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Exploration for therapeutic target using a novel prognostic factor IKZF1 targeting cells in childhood acute lymphoblastic leukemia

Research Project

Project/Area Number 24591568
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionNational Hospital Organization Nagoya Medical Center

Principal Investigator

HATTORI Hiroyoshi  独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, その他 (20624513)

Co-Investigator(Kenkyū-buntansha) HORIBE Keizo  独立行政法人国立病院機構名古屋医療センター, 臨床研究センター, 臨床研究センター長 (30209308)
Research Collaborator SAITO Yuko  
YAMASHITA Yuka  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords小児急性リンパ性白血病 / 抗がん剤感受性 / 予後因子 / BCP-ALLモデル細胞
Outline of Final Research Achievements

Patients with childhood acute lymphoblastic leukemia (ALL) in high risk recur about 30%. Recently, IKZF1 alteration in genomic DNA has been found as a prognostic factor. To elucidate the role of the IKZF1 alteration, we developed childhood ALL model cells with IKZF1 mutations. We investigated the relationship between the IKZF1 alteration and anti-cancer drug sensitivity which are frequently used in childhood ALL. The results showed the sensitivity to the several drugs may be dependent on the IKZF1 alteration.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (1 results)

  • [Journal Article] Dynamic Modulation of Thymidylate Synthase Gene Expression and Fluorouracil Sensitivity in Human Colorectal Cancer Cells.2015

    • Author(s)
      Wakasa K, Kawabata R, Nakao S, Hattori H, Taguchi K, Uchida J, Yamanaka T, Maehara Y, Fukushima M, Oda S.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 4 Pages: e0123076-e0123076

    • DOI

      10.1371/journal.pone.0123076

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NF-kB signaling mediates acquired resistance after PARP inhibition.2015

    • Author(s)
      Nakagawa Y, Sedukhina AS, Okamoto N, Nagasawa S, Suzuki N, Ohta T, Hattori H, Roche-Molina M, Narváez AJ, Jeyasekharan AD, Bernal JA, Sato K.
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 3825-39

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response.2014

    • Author(s)
      Hattori H, Janky R, Nietfeld W, Aerts S, Babu MM, Venkitaraman AR.
    • Journal Title

      Cell Cycle

      Volume: 13 Issue: 16 Pages: 2572-86

    • DOI

      10.4161/15384101.2015.942209

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nilotinib monotherapy induced complete remission in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to imatinib and dasatinib.2013

    • Author(s)
      Sekimizu M, Yamashita Y, Ueki H, Akita N, Hattori H, Maeda N, Horibe K.
    • Journal Title

      Leuk Lymphoma

      Volume: Epub ahead of print Pages: 1-2

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.2013

    • Author(s)
      Jeyasekharan AD, Liu Y, Hattori H, Pisupati V, Jonsdottir AB, Rajendra E, Lee M, Sundaramoorthy E, Schlachter S, Kaminski CF, Ofir-Rosenfeld Y, Sato K, Savill J, Ayoub N, Venkitaraman AR.
    • Journal Title

      Nat Struct Mol Biol.

      Volume: 20 Issue: 10 Pages: 1191-8

    • DOI

      10.1038/nsmb.2666

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei.2013

    • Author(s)
      Mahen R, Hattori H, Lee M, Sharma P, Jeyasekharan AD, Venkitaraman AR.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 5 Pages: e61893-e61893

    • DOI

      10.1371/journal.pone.0061893

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair2012

    • Author(s)
      Sato K, Sundaramoorthy E, Rajendra E, Hattori H, Jeyasekharan AD, Ayoub N, Schiess R, Aebersold R, Nishikawa H, Sedukhina AS, Wada H, Ohta T, Venkitaraman AR
    • Journal Title

      Curr Biol

      Volume: 22 Issue: 18 Pages: 1659-66

    • DOI

      10.1016/j.cub.2012.07.034

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Clinical Issues for the Treatment of Adolescents and Young Adults with Hematologic Malignancy and Bone and Soft Tissue Sarcoma in Japan – A Single Institute’s Experience2015

    • Author(s)
      Hattori Hiroyoshi
    • Organizer
      9th St. Jude-VIVA Forum in Pediatric Oncology
    • Place of Presentation
      Singapore
    • Year and Date
      2015-03-28 – 2015-03-29
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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