Study on the comprehensive treatment strategy of hemophagocytic syndrome

• Project/Area Number: 24591577
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Yamaguchi University (2013-2014); Kyushu University (2012)
• Principal Investigator: OHGA Shouichi 山口大学, 医学(系)研究科(研究院), 教授 (60233053)
• Co-Investigator(Kenkyū-buntansha): TANAKA Tamami 九州大学, 医学研究院, 学術研究員 (60423547)
• Co-Investigator(Renkei-kenkyūsha): IMADOME Ken-ichi 国立成育医療センター研究所, 母児感染研究部・感染防御研究室, 室長 (70392488) ; OHSHIMA Koichi 久留米大学医学部, 第2病理学教室, 教授 (50203766)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 血球貪食症候群 / ＥＢウイルス / リンパ増殖性疾患 / 造血細胞移植 / 免疫化学療法 / 抗サイトカイン療法

Outline of Final Research Achievements

We studied the comprehensive treatment strategy of inherited or secondary hemophagocytic syndrome (hemophagocytic lymphohistiocytosis: HLH). In patients with inherited HLH, the utility and critical issues of unrelated donor umbilical cord blood transplantation (UCBT) as the curative therapy were reported. On the other hand, the early non-cytotoxic immunomodulation therapy was verified to be curable for patients with severe secondary HLH including Epstein-Barr virus (EBV)- associated HLH and neonatal herpes simplex virus (HSV)-associated HLH. Targeted cells of infection should be determined to exclude the underlying primary immunodeficiency diseases especially for the curative treatment of EBV-associated lymphoproliferative disease.

Research Products

• [Journal Article] Takotsubo (stress) cardiomyopathy and obstructive renal stones in an infant with norovirus gastroenteritis (2015)
  • Author(s): Okada S, Azuma Y, Kaneyasu H, Mizutani M, Korenaga Y, Kittaka S, Suzuki1 Y, Ohnishi1 Y, Furuta T, Ohga S
  • Journal Title: Int J Cardiol Volume: 186 Pages: 233-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Successful treatment of corticosteroid with antiviral therapy for a neonatal liver failure with disseminated herpes simplex virus infection (2015)
  • Author(s): Maeba S, Hasegawa S, Shimomura M, Ichimura T, Takahashi K, Motoyama M, Fukunaga S, Ito Y, Ichiyama T, Ohga S
  • Journal Title: Am J Perinatol Volume: in press
  • Peer Reviewed
• [Journal Article] Drug reaction with eosinophilia and systemic symptoms during primary Epstein-Barr virus infection (2015)
  • Author(s): Nanishi E, Hoshina T, Ohga S, Nishio H, Hara T
  • Journal Title: Drug reaction with eosinophilia and systemic symptoms during primary Epstein-Barr virus infection Volume: 48 Issue: 1 Pages: 109-12
  • DOI: 10.1016/j.jmii.2014.06.012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children: report from the Japan HLH/LCH Study Group (2014)
  • Author(s): Kogawa K, Sato H, Asano T, Ohga S, Kudo K, Morimoto A, Ohta S, Wakiguchi H, Kanegane H, Oda M, Ishii E
  • Journal Title: Pediatr Blood Cancer Volume: 61 Issue: 7 Pages: 1257-62
