Study of immuno-pathophysiology and application for treatment in non-herpetic acute limbic encephalitis: origin of autoantigens and subclass of antibodies

• Project/Area Number: 24591537
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
• Principal Investigator: TAKAHASHI Yukitoshi 独立行政法人国立病院機構(静岡・てんかん神経医療センター臨床研究部), その他部局等, その他 (70262764)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: GluN2B / GluN1 / 自己抗体 / IgGサブクラス / Fas / FasL / IgGサブクラス抗体 / GranzymeB / 自己免疫介在性脳炎 / グルタミン酸受容体 / 細胞傷害性T細胞 / 制御性T細胞

Outline of Final Research Achievements

Non-herpetic acute limbic encephalitis is the encephalitis related with antibodies to NMDA-type GluRs, which have important roles in CNS function. We have not revealed the immunopathology for production of antibodies to NMDA-type GluRs. In this study, we found that antigens for the antibodies derived from NMDA-type GluRs expressed on surface of lymphocytes and platelets in sera and CSF. We developed the quantitative measurement of IgG subclass of antibodies to GluN2B-NT2, and found that quantity of IgG3 subclass was related with sequelae, e.g. epilepsy, cognitive dysfunction, motor disturbance.

Research Products

• [Journal Article] A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma. (2014)
  • Author(s): Armangue T, Titulaer MJ, Sabater L, Pardo-Moreno J, Gresa-Arribas N, Barbero-Bordallo N, Kelley GR, Kyung-Ha N, Takeda A, Nagao T, Takahashi Y, Lizcano A, Carr AS, Graus F, Dalmau J
  • Journal Title: Ann Neurol Volume: 75 Issue: 3 Pages: 435-441
  • DOI: 10.1002/ana.23917
  • Peer Reviewed
• [Journal Article] Brain perfusion SPECT in limbic encephalitis associated with autoantibody against the glutamate receptor epsilon 2 (2014)
  • Author(s): Kimura N, Kumamoto T, Takahashi Y
  • Journal Title: Clin Neurol Neurosurg Volume: 118 Pages: 44-48
  • DOI: 10.1016/j.clineuro.2013.12.006
  • Peer Reviewed
• [Journal Article] Multifocal Encephalopathy and Autoimmune-mediated Limbic Encephalitis Following Tocilizumab Therapy (2014)
  • Author(s): Yamaguchi Y, Furukawa K, Yamamoto T, Takahashi Y, Tanaka K, Takahashi M.
  • Journal Title: Intern Med Volume: 53 Pages: 879-882
  • NAID: 130003392762
  • Peer Reviewed / Open Access
• [Journal Article] Another case of respiratory syncytial virus-related limbic encephalitis (2014)
  • Author(s): Kengo Moriyama, Yukitoshi Takahashi, Takashi Shiihara
  • Journal Title: Neuroradiology Volume: 56 Issue: 5 Pages: 435-436
  • DOI: 10.1007/s00234-014-1350-2
  • Peer Reviewed
• [Journal Article] Chronic periodic lateralised epileptic discharges and anti-N-methyl-D-aspartate receptor antibodies (2014)
  • Author(s): Sakakibara E, Takahashi Y, Murata Y, Taniguchi G, Sone D, Watanabe M.
