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Cross talk of nuclear receptors regulating lipid levels of breast milk

Research Project

Project/Area Number 24591530
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionOsaka Medical College

Principal Investigator

TAKITANI KIMITAKA  大阪医科大学, 医学部, 講師 (80319540)

Co-Investigator(Kenkyū-buntansha) TAMAI Hiroshi  大阪医科大学, 医学部, 教授 (30179874)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords母乳 / 脂質 / 核内受容体
Outline of Final Research Achievements

Nutrition of breast-feeding is the most appropriate of all available milks for human infants. Human milk contains lysozyme, and lactofarin, secretary IgA antibodies, which provide gastrointestinal immunity. The composition of breast milk including minerals, prorotein and fats is changed during laction, however, the regulation of them is not clear. In the study, we investigated whether lipid metabolism related - nuclear receptor superfamily may affect the lipid contents of breast milk. The present study demonstrataed that transcriptional nuclear receptors have critical role for regulating the lipid levels of breast milk during lactation.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2015 2014 2013 2012

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 1 results) Presentation (7 results) (of which Invited: 1 results)

  • [Journal Article] Association of thyroid hormones with obesity and metabolic syndrome in Japanese children.2015

    • Author(s)
      Minami Y, Takaya R, Takitani K, Ishiro M, Okasora K, Niegawa T, Tamai H.
    • Journal Title

      J Clin Biochem Nutr.

      Volume: 57

    • NAID

      130005096227

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered retinol status and expression of retinol-related proteins in streptozotocin-induced type 1 diabetic model rats.2015

    • Author(s)
      Takitani K, Inoue K, Koh M, Miyazaki H, Kishi K, Inoue A, Tamai H.
    • Journal Title

      J Clin Biochem Nutr.

      Volume: 56 Pages: 195-200

    • NAID

      130005068186

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α-Tocopherol Status and Altered Expression of α-Tocopherol-Related Proteins in Streptozotocin-Induced Type 1 Diabetes in Rat Models2014

    • Author(s)
      Takitani K, Inoue K, Koh M, Miyazaki H, Kishi K, Inoue A, Tamai H.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 60 Issue: 6 Pages: 380-386

    • DOI

      10.3177/jnsv.60.380

    • NAID

      130005060910

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retinol status and expression of retinol-related proteins in methionine-choline deficient rats.2014

    • Author(s)
      Miyazaki H, Takitani K, Koh M, Inoue A, Kishi K, Tamai H.
    • Journal Title

      J Nutr Sci Vitaminol.

      Volume: 60 Pages: 78-85

    • NAID

      130004491369

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The α-tocopherol status and expression of α-tocopherol-related proteins in methionine-choline deficient rats treated with vitamin E2014

    • Author(s)
      Miyazaki H, Takitani K, Koh M, Yoden A, Tamai H.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 54 Issue: 3 Pages: 190-197

    • DOI

      10.3164/jcbn.13-74

    • NAID

      130004466749

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver X receptor up-regulates α-tocopherol transfer protein expression and α-tocopherol status.2013

    • Author(s)
      Koh M, Takitani K, Miyazaki H, Yamaoka S, Tamai H.
    • Journal Title

      J Nutr Biochem.

      Volume: 24 Issue: 12 Pages: 2158-67

    • DOI

      10.1016/j.jnutbio.2013.08.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case treated with triple therapy of lamivudine, interferon-β and prednisolone for acute exacerbation of chronic hepatitis B during pregnancy.2013

    • Author(s)
      Koh M, Shinohara J, Hongo Y, Okazaki T, Takitani K, Tamai H.
    • Journal Title

      Hepatol Res.

      Volume: 43 Issue: 4 Pages: 425-9

    • DOI

      10.1111/j.1872-034x.2012.01077.x

    • NAID

      10031194555

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] α-Tocopherol status and expression of α-tocopherol transfer protein in type 2 diabetic Goto-Kakizaki rats.2013

    • Author(s)
      Miyazaki H, Takitani K, Koh M, Takaya R, Yoden A, Tamai H.
    • Journal Title

      J Nutr Sci Vitaminol.

      Volume: 59 Pages: 64-8

    • NAID

      130003368150

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of uric acid with obesity and endothelial dysfunction in children and early adolescents.2013

    • Author(s)
      Ishiro M, Takaya R, Mori Y, Takitani K, Kono Y, Okasora K, Kasahara T, Tamai H.
    • Journal Title

      Ann Nutr Metab.

      Volume: 62 Issue: 2 Pages: 169-76

    • DOI

      10.1159/000346227

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] GNB3 C825T polymorphism is associated with postural tachycardia syndrome in children.2012

    • Author(s)
      Nakao R, Tanaka H, Takitani K, Kajiura M, Okamoto N, Kanbara Y, Tamai H.
    • Journal Title

      Pediatr Int.

      Volume: 54 Issue: 6 Pages: 829-37

    • DOI

      10.1111/j.1442-200x.2012.03707.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vitamin E decreases bone mass by stimulating osteoclast fusion2012

    • Author(s)
      Fujita K, et al
    • Journal Title

      Nat Med

      Volume: 18 Issue: 4 Pages: 589

    • DOI

      10.1038/nm.2659

    • URL

      https://localhost/en/publications/fc70e750-6e59-4813-bc13-47059a99d642

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 母乳におけるビタミンE濃度調節因子の検討2015

    • Author(s)
      瀧谷公隆、洪 真紀、玉井 浩
    • Organizer
      第26回 ビタミンE研究会
    • Place of Presentation
      東京 北里大学薬学部コンベンションホール
    • Year and Date
      2015-01-09 – 2015-01-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 「栄養と臨床におけるビタミンの遺伝子多型に基づいたテーラーメイド摂取の有用性」 脂溶性ビタミンと遺伝子多型:代謝および疾患との関連2014

    • Author(s)
      瀧谷公隆
    • Organizer
      第66回日本ビタミン学会
    • Place of Presentation
      兵庫県姫路市 姫路商工会議所
    • Year and Date
      2014-06-13 – 2014-06-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 疾患におけるビタミンE濃度調節機構2013

    • Author(s)
      瀧谷公隆
    • Organizer
      第65回 日本ビタミン学会 学術集会
    • Place of Presentation
      一橋大学、一橋講堂、東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 糖尿病モデルラットにおけるレチノール代謝に関する検討2013

    • Author(s)
      瀧谷公隆、玉井浩
    • Organizer
      第24回 日本レチノイド研究会 学術集会
    • Place of Presentation
      星薬科大学、東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 尿細管障害モデルラットにおけるレチノール代謝に関する検討2012

    • Author(s)
      瀧谷公隆、玉城裕史、宮崎敬士、玉井浩
    • Organizer
      第64回 日本ビタミン学会 学術集会
    • Place of Presentation
      長良川国際会議場、岐阜市
    • Related Report
      2012 Research-status Report
  • [Presentation] 腎疾患モデルラットにおけるレチノール代謝に関する検討2012

    • Author(s)
      瀧谷公隆、玉井浩
    • Organizer
      第23回 日本レチノイド研究会 学術集会
    • Place of Presentation
      米子コンベンションセンター、米子市
    • Related Report
      2012 Research-status Report
  • [Presentation] Dehydroepiandrosterone alters tocopherol levels and expression of tocopherol transfer protein2012

    • Author(s)
      Kimitaka Takitani, Hiroshi Miyazaki, Hiroshi Tamai
    • Organizer
      The 2012 Annual Meeting of the Canadian Society of Pharmacology and Therapeutics
    • Place of Presentation
      University of Toronto、Toronto, Canada
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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