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Study on the comprehensive treatment strategy of hemophagocytic syndrome

Research Project

Project/Area Number 24591577
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionYamaguchi University (2013-2014)
Kyushu University (2012)

Principal Investigator

OHGA Shouichi  山口大学, 医学(系)研究科(研究院), 教授 (60233053)

Co-Investigator(Kenkyū-buntansha) TANAKA Tamami  九州大学, 医学研究院, 学術研究員 (60423547)
Co-Investigator(Renkei-kenkyūsha) IMADOME Ken-ichi  国立成育医療センター研究所, 母児感染研究部・感染防御研究室, 室長 (70392488)
OHSHIMA Koichi  久留米大学医学部, 第2病理学教室, 教授 (50203766)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords血球貪食症候群 / EBウイルス / リンパ増殖性疾患 / 造血細胞移植 / 免疫化学療法 / 抗サイトカイン療法
Outline of Final Research Achievements

We studied the comprehensive treatment strategy of inherited or secondary hemophagocytic syndrome (hemophagocytic lymphohistiocytosis: HLH). In patients with inherited HLH, the utility and critical issues of unrelated donor umbilical cord blood transplantation (UCBT) as the curative therapy were reported. On the other hand, the early non-cytotoxic immunomodulation therapy was verified to be curable for patients with severe secondary HLH including Epstein-Barr virus (EBV)- associated HLH and neonatal herpes simplex virus (HSV)-associated HLH. Targeted cells of infection should be determined to exclude the underlying primary immunodeficiency diseases especially for the curative treatment of EBV-associated lymphoproliferative disease.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (61 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (21 results) (of which Peer Reviewed: 20 results,  Open Access: 7 results,  Acknowledgement Compliant: 5 results) Presentation (34 results) (of which Invited: 13 results) Book (6 results)

  • [Journal Article] Takotsubo (stress) cardiomyopathy and obstructive renal stones in an infant with norovirus gastroenteritis2015

    • Author(s)
      Okada S, Azuma Y, Kaneyasu H, Mizutani M, Korenaga Y, Kittaka S, Suzuki1 Y, Ohnishi1 Y, Furuta T, Ohga S
    • Journal Title

      Int J Cardiol

      Volume: 186 Pages: 233-5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Successful treatment of corticosteroid with antiviral therapy for a neonatal liver failure with disseminated herpes simplex virus infection2015

    • Author(s)
      Maeba S, Hasegawa S, Shimomura M, Ichimura T, Takahashi K, Motoyama M, Fukunaga S, Ito Y, Ichiyama T, Ohga S
    • Journal Title

      Am J Perinatol

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drug reaction with eosinophilia and systemic symptoms during primary Epstein-Barr virus infection2015

    • Author(s)
      Nanishi E, Hoshina T, Ohga S, Nishio H, Hara T
    • Journal Title

      Drug reaction with eosinophilia and systemic symptoms during primary Epstein-Barr virus infection

      Volume: 48 Issue: 1 Pages: 109-12

    • DOI

      10.1016/j.jmii.2014.06.012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children: report from the Japan HLH/LCH Study Group2014

    • Author(s)
      Kogawa K, Sato H, Asano T, Ohga S, Kudo K, Morimoto A, Ohta S, Wakiguchi H, Kanegane H, Oda M, Ishii E
    • Journal Title

      Pediatr Blood Cancer

      Volume: 61 Issue: 7 Pages: 1257-62

    • DOI

      10.1002/pbc.24980

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Acute pericardial effusion representing the TNF-α-mediated severe inflammation but not the coronary artery outcome of Kawasaki disease2014

    • Author(s)
      Okada S, Hasegawa S, Suzuki Y, Matsubara T, Shimomura M, Okuda M, Ichiyama T,Ohga S
    • Journal Title

      Scand J Rheumatol

      Volume: Oct.29 Pages: 1-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Survival and neurodevelopmental outcome of preterm infants born at 22-24 weeks of gestational age.2014

    • Author(s)
      Ochiai M, Kinjo T, Takahata Y, Iwayama M, Abe T, Ihara K, Ohga S, Fukushima K, Kato K, Taguchi T, Hara T
    • Journal Title

      Neonatology

      Volume: 10 Issue: 2 Pages: 79-84

    • DOI

      10.1159/000355818

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early progression of atherosclerosis in children with chronic infantile neurological cutaneous and articular syndrome2014

    • Author(s)
      Yamamura K, Takada H, Uike K, Nakashima Y, Hirata Y, Nagata H, Takimoto T, Ishimura M, Morihana E, Ohga S, Hara T
    • Journal Title

