| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Several signaling-molecule genes for brain-derived neurotrophic factor (bdnf) have been known as risk factors of autistic spectrum disorders and the social-related behavioral abnormalities. In this study, we found that significant deficits in the social behaviors of bdnf heterozygous knock out (bdnf+/-) mice. Further investigations revealed that whisker tactile sensation, important for social behaviors, were comparable in bdnf+/- and wild-type mice; however bdnf+/- mice had learning disabilities of whisker-cued maze task and that hyperactivities in limbic systems of bdnf+/- mice were significantly increased comparing to those of wild-type when induced by height-stress. These functional abnormalities in the brain would affect the social behavior of bdnf-deficient mice.
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