Studies on the mechanisms of activation and inactivation of factor VIII: Applications of novel (anti-)coagulant therapy
Project/Area Number |
24591558
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
|
Research Institution | Nara Medical University |
Principal Investigator |
NOGAMI KEIJI 奈良県立医科大学, 医学部, 准教授 (50326328)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 血液凝固 / 第Ⅷ因子 / 蛋白相互作用 / 出血性疾患 / 第VIII因子 / 活性化/不活化 / 活性型第VII因子 / 組織因子 / トロンビン / 第IX因子 / 結合部位 / 炎症性因子 |
Outline of Final Research Achievements |
Factor VIII (FVIII) is an important key factor on blood coagulation in the opposite conditions such as the hemorrhages and thrombi. However, there are still uncertain points on FVIII-based (anti-)coagulation and thrombus formation. The conventional researches of blood coagulation had been fully done separately by the intrinsic and extrinsic pathway, anti-coagulant pathway, and fibrinolytic pathway, but it is being now supported that all pathways simultaneously participate and progress in coagulation. In this study, we found the relationship of FVIII(a) with thrombin and FIXa (intrinsic factors), FVIIa/tissue factor (extrinsic factor), plasmin (fibrinolytic factor), protein S (anti-coagulant factor), neutrophil proteinase 3 (inflammatory factor) during the blood coagulation process.
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Report
(4 results)
Research Products
(18 results)