  • DOI: 10.1002/pbc.24980
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Acute pericardial effusion representing the TNF-α-mediated severe inflammation but not the coronary artery outcome of Kawasaki disease (2014)
  • Author(s): Okada S, Hasegawa S, Suzuki Y, Matsubara T, Shimomura M, Okuda M, Ichiyama T,Ohga S
  • Journal Title: Scand J Rheumatol Volume: Oct.29 Pages: 1-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Survival and neurodevelopmental outcome of preterm infants born at 22-24 weeks of gestational age. (2014)
  • Author(s): Ochiai M, Kinjo T, Takahata Y, Iwayama M, Abe T, Ihara K, Ohga S, Fukushima K, Kato K, Taguchi T, Hara T
  • Journal Title: Neonatology Volume: 10 Issue: 2 Pages: 79-84
  • DOI: 10.1159/000355818
  • Peer Reviewed / Open Access
• [Journal Article] Early progression of atherosclerosis in children with chronic infantile neurological cutaneous and articular syndrome (2014)
  • Author(s): Yamamura K, Takada H, Uike K, Nakashima Y, Hirata Y, Nagata H, Takimoto T, Ishimura M, Morihana E, Ohga S, Hara T
  • Journal Title: Rheumatology Volume: 53 Issue: 10 Pages: 1783-1787
  • DOI: 10.1093/rheumatology/keu180
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Successful treatment of non-Hodgkin's lymphoma using R-CHOP in a patient with Wiskott-Aldrich syndrome followed by a reduced-intensity stem cell transplant. (2014)
  • Author(s): Yuhki Koga, Hidetoshi Takada, Aiko Suminoe, Shouichi Ohga, Toshiro Hara
  • Journal Title: Pediatric Transplantation Volume: VOL.18 Issue: 6
  • DOI: 10.1111/petr.12297
  • Peer Reviewed / Open Access
• [Journal Article] EBウイルス 研究史 ～感染細胞、病態と疾患の関わりから～ (2014)
  • Author(s): 大賀正一
  • Journal Title: ウイルス （日本ウイルス学会誌） Volume: 64 Pages: 67-74
  • Peer Reviewed
• [Journal Article] リンパ増殖性疾患 ～Epstein-Barrウイルスの関与する遺伝性素因～ (2014)
  • Author(s): 大賀正一
  • Journal Title: 臨床血液 （日本血液学会誌） Volume: 55 Pages: 2221-4
  • NAID: 130004696117
  • Peer Reviewed / Open Access
• [Journal Article] Feasibility of reduced-intensity conditioning followed by unrelated cord blood transplantation for primary hemophagocytic lymphohistiocytosis: a nationwide retrospective analysis in Japan (2013)
  • Author(s): Sawada A, Ohga S, Ishii E, Inoue M, Okada K, Inagaki J, Goto H, Suzuki N, Koike K, Atsuta Y, Suzuki R, Yabe H, Kawa K, Kato K, Yasutomo K
  • Journal Title: Int J Hematol Volume: 98(2) Issue: 2 Pages: 223-230
  • DOI: 10.1007/s12185-013-1391-z
  • NAID: 10031194738
  • Peer Reviewed
• [Journal Article] Clinical characteristics and outcomes of Chédiak-Higashi syndrome: a nationwide survey of Japan. (2013)
  • Author(s): Nagai K, Yasukawa M, et al.
  • Journal Title: Pediatr Blood Cancer Volume: 60 Issue: 10 Pages: 1582-1586
  • DOI: 10.1002/pbc.24637
  • Peer Reviewed
