Development for a treatment of chronic granulomatous disease

• Project/Area Number: 24591563
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kawasaki Medical School
• Principal Investigator: KURIBAYASHI Futoshi 川崎医科大学, 医学部, 教授 (60251443)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 好中球 / 活性酸素 / 慢性肉芽腫症 / NADPHオキシダーゼ / CGD / 好酸球

Outline of Final Research Achievements

The gaol of this research is a presentaion of a basic scientific results concerning Chronic Granulomatous Disease (CGD) together wiht an analysis of transcription, post-transcription and the modulation of mRNA. This research clarified a new type of CGD (J Clin. Immunol.2015) and revealed a rare type of female CGD (Chest 2015).

Research Products

• [Journal Article] Monocyte/macrophage-Specific NADPH Oxidase Contributes to Antimicrobial Host Defense in X-CGD (2015)
  • Author(s): Yuka Okura, Masafumi Yamada, Futoshi Kuribayashi, Ichiro Kobayashi, and Tadashi Ariga
  • Journal Title: J Clin. Immunol. Volume: 35 Issue: 2 Pages: 158-167
  • DOI: 10.1007/s10875-015-0138-4
  • NAID: 120005702353
  • Peer Reviewed / Open Access
• [Journal Article] A 60-Year-Old Asymptomatic Woman With Pulmonary Lesions and Cervical Lymphadenopathy Woman With Pulmonary Lesions and Lymphadenopathy Tomoko Yamagishi, Nobuaki Ochi, Hiromichi Yamane, Futoshi Kuribayashi, and Nagio Takigawa (2015)
  • Author(s): Tomoko Yamagishi, Nobuaki Ochi, Hiromichi Yamane, Futoshi Kuribayashi, and Nagio Takigawa
  • Journal Title: Chest Volume: 147 Issue: 2 Pages: e48-e51
  • DOI: 10.1378/chest.14-1215
  • Peer Reviewed / Open Access
• [Journal Article] The histone acetyltransferase p300/CBP-associated factor acts as an effective suppressor of secretory immunoglobulin synthesis in immature B cells (2015)
  • Author(s): Hidehiko Kikuchi, Masami Nakayama, Chikage Kawai, Futoshi Kuribayashi, Hitomi Mimuro, Shinobu Imajoh-Ohmi, Nishitoh H, Yasunari Takami, and Tatsuo Nakayama
  • Journal Title: Microbiol. Immunol Volume: 59 Issue: 4 Pages: 243-247
  • DOI: 10.1111/1348-0421.12237
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] GCN5 is essential for IRF-4 gene expression followed by transcriptional activation of Blimp-1 in immature B cells. (2014)
  • Author(s): Kikuchi H, Nakayama M, Kuribayashi F, Imajoh-Ohmi S, Nishitoh H, Takami Y, Nakayama T.
  • Journal Title: J Leukoc Biol Volume: 95 Issue: 3 Pages: 399-404
  • DOI: 10.1189/jlb.0413232
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients. (2014)
  • Author(s): Akira Yamauchi, Mikako Degawa-Yamauchi, Futoshi Kuribayashi, Shiro Kanegasaki, and Tomoko Tsuchiya
  • Journal Title: Journal of Immunological Methods Volume: 404 Pages: 59-70
  • DOI: 10.1016/j.jim.2013.12.005
  • Peer Reviewed
• [Journal Article] Down-regulation of Fas-mediated apoptosis by plasma transglutaminase factor XIII that catalyzes fetal-specific cross-link of the Fas molecule. (2014)
  • Author(s): Kikuchi H, Kuribayashi F, Imajoh-Ohmi S.
  • Journal Title: Biochem Biophys Res Commun. Volume: 443 Issue: 1 Pages: 13-17
  • DOI: 10.1016/j.bbrc.2013.10.163
  • Peer Reviewed
• [Journal Article] GCN5 protects vertebrate cells against UV-irradiation via controlling gene expression of DNA polymerase n. (2012)
  • Author(s): Kikuchi H., et al.
  • Journal Title: J. Biol. Chem. Volume: 287 Issue: 47 Pages: 39842-39849
  • DOI: 10.1074/jbc.m112.406389
