| Project/Area Number |
24591545
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Gifu University |
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Principal Investigator |
KONDO naomi 岐阜大学, 医学(系)研究科(研究院), 名誉教授 (50124714)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Zenichiro 岐阜大学, 医学系研究科, 教授 (90303502)
MATSUI Eiko 岐阜大学, 医学部附属病院, 講師 (90334929)
KIMURA Takeshi 岐阜大学, 医学部附属病院, 助教 (60422705)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 体内時計遺伝子 / アレルギー関連遺伝子 / アレルギー発症 / 環境因子 / テーラーメイド医療 / 喘息 / 調節性T細胞 / インターフェロンγ |
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| Outline of Final Research Achievements |
The aim of this study is (1) analysis of relationship among allergic genes and biological clock genes and environments, and (2) establishment of an epoch-making prevention and treatment for allergic diseases.
As results, (1) expressions of biological clock genes (eq. CLOCK gene) were changeable during day and night, and production of interferon (IFN)-gannma that suppresses allergic reactions was suppressed by pH change. (2) The binding mode between interleukin (IL-18) and IL-18 receptor became clear, and then development of new medicines that are able to regulate IL-18 signaling was started for allergic diseases.
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