• [Journal Article] A non-invasive diagnosis of histiocytic necrotizing lymphadenitis by means of gene expression profile analysis of peripheral blood mononuclear cells (2013)
  • Author(s): Ishimura M, Yamamoto H, Mizuno Y, Takada H, Goto M, Doi T, Hoshina T, Ohga S, Ohshima K, Hara T
  • Journal Title: J Clin Immunol Volume: 33(5) Issue: 5 Pages: 1018-26
  • DOI: 10.1007/s10875-013-9897-y
  • Peer Reviewed
• [Journal Article] Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants (2013)
  • Author(s): Inoue H, Ohga S, Kusuda T, Kitajima J, Kinjo T, Ochiai M, Takahata Y, Honjo S, Hara T
  • Journal Title: Early Hum Dev Volume: 89(6) Issue: 6 Pages: 425-429
  • DOI: 10.1016/j.earlhumdev.2012.12.011
  • Peer Reviewed
• [Journal Article] Neonatal hemophagocytic lymphohistiocytosis associated with a vertical transmission of coxsackievirus B1 (2013)
  • Author(s): Fukazawa M, Hoshina T, Nanishi E, Nishio H, Doi T, Ohga S, Hara T
  • Journal Title: J Infect Chemother Volume: 19(6) Issue: 6 Pages: 1210-1213
  • DOI: 10.1007/s10156-013-0629-2
  • Peer Reviewed
• [Journal Article] 特集 血球貪食症候群の病態と診療の新展開 血球貪食症候群に対する治療 (2013)
  • Author(s): 大賀 正一
  • Journal Title: 血液フロンティア Volume: 23巻1号 Pages: 69-75
• [Journal Article] Reduced-intensity conditioning in unrelated donor cord blood transplantation for familial hemophagocytic lymphohistiocytosis (2012)
  • Author(s): Nishi M, Nishimura R, Suzuki N, Sawada A, Okamura T, Fujita N, Kanai R, Yano J, Adachi S, Yasumi T, Sato E, Yasutomo K, Ishii E, Ohga S
  • Journal Title: Am J Hematol Volume: 87(6):637-9 Issue: 6 Pages: 637-639
  • DOI: 10.1002/ajh.23190
  • Peer Reviewed
• [Journal Article] Acute liver failure as the initial manifestation of Wilson disease trigerred by human parvovirus B19 infection (2012)
  • Author(s): Shiraishi A, Hoshina T, Ihara K, Doi T, Ohga S, Hara T
  • Journal Title: Pediatr Infect Dis J Volume: 31(1) Issue: 1 Pages: 103-104
  • DOI: 10.1097/inf.0b013e31823662ee
  • Peer Reviewed
• [Journal Article] Hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children : a nationwide survey in Japan (2011)
  • Author(s): Asano T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudo K, Ohta S, Wakiguchi H, Tabuchi K, Kato S, Ishii E
  • Journal Title: Pediatr Blood Cancer Volume: (in press) Issue: 1 Pages: 110-114
  • DOI: 10.1002/pbc.23384
  • Peer Reviewed
• [Journal Article] Treatment choice of immunotherapy or further chemotherapy for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (2011)
  • Author(s): Shiraishi A, Ohga S, Doi T, Ishimura M, Takimoto T, Takada H, Miyamoto T, Abe Y, Hara T
  • Journal Title: Pediatr Blood Cancer Volume: (in press) Issue: 2 Pages: 265-270
  • DOI: 10.1002/pbc.24039
  • Peer Reviewed
• [Journal Article] Differential transmission and postnatal outcome in triplets with congenital cytomegalovirus infection (2011)