      Rheumatology

      Volume: 53 Issue: 10 Pages: 1783-1787

    • DOI

      10.1093/rheumatology/keu180

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Successful treatment of non-Hodgkin's lymphoma using R-CHOP in a patient with Wiskott-Aldrich syndrome followed by a reduced-intensity stem cell transplant.2014

    • Author(s)
      Yuhki Koga, Hidetoshi Takada, Aiko Suminoe, Shouichi Ohga, Toshiro Hara
    • Journal Title

      Pediatric Transplantation

      Volume: VOL.18 Issue: 6

    • DOI

      10.1111/petr.12297

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] EBウイルス 研究史 ~感染細胞、病態と疾患の関わりから~2014

    • Author(s)
      大賀正一
    • Journal Title

      ウイルス (日本ウイルス学会誌)

      Volume: 64 Pages: 67-74

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リンパ増殖性疾患 ~Epstein-Barrウイルスの関与する遺伝性素因~2014

    • Author(s)
      大賀正一
    • Journal Title

      臨床血液 (日本血液学会誌)

      Volume: 55 Pages: 2221-4

    • NAID

      130004696117

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility of reduced-intensity conditioning followed by unrelated cord blood transplantation for primary hemophagocytic lymphohistiocytosis: a nationwide retrospective analysis in Japan2013

    • Author(s)
      Sawada A, Ohga S, Ishii E, Inoue M, Okada K, Inagaki J, Goto H, Suzuki N, Koike K, Atsuta Y, Suzuki R, Yabe H, Kawa K, Kato K, Yasutomo K
    • Journal Title

      Int J Hematol

      Volume: 98(2) Issue: 2 Pages: 223-230

    • DOI

      10.1007/s12185-013-1391-z

    • NAID

      10031194738

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics and outcomes of Chédiak-Higashi syndrome: a nationwide survey of Japan.2013

    • Author(s)
      Nagai K, Yasukawa M, et al.
    • Journal Title

      Pediatr Blood Cancer

      Volume: 60 Issue: 10 Pages: 1582-1586

    • DOI

      10.1002/pbc.24637

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A non-invasive diagnosis of histiocytic necrotizing lymphadenitis by means of gene expression profile analysis of peripheral blood mononuclear cells2013

    • Author(s)
      Ishimura M, Yamamoto H, Mizuno Y, Takada H, Goto M, Doi T, Hoshina T, Ohga S, Ohshima K, Hara T
    • Journal Title

      J Clin Immunol

      Volume: 33(5) Issue: 5 Pages: 1018-26

    • DOI

      10.1007/s10875-013-9897-y

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants2013

    • Author(s)
      Inoue H, Ohga S, Kusuda T, Kitajima J, Kinjo T, Ochiai M, Takahata Y, Honjo S, Hara T
    • Journal Title

      Early Hum Dev

      Volume: 89(6) Issue: 6 Pages: 425-429

    • DOI

      10.1016/j.earlhumdev.2012.12.011

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neonatal hemophagocytic lymphohistiocytosis associated with a vertical transmission of coxsackievirus B12013

    • Author(s)
      Fukazawa M, Hoshina T, Nanishi E, Nishio H, Doi T, Ohga S, Hara T
    • Journal Title

      J Infect Chemother

      Volume: 19(6) Issue: 6 Pages: 1210-1213

    • DOI

      10.1007/s10156-013-0629-2

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 特集 血球貪食症候群の病態と診療の新展開 血球貪食症候群に対する治療2013

    • Author(s)
      大賀 正一
    • Journal Title

      血液フロンティア

      Volume: 23巻1号 Pages: 69-75

    • Related Report
      2013 Research-status Report
  • [Journal Article] Reduced-intensity conditioning in unrelated donor cord blood transplantation for familial hemophagocytic lymphohistiocytosis2012

    • Author(s)
      Nishi M, Nishimura R, Suzuki N, Sawada A, Okamura T, Fujita N, Kanai R, Yano J, Adachi S, Yasumi T, Sato E, Yasutomo K, Ishii E, Ohga S
    • Journal Title

      Am J Hematol

      Volume: 87(6):637-9 Issue: 6 Pages: 637-639

    • DOI

      10.1002/ajh.23190

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute liver failure as the initial manifestation of Wilson disease trigerred by human parvovirus B19 infection2012

    • Author(s)
      Shiraishi A, Hoshina T, Ihara K, Doi T, Ohga S, Hara T
    • Journal Title

      Pediatr Infect Dis J

      Volume: 31(1) Issue: 1 Pages: 103-104

    • DOI

      10.1097/inf.0b013e31823662ee

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children : a nationwide survey in Japan2011