  • Journal Title: Epileptic Disord Volume: 16 Issue: 2 Pages: 218-222
  • DOI: 10.1684/epd.2014.0655
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Limbic encephalitis-associated relapsing polychondritis responded to infliximab and maintained its condition without recurrence after discontinuation –a case report and review of the literature (2014)
  • Author(s): Takeshi Kondo, Mamiko Fukata, Ayumu Takemoto, Yuichiro Takami, Motoki Sato, Noriyuki Takahashi, Tomo Suzuki, Juichi Sato, Naoki Atsuta, Gen Sobue, Yukitoshi Takahashi, Nobutaro Ban
  • Journal Title: Nagoya journal Volume: 76 Pages: 361-368
  • Peer Reviewed / Open Access
• [Journal Article] Developmental outcome after surgery in focal cortical dysplasia patients with early-onset epilepsy (2014)
  • Author(s): Nobusuke Kimura, Yukitoshi Takahashi, Hideo Shigematsu, Katsumi Imai, Hiroko Ikeda, Hideyuki Ootani, Rumiko Takayama, Yukiko Mogami, Noriko Kimura, Koichi Baba, Kazumi Matsuda, Takayasu Tottori, Naotaka Usui, Yushi Inoue
  • Journal Title: Epilepsy Research Volume: 108 Issue: 10 Pages: 1845-1852
  • DOI: 10.1016/j.eplepsyres.2014.09.010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Lymphopenia Helps Early Diagnosis of Systemic Lupus Erythematosus for Patients With Psychosis as an Initial Symptom. (2014)
  • Author(s): Chiba Y, Katsuse O, Fujishiro H, Kamada A, Saito T, Ikura T, Takahashi Y,Kunii M, Takeno M, Hirayasu Y.
  • Journal Title: Psychosomatics. Volume: Epub ahead of print Issue: 1 Pages: 85-88
  • DOI: 10.1016/j.psym.2013.07.001
  • Peer Reviewed
• [Journal Article] 急性無菌性髄膜脳炎の経過中に局所性皮質反射性ミオクローヌスを呈し抗グルタミン酸受容体抗体が検出された2例 (2014)
  • Author(s): 戸島 麻耶、人見健文、陣上直人、谷岡洸介、山門穂高、松本理器、高橋幸利、池田昭夫、髙橋良輔
  • Journal Title: 臨床神経学 Volume: 54 Pages: 543-549
  • NAID: 130004678995
  • Peer Reviewed / Open Access
• [Journal Article] 免疫介在性神経疾患 (2014)
  • Author(s): 高橋幸利、森達夫、大星大観、束本和紀、渡辺陽和、吉富晋作、山口解冬
  • Journal Title: 小児感染免疫 Volume: 26 Pages: 403-414
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 神経疾患とNMDA型グルタミン酸受容体抗体 (2014)
  • Author(s): 高橋幸利、森達夫、大星大観、束本和紀、渡辺陽和、吉富晋作、山口解冬
  • Journal Title: 日本小児科学会誌 Volume: 118 Pages: 1695-1707
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma (2014)
  • Author(s): Armangue T, Takahashi Y, et al.
  • Journal Title: Ann Neurol Volume: in press
  • Peer Reviewed
• [Journal Article] Anti-NMDAR autoimmune encephalitis (2014)
  • Author(s): Kazushi Miya, Yukitoshi Takahashi, et al.
  • Journal Title: Brain & Development Volume: in press
  • Peer Reviewed
• [Journal Article] Anti-NMDAR autoimmune encephalitis. (2013)
  • Author(s): Miya K, Takahashi Y, Mori H.
  • Journal Title: Brain Dev. Volume: 13 Issue: 8 Pages: 295-297
  • DOI: 10.1016/j.braindev.2013.10.005
  • Peer Reviewed
• [Journal Article] A mild form of adult-onset opsoclonus-myoclonus syndrome associated with anti-glutamate receptor antibodies (2013)
  • Author(s): Taiki Kambe, Yukitoshi Takahashi, et al.,
  • Journal Title: JAMA Neurology Volume: 70 Pages: 654-655
  • Peer Reviewed
• [Journal Article] A discrepancy between the clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitis (2013)
  • Author(s): Naoto Kohno, Yukitoshi Takahashi, et al.,
  • Journal Title: Neurology International Volume: 5 Pages: 23-27
  • Peer Reviewed
• [Journal Article] Genetic variations of immunoregulatory genes associated with Rasmussen syndrome (2013)
  • Author(s): Yukitoshi Takahashi, et al.,
  • Journal Title: Epilepsy Research Volume: 107 Pages: 238-243
  • Peer Reviewed
• [Journal Article] Immunopathological significance of ovarian teratoma in patients with anti-N-methyl-D-aspartate receptor encephalitis (2013)
  • Author(s): Emi Tabata, Yukitoshi Takahashi, et al.