  • Author(s): Kitajima J, Inoue H, Ohga S, Kinjo T, Ochiai M, Yoshida T, Kusuhara K, Hara T
  • Journal Title: Pediatr Development Pathol Volume: (in press) Issue: 2 Pages: 151-155
  • DOI: 10.2350/11-05-1034-cr.1
  • Peer Reviewed
• [Presentation] Siblings with atypical HUS experienced in our hospital (2014)
  • Author(s): Shimomura M, Ichimura T, Kittaka S, Mizutani M, Hasegawa S, Ohga S
  • Organizer: Pediatric aHUS forum in Yamaguchi 2014
  • Place of Presentation: ANAｸﾗｳﾝﾌﾟﾗｻﾞﾎﾃﾙ 宇部
  • Year and Date: 2014-12-03
• [Presentation] リンパ増殖性疾患～Epstein-Barrウイルスの関与する遺伝性素因～ (2014)
  • Author(s): 大賀正一
  • Organizer: 第76回 日本血液学会学術集会 教育講演
  • Place of Presentation: 国際会議場 大阪
  • Year and Date: 2014-10-31
  • Invited
• [Presentation] 小児の造血および免疫不全症～EBｳｲﾙｽが関与する免疫異常～ (2014)
  • Author(s): 大賀正一
  • Organizer: 第16回 京阪こどもカンファレンス
  • Place of Presentation: 関西医科大学 大阪
  • Year and Date: 2014-10-11
  • Invited
• [Presentation] An Early and Non-invasive Diagnostic Method for Histiocytic Necrotizing Lymphadenitis (2014)
  • Author(s): Ishimura M. Mizuno Y, Takada H, Ohga S, Hara T
  • Organizer: The 25th Fukuoka International Symposium on Pediatric / Maternal-Child Health Research (FISP/M)
  • Place of Presentation: 九州大学 福岡
  • Year and Date: 2014-08-30
• [Presentation] EBウイルス感染症に伴う難治性疾患 (2014)
  • Author(s): 大賀正一
  • Organizer: 第124回山口県小児科医会・山口地方会 合同特別講演
  • Place of Presentation: ANAｸﾗｳﾝﾌﾟﾗｻﾞﾎﾃﾙ 宇部
  • Year and Date: 2014-07-13
  • Invited
• [Presentation] 意識障害と広範な大脳白質病変を呈した家族性血球貪食症候群III型の15歳女児例 (2014)
  • Author(s): 赤峰哲、黒川麻里、大場詩子、石村匡崇、瀧本智仁、石崎義人、古賀友紀、酒井康成、鳥巣浩幸、住江愛子、高田英俊、大賀正一、原寿郎
  • Organizer: 第56回日本小児神経学会学術集会
  • Place of Presentation: ｱｸﾄｼﾃｨ浜松 浜松
  • Year and Date: 2014-05-28 – 2014-05-31
• [Presentation] 発症時に肝不全を呈した家族性血球貪食性リンパ組織球症（FHL）の2例 (2014)
  • Author(s): 赤峰哲、加藤稚子、瀧本智仁、石村匡崇、保科隆之、高田英俊、大賀正一、林田真、田口智章、原寿郎
  • Organizer: 第117回日本小児科学会学術集会
  • Place of Presentation: 国際会議場 名古屋
  • Year and Date: 2014-04-11 – 2014-04-13
• [Presentation] 悪性リンパ腫を疑った、遅発性家族性血球貪食性リンパ組織球症3型の1例 (2014)
  • Author(s): 小野宏彰、瀧本智仁、古賀友紀、石村匡崇、大場詩子、住江愛子、高田英俊、大賀正一、八角高裕、原寿郎
  • Organizer: 第117回日本小児科学会学術集会
  • Place of Presentation: 国際会議場 名古屋
  • Year and Date: 2014-04-11 – 2014-04-13
• [Presentation] EBウイルス感染症によって誘発された薬疹を認めた2症例 (2014)
  • Author(s): 名西悦郎、西尾壽乘、保科隆之、大賀正一、原寿郎
  • Organizer: 第23回EBウイルス感染症研究会
  • Place of Presentation: 東京 東京ステーションコンファレンス605
• [Presentation] Salvage treatment of refractory LCH and HLH (2013)
  • Author(s): Ohga S (invited)
  • Organizer: The 54th Meeting of Korean Society of Hematology, Korea Histiocytosis Working Party Symposium
  • Place of Presentation: Changwon, Korea
  • Invited
• [Presentation] Treatment choice of immunotherapy or further chemotherapy for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (2013)
