| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Non-herpetic acute limbic encephalitis is the encephalitis related with antibodies to NMDA-type GluRs, which have important roles in CNS function. We have not revealed the immunopathology for production of antibodies to NMDA-type GluRs. In this study, we found that antigens for the antibodies derived from NMDA-type GluRs expressed on surface of lymphocytes and platelets in sera and CSF. We developed the quantitative measurement of IgG subclass of antibodies to GluN2B-NT2, and found that quantity of IgG3 subclass was related with sequelae, e.g. epilepsy, cognitive dysfunction, motor disturbance.
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