  • Journal Title: Eur Neurol Volume: 71 Pages: 42-48
  • Peer Reviewed
• [Journal Article] A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.Pharmacogenomics J (2013)
  • Author(s): Tohkin M, Kaniwa N, Saito Y, Sugiyama E, Kurose K, Nishikawa J, Hasegawa R, Aihara M, Matsunaga K, Abe M, Furuya H, Takahashi Y, Ikeda H, Muramatsu M, Ueta M, Sotozono C, Kinoshita S, Ikezawa Z
  • Journal Title: Peer-Reviewed papers Volume: 13(1) Issue: 1 Pages: 60-69
  • DOI: 10.1038/tpj.2011.41
  • Peer Reviewed
• [Journal Article] Open study of pranlukast add-on therapy in intractable partial epilepsy, (2013)
  • Author(s): Yukitoshi Takahashi, Katsumi Imai, Hitoshi Ikeda, Yuko Kubota, Etsuko Yamazaki, Fuminobu Susa,
  • Journal Title: Brain & Development Volume: 35 Issue: 3 Pages: 236-244
  • DOI: 10.1016/j.braindev.2012.04.001
  • Peer Reviewed
• [Journal Article] Characteristics of epilepsy and immunological markers in epileptic patients after influenza-associated encephalopathy, (2013)
  • Author(s): Jun Mine, Yukitoshi Takahashi, Yuki Mogami, Hiroko Ikeda, Yuko Kubota, Katsumi Imai,
  • Journal Title: Neurology Asia Volume: 18 Pages: 35-45
  • Peer Reviewed
• [Journal Article] Late delirious behavior with 2009 H1N1 Influenza; mild autoimmune-mediated encephalitis? (2013)
  • Author(s): Jun-ichi Takanashi, Yukitoshi Takahashi, Atsushi Imamura, Kazuhiko Kodama, Akimitsu Watanabe, Koji Tominaga, Kazuhiro Muramatsu, A. James Barkovich
  • Journal Title: Pediatrics Volume: ? Issue: 4 Pages: e1068-e1071
  • DOI: 10.1542/peds.2010-3221
  • Peer Reviewed
• [Journal Article] Voltage-gated potassium channel complex antibodies in Creutzfeldt-Jakob disease (2013)
  • Author(s): Koji Fujita, Tatsuhiko Yuasa, Yukitoshi Takahashi, Keiko Tanaka, Wataru Sako, Hidetaka Koizumi, Yasuhi Iwasaki, Mari Yoshida, Yuishin Izumi, Ryuji Kaji
  • Journal Title: Journal of Neurology, Volume: ? Issue: 10 Pages: 2249-2250
  • DOI: 10.1007/s00415-012-6554-y
  • Peer Reviewed
• [Journal Article] Cerebellar symptoms in a case of acute limbic encephalitis associated with autoantibodies to glutamate receptors epsilon 2 and delta 2. (2013)
  • Author(s): Ryuta Kinno, Takahiro Yamazaki, Masahiro Yamamoto, Yukitoshi Takahashi, Toshiya Fukui, Eriko Kinugasa,
  • Journal Title: Clinical Neurology and Neurosurgery Volume: 115 Issue: 4 Pages: 481-483
  • DOI: 10.1016/j.clineuro.2012.06.011
  • Peer Reviewed
• [Journal Article] Immunomodulatory therapy versus surgery for Rasmussen syndrome in early childhood (2013)
  • Author(s): Yukitoshi Takahashi, Etsuko Yamasaki, Jun Mine, Yuko Kubota, Katsumi Imai, Yuki Mogami, Koichi Baba, Kazumi Matsuda, et al.,
  • Journal Title: Brain & Development Volume: ? Issue: 8 Pages: 778-785
  • DOI: 10.1016/j.braindev.2013.01.010
  • Peer Reviewed
• [Journal Article] Anti-Glutamate Receptor ε2 antibodies in psychiatric patients with anti-thyroid autoantibodies --- a prevalence study in Japan (2013)
  • Author(s): Yuhei Chiba, Omi Katsuse, Yukitoshi Takahashi, Makoto Yoneda, Misako Kunii, Atsushi Ihata, Atsuhisa Ueda, Mitsuhiro Takeno, Takashi Togo, Yoshio Hirayasu,
  • Journal Title: Neuroscience letters Volume: ?