    • Author(s)
      Asano T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudo K, Ohta S, Wakiguchi H, Tabuchi K, Kato S, Ishii E
    • Journal Title

      Pediatr Blood Cancer

      Volume: (in press) Issue: 1 Pages: 110-114

    • DOI

      10.1002/pbc.23384

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Treatment choice of immunotherapy or further chemotherapy for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis2011

    • Author(s)
      Shiraishi A, Ohga S, Doi T, Ishimura M, Takimoto T, Takada H, Miyamoto T, Abe Y, Hara T
    • Journal Title

      Pediatr Blood Cancer

      Volume: (in press) Issue: 2 Pages: 265-270

    • DOI

      10.1002/pbc.24039

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential transmission and postnatal outcome in triplets with congenital cytomegalovirus infection2011

    • Author(s)
      Kitajima J, Inoue H, Ohga S, Kinjo T, Ochiai M, Yoshida T, Kusuhara K, Hara T
    • Journal Title

      Pediatr Development Pathol

      Volume: (in press) Issue: 2 Pages: 151-155

    • DOI

      10.2350/11-05-1034-cr.1

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Siblings with atypical HUS experienced in our hospital2014

    • Author(s)
      Shimomura M, Ichimura T, Kittaka S, Mizutani M, Hasegawa S, Ohga S
    • Organizer
      Pediatric aHUS forum in Yamaguchi 2014
    • Place of Presentation
      ANAクラウンプラザホテル 宇部
    • Year and Date
      2014-12-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] リンパ増殖性疾患~Epstein-Barrウイルスの関与する遺伝性素因~2014

    • Author(s)
      大賀正一
    • Organizer
      第76回 日本血液学会学術集会 教育講演
    • Place of Presentation
      国際会議場 大阪
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 小児の造血および免疫不全症~EBウイルスが関与する免疫異常~2014

    • Author(s)
      大賀正一
    • Organizer
      第16回 京阪こどもカンファレンス
    • Place of Presentation
      関西医科大学 大阪
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] An Early and Non-invasive Diagnostic Method for Histiocytic Necrotizing Lymphadenitis2014

    • Author(s)
      Ishimura M. Mizuno Y, Takada H, Ohga S, Hara T
    • Organizer
      The 25th Fukuoka International Symposium on Pediatric / Maternal-Child Health Research (FISP/M)
    • Place of Presentation
      九州大学 福岡
    • Year and Date
      2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] EBウイルス感染症に伴う難治性疾患2014

    • Author(s)
      大賀正一
    • Organizer
      第124回山口県小児科医会・山口地方会 合同特別講演
    • Place of Presentation
      ANAクラウンプラザホテル 宇部
    • Year and Date
      2014-07-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 意識障害と広範な大脳白質病変を呈した家族性血球貪食症候群III型の15歳女児例2014

    • Author(s)
      赤峰哲、黒川麻里、大場詩子、石村匡崇、瀧本智仁、石崎義人、古賀友紀、酒井康成、鳥巣浩幸、住江愛子、高田英俊、大賀正一、原寿郎
    • Organizer
      第56回日本小児神経学会学術集会
    • Place of Presentation
      アクトシティ浜松 浜松
    • Year and Date
      2014-05-28 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 発症時に肝不全を呈した家族性血球貪食性リンパ組織球症(FHL)の2例2014

    • Author(s)
      赤峰哲、加藤稚子、瀧本智仁、石村匡崇、保科隆之、高田英俊、大賀正一、林田真、田口智章、原寿郎
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      国際会議場 名古屋
    • Year and Date
      2014-04-11 – 2014-04-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 悪性リンパ腫を疑った、遅発性家族性血球貪食性リンパ組織球症3型の1例2014

    • Author(s)
      小野宏彰、瀧本智仁、古賀友紀、石村匡崇、大場詩子、住江愛子、高田英俊、大賀正一、八角高裕、原寿郎
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      国際会議場 名古屋
    • Year and Date
      2014-04-11 – 2014-04-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] EBウイルス感染症によって誘発された薬疹を認めた2症例2014

    • Author(s)
      名西悦郎、西尾壽乘、保科隆之、大賀正一、原寿郎
    • Organizer
      第23回EBウイルス感染症研究会
    • Place of Presentation
      東京 東京ステーションコンファレンス605
    • Related Report
      2013 Research-status Report
  • [Presentation] Salvage treatment of refractory LCH and HLH2013