  • Author(s): Shiraishi A, Ohga S, Doi T, Ishimura M, Takimoto T, Takada H, Miyamoto T, Abe Y, Hara T
  • Organizer: The 24th Fukuoka International Symposium on Pediatric / Maternal-Child Health Research (FISP/M)
  • Place of Presentation: Fukuoka, Japan 九州大学コラボステーションI
• [Presentation] Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants (2013)
  • Author(s): Inoue H, Ohga S, Kusuda T, Kitajima J, Kinjo T, Ochiai M, Takahata Y, Honjo S, Hara T
  • Organizer: The 24th Fukuoka International Symposium on Pediatric / Maternal-Child Health Research (FISP/M)
  • Place of Presentation: Fukuoka, Japan 九州大学コラボステーションI
• [Presentation] Early progression of atherosclerosis in children with cryopyrin-associated periodic syndrome (2013)
  • Author(s): Yamamura K, Uike K, Nakashima Y, Hirata Y, Nagata H, Takimoto T, Ishimura M, Takada H, Ohga S, Hara T
  • Organizer: The 9th Asian Society for Pediatric Research & 20th Perinatal Society of Malaysia Annual Congress
  • Place of Presentation: Sarawak, Malaysia
• [Presentation] 若年性骨髄単球性白血病（JMML）と類似したWiskott-Aldrich症候群（WAS）の2症例 (2013)
  • Author(s): 大園秀一、野口磨依子、中川慎一郎、上田耕一郎、稲田浩子、大賀正一、笹原洋二、小島勢二
  • Organizer: 第19回九州山口小児血液・腫瘍研究会
  • Place of Presentation: 福岡 九州大学病院
• [Presentation] 発症時に肝不全を呈した家族性血球貪食症候群（FHL）2型の2例 (2013)
  • Author(s): 加藤稚子、赤峰 哲、瀧本智仁、石村匡崇、高田英俊、保科隆之、大賀正一、原 寿郎、江角元史郎、林田真、田口智章
  • Organizer: 第475回日本小児科学会福岡地方会
  • Place of Presentation: 福岡 福岡大学メディカルホール
• [Presentation] 大学病院における最近10年間の感染症死亡例の検討 (2013)
  • Author(s): 戸田尚子、保科隆之、山村健一郎、落合正行、鳥巣浩幸、住江愛子、高田英俊、大賀正一、原 寿郎
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 広島 広島市文化交流会館
• [Presentation] 難治性EBウイルス感染症 ～EBV-HLHとCAEBVの病態から治療まで～ Overview. (2012)
  • Author(s): 大賀 正一
  • Organizer: 第44回日本小児感染症学会
  • Place of Presentation: 小倉
  • Invited
• [Presentation] 造血不全症：感染症治療のポイント. (2012)
  • Author(s): 大賀 正一
  • Organizer: 第54回日本小児血液がん学会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Differential transmission and postnatal outcomes in triplets with congenital cytomegalovirus infection (2012)
  • Author(s): Kitajima J, Inoue H, Ohga S, Kinjo T, Ochiai M, Yoshida T, Kusuhara K, Hara T.
  • Organizer: The 8th Asian Society for Pediatric Research.
  • Place of Presentation: Seoul, Korea
• [Presentation] An early and non-invasive diagnostic method for histiocytic necrotizing lymphadenitis (2012)
  • Author(s): Ishimura M, Mizuno Y, Takada H, Goto M, Doi T, Hoshina T, Ohga S, Hara T
  • Organizer: The 8th Asian Society for Pediatric Research.
  • Place of Presentation: Seoul, Korea
• [Presentation] Treatment outcomes of Epstein Barr virus-associated hemophagocytic lymphohistiocytosis in a single institution (2012)
  • Author(s): Shiraishi A, Ohga S, Doi T, Ishimura M, Takimoto T, Takada H, Miyamoto T, Abe Y, Hara T.
  • Organizer: The 8th Asian Society for Pediatric Research.