  • Peer Reviewed
• [Journal Article] Influence of CYP2C19 polymorphism and concomitant antiepileptic drugs on serum clobazam and N-desmethyl-clobazam concentrations in patients with epilepsy (2013)
  • Author(s): Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Kou Miyakawa, Shigeko Nishimura, Risa Kasai, Hiroko Ikeda, Rumiko Takayama, Yukiko Mogami, Tokito Yamaguchi, et al.,
  • Journal Title: Therapeutic Drug Monitoring Volume: ?
  • Peer Reviewed
• [Journal Article] Association of acute cerebellar ataxia and human papilloma virus vaccination: a case report" in its current form for publication (2013)
  • Author(s): Chihiro Yonee, Mitsuo Toyoshima, Yoshihiro Maegaki, Shou Hashiguchi, Yuichi Kodama, Yukitoshi Takahashi, Susumu Kusunoki, Yoshifumi Kawano,
  • Journal Title: Neuropediatrics Volume: ?
  • Peer Reviewed
• [Journal Article] A mild form of adult-onset opsoclonus-myoclonus syndrome associated with anti-glutamate receptor antibodies (2013)
  • Author(s): Taiki Kambe, Yukitoshi Takahashi, Yoshiaki Furukawa
  • Journal Title: JAMA Neurology Volume: ?
  • Peer Reviewed
• [Journal Article] Risk factors for hyperammonemia in pediatric epilepsy patients (2013)
  • Author(s): Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Nobuyuki Mishima, Rei Yazawa, Kazuyuki Inoue, Kunihiko Itoh, Yoshiyuki Kagawa, and Yushi Inoue
  • Journal Title: Epilepsia Volume: ? Issue: 6 Pages: 983-989
  • DOI: 10.1111/epi.12125
  • Peer Reviewed
• [Journal Article] A discrepancy between the clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitis (2013)
  • Author(s): Naoto KOHNO, Yuko KAWAKAMI, Chizuko HAMADA, Genya TOYODA, Hirokazu BOKURA, Shuhei YAMAGUCHI, Yukitoshi TAKAHASHI
  • Journal Title: Neurology International Volume: ?
  • Peer Reviewed
• [Journal Article] Anti-N-methyl D-aspartate-type glutamate receptor antibody-positive limbic encephalitis in a patient with multiple sclerosis (2012)
  • Author(s): Uzawa A, Mori M, Takahashi Y, Ogawa Y, Uchiyama T, Kuwabara S
  • Journal Title: Clin Neurol Neurosurg Volume: (in press) Issue: 4 Pages: 402-404
  • DOI: 10.1016/j.clineuro.2011.10.047
  • Peer Reviewed
• [Journal Article] Focal encephalopathy with recurrent episodes of epileptic status and cluster mimicking hemiconvulsion-hemiplegia-epilepsy syndrome. (2012)
  • Author(s): Miyata R et al.
