| Project/Area Number |
24591577
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Yamaguchi University (2013-2014)
Kyushu University (2012) |
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Principal Investigator |
OHGA Shouichi 山口大学, 医学(系)研究科(研究院), 教授 (60233053)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Tamami 九州大学, 医学研究院, 学術研究員 (60423547)
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| Co-Investigator(Renkei-kenkyūsha) |
IMADOME Ken-ichi 国立成育医療センター研究所, 母児感染研究部・感染防御研究室, 室長 (70392488)
OHSHIMA Koichi 久留米大学医学部, 第2病理学教室, 教授 (50203766)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 血球貪食症候群 / ＥＢウイルス / リンパ増殖性疾患 / 造血細胞移植 / 免疫化学療法 / 抗サイトカイン療法 |
|---|
| Outline of Final Research Achievements |
We studied the comprehensive treatment strategy of inherited or secondary hemophagocytic syndrome (hemophagocytic lymphohistiocytosis: HLH). In patients with inherited HLH, the utility and critical issues of unrelated donor umbilical cord blood transplantation (UCBT) as the curative therapy were reported. On the other hand, the early non-cytotoxic immunomodulation therapy was verified to be curable for patients with severe secondary HLH including Epstein-Barr virus (EBV)- associated HLH and neonatal herpes simplex virus (HSV)-associated HLH. Targeted cells of infection should be determined to exclude the underlying primary immunodeficiency diseases especially for the curative treatment of EBV-associated lymphoproliferative disease.
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