  • Peer Reviewed
• [Journal Article] The phagocyte NADPH oxidase and bacterial infections (2012)
  • Author(s): Akira YAMAUCHI, Akitoyo ICHINOSE, Chikage KAWAI, and Futoshi KURIBAYASHI
  • Journal Title: Kawasaki Medical Journal Volume: 38(1) Pages: 11-18
  • NAID: 110009393934
  • Peer Reviewed
• [Journal Article] A dual reporter splicing assay using HaloTag-containing proteins. Curr Chem Genomics. (2012)
  • Author(s): Oshima K, Nagase T, Imai K, Nonoyama S, Obara M, Mizukami T, Nunoi H, Kanegane H, Kuribayashi F, Amemiya S, Ohara O.
  • Journal Title: Curr Chem Genomics. Volume: 6 Issue: 1 Pages: 27-37
  • DOI: 10.2174/1875397301206010027
  • Peer Reviewed
• [Journal Article] EBF1 acts as a powerful repressor of Blimp-1 gene expression in immature B cells. (2012)
  • Author(s): Hidehiko Kikuchi, Masami Nakayama, Yasunari Takami, Futoshi Kuribayashi, Tatsuo Nakayama
  • Journal Title: Biochem Biophys Res Commun. Volume: 422(4) Issue: 4 Pages: 780-785
  • DOI: 10.1016/j.bbrc.2012.05.099
  • Peer Reviewed
• [Presentation] マウス妊娠初期における胎仔・胎盤のトリプトファン分解活性のstrainによる差異について (2014)
  • Author(s): 大山 文男, 栗林 太, 刀祢 重信
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-11-27
• [Presentation] 膵がん転移を抑えるための基礎的検討 (2014)
  • Author(s): 山内 明、山村 真弘、山口佳之、栗林 太
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-11-25
• [Presentation] 核の凝縮機構の解析ー無細胞アポトーシス系を用いて (2014)
  • Author(s): 刀祢 重信, 杉本 憲治, 網代 廣三, 佐久間 哲史, 山本 卓, 栗林 太
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-11-25
• [Presentation] 成人女性に無症候性の肺アスペルギルス症として発症した慢性肉芽腫症の1例 (2013)
  • Author(s): 山岸智子，越智宣昭，山根弘路，瀧川奈義夫
  • Organizer: 第109回日本内科学会中国地方会例会次第
  • Place of Presentation: 岡山コンベンションセンター（岡山市）
• [Presentation] 多形核白血球細胞のアクチン分解と好中球機能変化 (2013)
  • Author(s): 大本 純子, 栗林太, 中村 三千男, 大海 忍
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] GCN5 is involved in regulation of immunoglobulin heavy chain gene expression in immature B cells (2013)
  • Author(s): Hidehiko Kikuchi, Masami Nakayama, Futoshi Kuribayashi, Shinobu Imajoh-Ohmi, Hideki Nishitoh, Yasunari Takami, Tatsuo Nakayama
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] GCN5ファミリーによるタンパク質リン酸化のエピジェネティック制御機構の 解析および発癌・癌悪性化への関与の検討 (2013)
  • Author(s): 栗林太
  • Organizer: 東京大学医科学研究所共同研究拠点成果報告会
  • Place of Presentation: （東京）
  • Invited
• [Presentation] Robust directionality in neutrophil chemotaxis toward the end-target chemoattractant fMLP: an optical approach to the mechanism. (2012)
  • Author(s): Akira Yamauchi, Shiro Kanegasaki, and Futoshi Kuribayashi
  • Organizer: International Endotoxin and Innate Immunity Society Meeting 2012 (IEIIS2012) and the 2nd Homeostatic Inflammation Symposium (HIS2012)
  • Place of Presentation: 学士会館（東京）
• [Presentation] マウス妊娠初期におけるトリプトファン分解活性はIDOではなくTDO由来である (2012)
  • Author(s): 大山文男，金井 将昭，中村 敏一，船越 洋，栗林太，刀祢重信
  • Organizer: 第３５回日本分子生物学会
  • Place of Presentation: マリンメッセ福岡（福岡市）
• [Presentation] エラスターゼによる多形核白血球アクチンの特異的切断と好中球機能について (2012)
  • Author(s): 大本 純子, 栗林 太, 中村 三千男, 大海 忍
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: マリンメッセ福岡（福岡市）
• [Presentation] Possible involvement of Helios in controlling the immature B cell functions via transcriptional regulation of protein kinase Cs (2012)
  • Author(s): Hidehiko Kikuchi, Masami Nakayama, Yasunari Takami, Futoshi Kuribayashi, Tatsuo Nakayama
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: マリンメッセ福岡（福岡市）