  • Journal Title: Brain Dev. Volume: 34 Issue: 5 Pages: 360-363
  • DOI: 10.1016/j.braindev.2011.06.011
  • Peer Reviewed
• [Journal Article] Cutaneous adverse drug reaction in patients with epilepsy after acute encephalitis (2012)
  • Author(s): Yukiko Mogami, Yukitoshi Takahashi, Rumiko Takayama, Hideyuki Ohtani, Hiroko Ikeda, Katsumi Imai, Hideo Shigematu, Yushi Inoue,
  • Journal Title: Brain & Development Volume: 34 Issue: 6 Pages: 496-503
  • DOI: 10.1016/j.braindev.2011.09.003
  • Peer Reviewed
• [Journal Article] Efficacy of stiripentol in a mouse model of severe myoclonic epilepsy in infancy (2012)
  • Author(s): Dezhi Cao, Hideyuki Ohtani, Ikuo Ogiwara, Sanae Ohtani, Yukitoshi Takahashi, Kazuhiro Yamakawa, Yushi Inoue
  • Journal Title: Epilepsia Volume: 53 Issue: 7 Pages: 1140-1145
  • DOI: 10.1111/j.1528-1167.2012.03497.x
  • Peer Reviewed
• [Journal Article] Self-induced seizures presumably by peri-orbital somatosensory self-stimulation: a report of two cases (2012)
  • Author(s): Rumiko Takayama, Yukitoshi Takahashi, Yukiko Mogami, Mariko Ikegami, Souichi Mukaida, Hiroko Ikeda, Katsumi Imai, Hideo Shigematsu, Yasuhiro Suzuki, Yushi Inoue,
  • Journal Title: Brain & Development Volume: 34 Issue: 8 Pages: 685-690
  • DOI: 10.1016/j.braindev.2011.11.004
  • Peer Reviewed
• [Journal Article] Risk factors for hyperammonemia associated with valproic acid therapy in adult epilepsy patients (2012)
  • Author(s): Yoshiaki Yamamoto, Yukitoshi Takahashi, Eri Suzuki, Nobuyuki Mishima, Kazuyuki Inoue, Kunihiko Itoh, Yoshiyuki Kagawa, Yushi Inoue,
  • Journal Title: Epilepsy Research Volume: 101 Issue: 3 Pages: 202-209
  • DOI: 10.1016/j.eplepsyres.2012.04.001
  • Peer Reviewed
• [Journal Article] An immunologic case study of acute encephalitis with refractory, repetitive partial seizures (2012)
  • Author(s): Hiroyuki Wakamoto, Yukitoshi Takahashi, Tomohiro Ebihara, Kentaro Okamoto, Masatoshi Hayashi, Takashi Ichiyama, Eiichi Ishii
  • Journal Title: Brain & Development Volume: 34 Issue: 9 Pages: 763-767
  • DOI: 10.1016/j.braindev.2011.12.007
  • Peer Reviewed
• [Journal Article] Antibodies to N-methyl-D-aspartate glutamate receptors in Creutzfeldt-Jakob disease patients, (2012)
  • Author(s): Koji Fujita, Tatsuhiko Yuasa, Yukitoshi Takahashi, Keiko Tanaka, Wataru Sako, Hidetaka Koizumi, Yasuhi Iwasaki, Mari Yoshida, Yuishin Izumi, Ryuji Kaji,
  • Journal Title: J Neuroimmunology Volume: 251 Issue: 1-2 Pages: 90-93
  • DOI: 10.1016/j.jneuroim.2012.06.010
  • Peer Reviewed
• [Journal Article] Steroid-responsive focal epilepsy with focal dystonia accompanied by glutamate receptor delta2 antibody, (2012)
  • Author(s): Hideyuki Matsumoto, Shingo Okabe, Minako Hirakawa-Yamada, Yukitoshi Takahashi, Noboru Satoh, Yukifusa Igeta, Hideji Hashida
  • Journal Title: J Neuroimmunol. Volume: 249 Issue: 1-2 Pages: 101-104
  • DOI: 10.1016/j.jneuroim.2012.04.009
  • Peer Reviewed
• [Journal Article] Clinical and radiological features of Japanese patients with a severe phenotype due to CASK mutations. (2012)
  • Author(s): Takanashi J, Okamoto N, Yamamoto Y, Hayashi S, Arai H, Takahashi Y, Maruyama K, Mizuno S, Shimakawa S, Ono H, Oyanagi R, Kubo S, Barkovich AJ, Inazawa J.
