Risk of new lethal arrhythmia in School-based Electrocardiographic Screening Programs
| Project/Area Number |
24591570
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Niigata University |
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Principal Investigator |
Suzuki Hiroshi 新潟大学, 医歯学総合病院, 特任教授 (00401737)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHINA Satoshi 新潟大学, 医歯学総合病院, 助教 (80444165)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 学校心臓検診 / 致死性不整脈 / 若年突然死 / 致死的不整脈 / 学校心臓病検診 |
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| Outline of Final Research Achievements |
Short QT Syndrome (SQTS) is characterized by a short QT interval (QTI) and is a cause of sudden death at premature age. QTI were measured in 13948 subjects 12-13 years old in a school-based ECG screening program. 30 subjects with QTI below the 0.25th percentile of the total subjects, were enrolled. We conducted further examination. The mean follow-up period was 2.1 years. 12 of 30 met the SQTS diagnostic criterion proposed in 2013. 5 subjects had a family history of premature sudden death. One was observed with ventricular tachycardia. 3 had an episode of syncope during follow-up period. Among them, one was diagnosed with epilepsy, while the others were diagnosed with neurally mediated syncope. 7 of 12 who met the SQTS diagnostic criterion were observed with normal QTI during follow-up period. Genetic analysis for SQTS genes, did not show any mutations in two subjects. The criteria might overdiagnose SQTS in adolescent population.
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Report
(5 results)
Research Products
(13 results)
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[Journal Article] Electrical storm in patients with brugada syndrome is associated with early repolarization.2014
Author(s)
Kaneko Y, Horie M, Niwano S, Kusano KF, Takatsuki S, Kurita T, Mitsuhashi T, Nakajima T, Irie T, Hasegawa K, Noda T, Kamakura S, Aizawa Y, Yasuoka R, Torigoe K Suzuki H, Ohe T, Shimizu A, Fukuda K, Kurabayashi M, Aizawa Y.
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Journal Title
Circ Arrhythm Electrophysiol.
Volume: 6
Issue: 6
Pages: 1122-8
DOI
Related Report
Peer Reviewed / Open Access
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