  • Place of Presentation: Seoul, Korea
• [Presentation] コクサッキーウイルスB1の垂直感染により全身感染症を発症し、血球貪食症候群を合併した新生児例 (2012)
  • Author(s): 深澤光晴、名西悦郎、西尾壽乗、保科隆之、土居岳彦、大賀正一、原 寿郎
  • Organizer: 第44回日本小児感染症学会
  • Place of Presentation: 小倉
• [Presentation] Clinical features of 8 adult patients with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (2012)
  • Author(s): Shiratsuchi M, Ohno H, Nakashima Y, Ikeda M, Honda E, Matsushima T, Ohga S, Abe Y, Takayanagi R
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] インターフェロン遺伝子発現上昇は壊死性リンパ節炎症（菊池病）の診断に有用である (2012)
  • Author(s): 石村匡崇、水野由美、高田英俊、後藤元宏、土居岳彦、保科隆之、大賀正一、大島孝一、原 寿郎
  • Organizer: 第40回日本臨床免疫学会
  • Place of Presentation: 東京
• [Presentation] コクサッキーウイルスB1の垂直感染により前進感染症を発症し、血球貪食性リンパ組織球症を合併した新生児例 (2012)
  • Author(s): 名西悦郎、西尾壽乘、保科隆之、土居岳彦、大賀正一、原 寿郎
  • Organizer: 第86回日本感染症学会
  • Place of Presentation: 長崎
• [Presentation] インターフェロン誘導遺伝子発現上昇は壊死性リンパ節炎（菊池病）の診断に有用である (2012)
  • Author(s): 石村匡崇、水野由美、高田英俊、後藤元宏、土居岳彦、保科隆之、大賀正一、原 寿郎
  • Organizer: 第115 回日本小児科学会
  • Place of Presentation: 福岡
• [Presentation] 家族性血球貪食性リンパ組織球症（FHL）に対する前処置軽減非血縁臍帯血移植（RIC-UCBT） (2012)
  • Author(s): 西 眞範、西村良成、鈴木信寛、岡村隆行、矢野 潤、足立壮一、八角高裕、佐藤恵実子、金井理恵、藤田直人、澤田明久、石井榮一、大賀正一
  • Organizer: 第115 回日本小児科学会
  • Place of Presentation: 福岡
• [Presentation] EBウイルス感染に伴う難治性疾患.
  • Author(s): 大賀 正一
  • Organizer: 第27回九州免疫血液研究会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 感染症と造血・免疫不全症 ～免疫制御か、造血細胞移植か？～
  • Author(s): 大賀 正一
  • Organizer: 北海道小児感染症セミナー
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 咽頭炎からはじまる難治性感染症 ～EBウイルスを中心に～.
  • Author(s): 大賀 正一
  • Organizer: 岩国・柳井地区耳鼻科医会＆小児科医会
  • Place of Presentation: 岩国
  • Invited
• [Presentation] 血球貪食症候群の病態と治療
  • Author(s): 大賀 正一
  • Organizer: 第19回 奈良県血液研究会
  • Place of Presentation: 奈良
  • Invited
• [Presentation] 免疫・造血不全症と感染症.
  • Author(s): 大賀 正一
  • Organizer: 第74回日本血液学会コーポレートセミナー
  • Place of Presentation: 京都
  • Invited
• [Presentation] 移植後リンパ増殖症 ～EBウイルス関連を中心に～
  • Author(s): .大賀 正一
  • Organizer: 第25回日本小腸移植研究会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] EBウイルス感染によるリンパ増殖症.
  • Author(s): 大賀 正一
  • Organizer: 第16回中国地区小児免疫薬物療法研究会
  • Place of Presentation: 広島
  • Invited
• [Book] Ⅵ．感染症 36. EBウイルス感染症 小児疾患診療のための病態生理1 改訂5版 (2014)
  • Author(s): 脇口宏之、大賀正一
  • Total Pages: 1128
  • Publisher: 東京医学社
• [Book] ウイルス関連血球貪食症候群（VAHS） 日本臨床別冊「感染症症候群（下）臓器別感染症編」 (2013)
  • Author(s): 石村 匡崇、大賀 正一
  • Publisher: 日本臨牀社
• [Book] 新生児鉄過剰症 (2013)
  • Author(s): 北島 順子、大賀 正一
  • Publisher: 日本臨牀社
• [Book] 血液フロンティア (2013)
  • Author(s): 大賀 正一
  • Publisher: 医薬ジャーナル社
• [Book] 小児の発熱 A to Z－診断・治療のTipsとPitfalls－ 52.慢性活動性EBウイルス感染症（CAEBV） (2012)
  • Author(s): 大賀 正一
  • Publisher: 診断と治療社
• [Book] 特集 知っておきたい内科症候群 血球貪食症候群 hemophoagocytic syndrome (HPS) (2012)
  • Author(s): 大賀 正一
  • Publisher: 南江堂