileptic spasms (2013)
  • Author(s): Kobayashi K, Miya K, Akiyama T, Endoh F, Oka M, Yoshinaga H, Ohtsuka Y
  • Journal Title: Brain Dev Volume: 35 Issue: 8 Pages: 762-770
  • DOI: 10.1016/j.braindev.2012.12.012
  • Peer Reviewed
• [Journal Article] Clinical analysis of catastrophic epilepsy in infancy and early childhood: results of the Far-East Asia Catastrophic Epilepsy (FACE) study group (2013)
  • Author(s): Oguni H, Otsuki T, Kobayashi K, et al.
  • Journal Title: Brain Dev Volume: 35 Issue: 8 Pages: 786-792
  • DOI: 10.1016/j.braindev.2013.02.004
  • Peer Reviewed
• [Journal Article] Questionnaire-based assessment of behavioral problems in Japanese children with epilepsy. (2013)
  • Author(s): Kobayashi K, Endoh F, Ogino T, Oka M, Morooka T, Yoshinaga H, Ohtsuka Y.
  • Journal Title: Epilepsy Behav Volume: 27 Issue: 1 Pages: 238-242
  • DOI: 10.1016/j.yebeh.2013.01.020
  • Peer Reviewed
• [Presentation] Scalp HFOs in various childhood epilepsies (2016)
  • Author(s): Kobayashi K
  • Organizer: 2nd International Workshop on High Frequency Oscillations in Epilepsy-A scientific and teaching workshop
  • Place of Presentation: Freiburg, Germany
  • Year and Date: 2016-03-10
  • Int'l Joint Research / Invited
• [Presentation] 小児てんかんの脳波分析による病態解明 (2016)
  • Author(s): 小林勝弘
  • Organizer: 第 46 回日本臨床神経生理学会学術大会
  • Place of Presentation: 福島
  • Invited
• [Presentation] 小児てんかんとオシロロジー (2016)
  • Author(s): 小林勝弘
  • Organizer: 第 57 回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Invited
• [Presentation] A storm of fast (40-150 Hz) oscillations during hypsarrhythmia in West syndrome (2015)
  • Author(s): Kobayashi K, Akiyama T, Oka M, Endoh F, Yoshinaga H
  • Organizer: 69th Annual Meeting of the American Epilepsy Society
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] 頭皮脳波における高周波振動検出のスキル (2015)
  • Author(s): 小林勝弘
  • Organizer: 第 45 回日本臨床神経生理学会学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2015-11-06
  • Invited
• [Presentation] 小児脳波研究の最前線 (2015)
  • Author(s): 小林勝弘
  • Organizer: 第 45 回日本臨床神経生理学会学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2015-11-06
  • Invited
• [Presentation] 脳波解析が明かすてんかんの病態―基礎から最前線まで― (2015)
  • Author(s): 小林勝弘
  • Organizer: 第8回日本てんかん学会東海・北陸地方会イブニングセミナー
  • Place of Presentation: 富山
  • Year and Date: 2015-07-11
  • Invited
• [Presentation] てんかん性高周波振動の発生プロセスを探る (2014)
  • Author(s): 小林勝弘、秋山倫之
  • Organizer: 神経オシレーションカンファレンス
  • Place of Presentation: 岡崎
  • Year and Date: 2014-07-18
  • Invited
• [Presentation] 難治小児てんかんの電気生理―特に異常高周波活動と病態との関係について― (2013)
  • Author(s): 小林勝弘、東田好広
  • Organizer: 第 55 回日本小児神経学会
  • Place of Presentation: 東京
  • Invited
• [Book] Annual Review神経2017 (2017)
  • Author(s): 小林勝弘
  • Total Pages: 281
  • Publisher: 中外医学社