| Project/Area Number |
24591541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 慢性炎症 / 酸化ストレス / 移植免疫 / 血栓凝固 / GVHD / 造血幹細胞移植 / ＧＶＨＤ / トロンボモジュリン / 細胞誘電特性 |
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| Outline of Final Research Achievements |
With inflammatory reaction and progress of the oxidative stress, we observed the red blood cell rouleaux formation, decrease of band3, a dimer formation and fragmentation of PRDX2 sequentially in order by analyzing patient blood after the allogeneic hematopoietic stem cell transplantation (H-SCT). Because these were not detected in nephrotic syndrome, chronic active EBV infection and sepsis other than red blood cell rouleaux formation, it was thought that persistent chronic inflammation and oxidative stress occurred in GVHD after the transplant. In H-SCT, early coagulation disorder was associated with complications-related death, and the likelihood that a prognosis improved by early administration of thrombomodulin was shown. It was shown that thrombomodulin improved skin lesions of chronic GVHD in the mouse model. Based upon the foregoing, coagulation disorder, inflammation, and the oxidative stress are closely associated, and it is necessary to manage GVHD from these viewpoints.
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