| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Factor VIII (FVIII) is an important key factor on blood coagulation in the opposite conditions such as the hemorrhages and thrombi. However, there are still uncertain points on FVIII-based (anti-)coagulation and thrombus formation. The conventional researches of blood coagulation had been fully done separately by the intrinsic and extrinsic pathway, anti-coagulant pathway, and fibrinolytic pathway, but it is being now supported that all pathways simultaneously participate and progress in coagulation. In this study, we found the relationship of FVIII(a) with thrombin and FIXa (intrinsic factors), FVIIa/tissue factor (extrinsic factor), plasmin (fibrinolytic factor), protein S (anti-coagulant factor), neutrophil proteinase 3 (inflammatory factor) during the blood coagulation process.
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