    • Author(s)
      Ohga S (invited)
    • Organizer
      The 54th Meeting of Korean Society of Hematology, Korea Histiocytosis Working Party Symposium
    • Place of Presentation
      Changwon, Korea
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Treatment choice of immunotherapy or further chemotherapy for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis2013

    • Author(s)
      Shiraishi A, Ohga S, Doi T, Ishimura M, Takimoto T, Takada H, Miyamoto T, Abe Y, Hara T
    • Organizer
      The 24th Fukuoka International Symposium on Pediatric / Maternal-Child Health Research (FISP/M)
    • Place of Presentation
      Fukuoka, Japan 九州大学コラボステーションI
    • Related Report
      2013 Research-status Report
  • [Presentation] Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants2013

    • Author(s)
      Inoue H, Ohga S, Kusuda T, Kitajima J, Kinjo T, Ochiai M, Takahata Y, Honjo S, Hara T
    • Organizer
      The 24th Fukuoka International Symposium on Pediatric / Maternal-Child Health Research (FISP/M)
    • Place of Presentation
      Fukuoka, Japan 九州大学コラボステーションI
    • Related Report
      2013 Research-status Report
  • [Presentation] Early progression of atherosclerosis in children with cryopyrin-associated periodic syndrome2013

    • Author(s)
      Yamamura K, Uike K, Nakashima Y, Hirata Y, Nagata H, Takimoto T, Ishimura M, Takada H, Ohga S, Hara T
    • Organizer
      The 9th Asian Society for Pediatric Research & 20th Perinatal Society of Malaysia Annual Congress
    • Place of Presentation
      Sarawak, Malaysia
    • Related Report
      2013 Research-status Report
  • [Presentation] 若年性骨髄単球性白血病(JMML)と類似したWiskott-Aldrich症候群(WAS)の2症例2013

    • Author(s)
      大園秀一、野口磨依子、中川慎一郎、上田耕一郎、稲田浩子、大賀正一、笹原洋二、小島勢二
    • Organizer
      第19回九州山口小児血液・腫瘍研究会
    • Place of Presentation
      福岡 九州大学病院
    • Related Report
      2013 Research-status Report
  • [Presentation] 発症時に肝不全を呈した家族性血球貪食症候群(FHL)2型の2例2013

    • Author(s)
      加藤稚子、赤峰 哲、瀧本智仁、石村匡崇、高田英俊、保科隆之、大賀正一、原 寿郎、江角元史郎、林田真、田口智章
    • Organizer
      第475回日本小児科学会福岡地方会
    • Place of Presentation
      福岡 福岡大学メディカルホール
    • Related Report
      2013 Research-status Report
  • [Presentation] 大学病院における最近10年間の感染症死亡例の検討2013

    • Author(s)
      戸田尚子、保科隆之、山村健一郎、落合正行、鳥巣浩幸、住江愛子、高田英俊、大賀正一、原 寿郎
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島 広島市文化交流会館
    • Related Report
      2013 Research-status Report
  • [Presentation] 難治性EBウイルス感染症 ~EBV-HLHとCAEBVの病態から治療まで~ Overview.2012

    • Author(s)
      大賀 正一
    • Organizer
      第44回日本小児感染症学会
    • Place of Presentation
      小倉
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 造血不全症:感染症治療のポイント.2012

    • Author(s)
      大賀 正一
    • Organizer
      第54回日本小児血液がん学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Differential transmission and postnatal outcomes in triplets with congenital cytomegalovirus infection2012

    • Author(s)
      Kitajima J, Inoue H, Ohga S, Kinjo T, Ochiai M, Yoshida T, Kusuhara K, Hara T.
    • Organizer
      The 8th Asian Society for Pediatric Research.
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Research-status Report
  • [Presentation] An early and non-invasive diagnostic method for histiocytic necrotizing lymphadenitis2012

    • Author(s)
      Ishimura M, Mizuno Y, Takada H, Goto M, Doi T, Hoshina T, Ohga S, Hara T
    • Organizer
      The 8th Asian Society for Pediatric Research.
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Research-status Report
  • [Presentation] Treatment outcomes of Epstein Barr virus-associated hemophagocytic lymphohistiocytosis in a single institution2012

    • Author(s)
      Shiraishi A, Ohga S, Doi T, Ishimura M, Takimoto T, Takada H, Miyamoto T, Abe Y, Hara T.
    • Organizer
      The 8th Asian Society for Pediatric Research.
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Research-status Report
  • [Presentation] コクサッキーウイルスB1の垂直感染により全身感染症を発症し、血球貪食症候群を合併した新生児例2012