  • Journal Title: Am J Med Genet A. Volume: 158A Issue: 12 Pages: 3112-8
  • DOI: 10.1002/ajmg.a.35640
  • Peer Reviewed
• [Journal Article] Anti-glutamate receptor δ2 antibody-positive migrating focal encephalitis (2012)
  • Author(s): Takuya Fukuoka, Hidetaka Takeda, Yasuko Ohe, Ichiro Deguchi, Yukitoshi Takahashi, Norio Tanahashi
  • Journal Title: Clinical Neurology and Neurosurgery Volume: 114 Issue: 10 Pages: 1351-1354
  • DOI: 10.1016/j.clineuro.2012.03.026
  • Peer Reviewed
• [Journal Article] Toxic epidermal necrolysis in a 4-year-old boy successfully treated with plasma exchange in combination with methylprednisolone and i. v. immunoglobulin. (2012)
  • Author(s): Aihara Y, Oyama Y, Ichikawa K, Takeshita S, Takahashi Y, Kambara T, Aihara M
  • Journal Title: J Dermatol Volume: 39 Issue: 11 Pages: 951-952
  • DOI: 10.1111/j.1346-8138.2012.01534.x
  • Peer Reviewed
• [Journal Article] Dysfunction of blood-brain barrier in epileptic patients after acute encephalitis, (2012)
  • Author(s): Meilia M. Suriadi, Yukitoshi Takahashi, Shigeko Nishimura, Hisano Tsunogae, Yushi Inoue1,
  • Journal Title: Epileptologia Volume: 20 Pages: 51-61
  • Peer Reviewed
• [Journal Article] Subacute cerebellar ataxia and atrophy developed in a young woman with systemic lupus erythematosus whose cerebrospinal fluid was positive for antineuronal cell antibody (2011)
  • Author(s): Iwasaki Y, Okamoto A, Shoda H, Takahashi Y, Fujio K, Kawahata K, Yamamoto K
  • Journal Title: Lupus Volume: 21 Issue: 3 Pages: 324-328
  • DOI: 10.1177/0961203311418270
  • Peer Reviewed
• [Journal Article] Cutaneous adverse drug reaction in patients with epilepsy after acute encephalitis (2011)
  • Author(s): Yukiko Mogami, Yukitoshi Takahashi, Rumiko Takayama, Hideyuki Ohtani, Hiroko Ikeda, Katsumi Imai, Hideo Shigematu, Yushi Inoue
  • Journal Title: Brain & Development Volume: 259 Issue: 5 Pages: 985-988
  • DOI: 10.1007/s00415-011-6291-7
  • Peer Reviewed
• [Presentation] 脳炎と脳炎後てんかんの病態・治療 (2015)
  • Author(s): 高橋幸利
  • Organizer: 第9回日本てんかん学会中国・四国地方会
  • Place of Presentation: 徳島
  • Year and Date: 2015-02-07
  • Invited
• [Presentation] NMDA型GluR抗体の機能解明 in vitro & in vivo (2014)
  • Author(s): 高橋幸利
  • Organizer: 第44 回日本臨床神経生理学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-19 – 2014-11-21
  • Invited
• [Presentation] Pre-congress symposium: Update of Rasmussen syndrome：Immunopathogenesis (2014)
  • Author(s): ukitoshi Takahashi
  • Organizer: The 48th Congress of the Japan Epilepsy Society
  • Place of Presentation: 東京
  • Year and Date: 2014-10-01 – 2014-10-03
  • Invited
• [Presentation] シンポジウム 3 脳炎後てんかんの病態・治療を探る、免疫病態 (2014)
  • Author(s): 髙橋幸利、西村成子、高尾恵美子、笠井理沙、平松宏実
  • Organizer: 第56回日本小児神経学会
  • Place of Presentation: 浜松
  • Year and Date: 2014-05-29 – 2014-05-31
  • Invited
• [Presentation] Rasmussen症候群における免疫調節遺伝子のゲノム解析：T-bet（TBX21） (2013)
  • Author(s): 50. 高橋幸利、平松宏実、高尾恵美子、笠井理沙、西村成子、最上友紀子、美根潤、今井克美、小出泰道、松田一己、井上有史、赤坂紀幸、小西高志、今村淳、
  • Organizer: 日本人類遺伝学会 第58回大会
  • Place of Presentation: 仙台
