Identification and characterization of novel human hematopoietic stem cell populations using the micro-RNA sensor vector

Research Project

Project/Area Number	24591549
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Pediatrics
Research Institution	Kyoto University
Principal Investigator	HIRAMATSU Hidefumi 京都大学, 大学院医学研究科発達小児科学, 講師 (40362503)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	造血幹細胞 / マイクロRNA
Outline of Final Research Achievements	The characterization of human hematopoietic stem cells (HSCs) will facilitate the hematopoietic cell therapy such as bone marrow transplantation. Although the human HSCs have been identified by the expression of distinct surface markers, we have identified a microRNA, miR-126, is highly expressed and has an important role in human HSCs. We have developed a new system, which allows us to identify the cells with miR-126 expression and found a new population that might have a new hematopoietic stem cell activity. Further characterization of this population is under investigation.