| Project/Area Number |
24591544
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NEMOTO Atsushi 山梨大学, 総合研究部, 医学研究員
HIROSE Kinuko 山梨大学, 総合研究部, 医学研究員 (70436880)
KURODA Itaru 山梨大学, 総合研究部, 医学研究員 (30402051)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 白血病 / 造血幹細胞移植 / 移植片対白血病効果 / 細胞傷害因子 |
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| Outline of Final Research Achievements |
In allogeneic stem cell transplantation for advanced childhood acute lymphoblastic leukemia (ALL), it has been suggested that graft-versus-leukemia (GVL) effect eradicates residual disease. In GVL effect, cytotoxic ligands expressed on cytotoxic T-cells (CTLs) and NK cells play an essential role by inducing apoptosis of leukemia cells. In the present study, we confirmed that culture conditions mimicking bone marrow environment induce relative resistance of leukemia cells to chemotherapeutic agents. Of note, we also confirmed that TRAIL, one of cytotoxic ligands, is still active against leukemia cells in the culture conditions mimicking bone marrow environment. These observations suggested that allogeneic stem cell transplantation would be attractive therapeutic modalities against chemo-resistant childhood ALL.
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