• [Presentation] 非傍腫瘍性抗NMDAR脳炎の病態解明：抗体 IgGサブクラスの検討 (2013)
  • Author(s): 53. 高橋幸利、西村成子、高尾恵美子、笠井理沙、平松宏実、井上有史
  • Organizer: 第25回 日本神経免疫学会学術集会
  • Place of Presentation: 下関
• [Presentation] 免疫介在性神経疾患 (2013)
  • Author(s): 高橋幸利
  • Organizer: 第45回日本小児感染症学会総会・学術集会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] ビデオ講習：NMDAR 抗体脳炎 (2013)
  • Author(s): 高橋幸利
  • Organizer: 第25回 日本神経免疫学会学術集会
  • Place of Presentation: 下関
  • Invited
• [Presentation] シンポジウム「自己免疫性脳炎の診断と治療」-グルタミン酸受容体抗体の意義 (2012)
  • Author(s): 高橋幸利
  • Organizer: 第54回日本小児神経学会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 教育講演：自己免疫性介在性脳炎・脳症の診断・治療スキーム (2012)
  • Author(s): 高橋幸利
  • Organizer: 53回日本神経学会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 抗NMDAR脳炎の病態解明：抗体のシナプスNMDARによるCREBリン酸化への作用の検討 (2012)
  • Author(s): 高橋幸利、西村成子、高尾恵美子、笠井理沙、高久保瞳、福山哲広、井上有史
  • Organizer: 第24回日本神経免疫学会学術集会
  • Place of Presentation: 軽井沢
• [Presentation] Antibodies to GluR in epileptic encephalopathy including Rasmussen syndrome (2012)
  • Author(s): Yukitoshi Takahashi, Tetsuhiro Fukuyama
  • Organizer: 第46回日本てんかん学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Autoantibodies in epilepsy and limbic encephalitis (2012)
  • Author(s): Takahashi Y.
  • Organizer: 11th Asian and Oceanian Child Neurology Congress
  • Place of Presentation: Brisbane
  • Invited
• [Presentation] グルタミン酸受容体に対する自己免疫が介在する神経疾患の研究
  • Author(s): 高橋幸利
  • Organizer: 静岡県立大学薬学部大学院第229回月例薬学セミナー
  • Place of Presentation: 静岡
  • Invited
• [Presentation] 脳炎・脳症後のてんかんの特徴と自己抗体について
  • Author(s): 高橋幸利
  • Organizer: 第29回奈良小児てんかん研究会
  • Place of Presentation: 橿原
  • Invited
• [Book] プライマリ・ケアのための新規抗てんかん薬マスターブック (2012)
  • Author(s): 高橋幸利
  • Total Pages: 101
  • Publisher: 診断と治療社
• [Remarks] 「急性辺縁系脳炎等の自己免疫介在性脳炎・脳症」の診断スキーム -20130317-
  • URL: http://www.shizuokamind.org/wp-content/uploads/2012/03/scheme20130317.pdf
• [Remarks] 「急性辺縁系脳炎等の自己免疫介在性脳炎・脳症」の診断スキーム
  • URL: http://www.shizuokamind.org/images/stories/pdf/06-1-2-15.pdf
• [Remarks] 「急性辺縁系脳炎等の自己免疫介在性脳炎・脳症」の診断スキーム -20130317-
  • URL: http://www.shizuokamind.org/wp-content/uploads/2012/03/scheme20130317.pdf
• [Patent(Industrial Property Rights)] NMDA型グルタミン酸受容体抗体による不安モデルマウスの開発 (2014)
  • Inventor(s): 高橋幸利
  • Industrial Property Rights Holder: 財団法人ヒューマンサイエンス振興財団
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-174749
  • Filing Date: 2014-08-29
• [Patent(Industrial Property Rights)] プライマーセット及び免疫介在性てんかんの診断方法 (2014)
  • Inventor(s): 高橋幸利
  • Industrial Property Rights Holder: 財団法人ヒューマンサイエンス振興財団
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-221632
  • Filing Date: 2014-10-30
• [Patent(Industrial Property Rights)] NMDAR抗体IgGサブクラス測定法の開発 (2013)
  • Inventor(s): 高橋幸利、西村成子
  • Industrial Property Rights Holder: 財団法人ヒューマンサイエンス振興財団
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-211813
  • Filing Date: 2013-10-09
• [Patent(Industrial Property Rights)] 免疫介在性てんかんの診断マーカーとしてのPDCD1遺伝子情報 (2012)
  • Inventor(s): 高橋幸利
  • Industrial Property Rights Holder: 高橋幸利
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-159349
  • Filing Date: 2012-04-07