    • Author(s)
      深澤光晴、名西悦郎、西尾壽乗、保科隆之、土居岳彦、大賀正一、原 寿郎
    • Organizer
      第44回日本小児感染症学会
    • Place of Presentation
      小倉
    • Related Report
      2012 Research-status Report
  • [Presentation] Clinical features of 8 adult patients with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis2012

    • Author(s)
      Shiratsuchi M, Ohno H, Nakashima Y, Ikeda M, Honda E, Matsushima T, Ohga S, Abe Y, Takayanagi R
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] インターフェロン遺伝子発現上昇は壊死性リンパ節炎症(菊池病)の診断に有用である2012

    • Author(s)
      石村匡崇、水野由美、高田英俊、後藤元宏、土居岳彦、保科隆之、大賀正一、大島孝一、原 寿郎
    • Organizer
      第40回日本臨床免疫学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] コクサッキーウイルスB1の垂直感染により前進感染症を発症し、血球貪食性リンパ組織球症を合併した新生児例2012

    • Author(s)
      名西悦郎、西尾壽乘、保科隆之、土居岳彦、大賀正一、原 寿郎
    • Organizer
      第86回日本感染症学会
    • Place of Presentation
      長崎
    • Related Report
      2012 Research-status Report
  • [Presentation] インターフェロン誘導遺伝子発現上昇は壊死性リンパ節炎(菊池病)の診断に有用である2012

    • Author(s)
      石村匡崇、水野由美、高田英俊、後藤元宏、土居岳彦、保科隆之、大賀正一、原 寿郎
    • Organizer
      第115 回日本小児科学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 家族性血球貪食性リンパ組織球症(FHL)に対する前処置軽減非血縁臍帯血移植(RIC-UCBT)2012

    • Author(s)
      西 眞範、西村良成、鈴木信寛、岡村隆行、矢野 潤、足立壮一、八角高裕、佐藤恵実子、金井理恵、藤田直人、澤田明久、石井榮一、大賀正一
    • Organizer
      第115 回日本小児科学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] EBウイルス感染に伴う難治性疾患.

    • Author(s)
      大賀 正一
    • Organizer
      第27回九州免疫血液研究会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 感染症と造血・免疫不全症 ~免疫制御か、造血細胞移植か?~

    • Author(s)
      大賀 正一
    • Organizer
      北海道小児感染症セミナー
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 咽頭炎からはじまる難治性感染症 ~EBウイルスを中心に~.

    • Author(s)
      大賀 正一
    • Organizer
      岩国・柳井地区耳鼻科医会&小児科医会
    • Place of Presentation
      岩国
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 血球貪食症候群の病態と治療

    • Author(s)
      大賀 正一
    • Organizer
      第19回 奈良県血液研究会
    • Place of Presentation
      奈良
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 免疫・造血不全症と感染症.

    • Author(s)
      大賀 正一
    • Organizer
      第74回日本血液学会コーポレートセミナー
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 移植後リンパ増殖症 ~EBウイルス関連を中心に~

    • Author(s)
      .大賀 正一
    • Organizer
      第25回日本小腸移植研究会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] EBウイルス感染によるリンパ増殖症.

    • Author(s)
      大賀 正一
    • Organizer
      第16回中国地区小児免疫薬物療法研究会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] Ⅵ.感染症 36. EBウイルス感染症 小児疾患診療のための病態生理1 改訂5版2014

    • Author(s)
      脇口宏之、大賀正一
    • Total Pages
      1128
    • Publisher
      東京医学社
    • Related Report
      2014 Annual Research Report
  • [Book] ウイルス関連血球貪食症候群(VAHS) 日本臨床別冊「感染症症候群(下)臓器別感染症編」2013

    • Author(s)
      石村 匡崇、大賀 正一
    • Publisher
      日本臨牀社
    • Related Report
      2013 Research-status Report
  • [Book] 新生児鉄過剰症2013

    • Author(s)
      北島 順子、大賀 正一
    • Publisher
      日本臨牀社
    • Related Report
      2012 Research-status Report
  • [Book] 血液フロンティア2013

    • Author(s)
      大賀 正一
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Research-status Report
  • [Book] 小児の発熱 A to Z-診断・治療のTipsとPitfalls- 52.慢性活動性EBウイルス感染症(CAEBV)2012

    • Author(s)
      大賀 正一
    • Publisher
      診断と治療社
    • Related Report
      2012 Research-status Report
  • [Book] 特集 知っておきたい内科症候群 血球貪食症候群 hemophoagocytic syndrome (HPS)2012

    • Author(s)
      大賀 正一
    • Publisher
      南江堂
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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