Computational leukemic stem cell models in systems biology for analyses of cell kinetics in leukemic relapse and development of risk-stratified chemotherapy
Project/Area Number |
24591562
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
|
Research Institution | Kanazawa Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KOMATSUZAKI Toshihiko 金沢大学, 機械工学系, 准教授 (80293372)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 急性骨髄性白血病 / コンピューターシミュレーション / 白血病幹細胞 / システム生物学 / 微小残存病変 / コンピュータシミュレーション / 白血病治療モデル / 白血病造血モデル |
Outline of Final Research Achievements |
We have constructed a 3-dimentional computer simulation system to investigate the mechanisms of leukemic relapse and develop new risk-stratified treatment protocols. Comparing the cell kinetics of normal hemopoietic stem cells and leukemic stem cells, models of developing leukemias were successfully simulated from a single leukemic stem cells when the cell kinetics of leukemic stem cells was more than 3 times slower than normal hematopoietic stem cells. Subsequently, introducing simulations of chemotherapy, adapted from the AML-05 protocol from Japan Pediatric Leukemia Lymphoma Study Group, into our leukemic models has established a treatment model with 10-year relapse-free survival as a prototype.
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Report
(4 results)
Research Products
(4 results)