| Project/Area Number |
24591533
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWATA Osuke 久留米大学, 小児科, 准教授 (30465710)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 新生児 / 睡眠 / Actigraphy / コルチゾール / サーカディアンリズム / 認知障害 / 睡眠障害 |
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| Outline of Final Research Achievements |
It is largely unknown how foetal biological rhythms evolve into adult-type circadian rhythms, which are observed approximately 12 weeks of life. Using actigraphy and salivary biomarkers, we observed that diurnal rhythms, which mimic those of foetuses, can be observed even shortly after birth. In a large cohort of healthy one-month-old infants and their mothers, the infant’s nighttime sleep was dependent on both maternal life styles and intrinsic variables of the infant. Taken together, development of diurnal rhythms after birth is likely to be regulated by both extrinsic stimuli (e.g. maternal melatonin and lifestyle) and intrinsic programme (e.g. genetic factors).
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