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Resistance Values in the Limbs, as measured by a Multiple-frequency Bioelectrical-impedance Method, are Useful for Estimating the Severity of Kawasaki Disease.

Research Project

Project/Area Number 24591578
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionKagoshima University

Principal Investigator

YUICHI Nomura  鹿児島大学, 医歯(薬)学総合研究科, 准教授 (90237884)

Co-Investigator(Kenkyū-buntansha) EGUCHI Taisuke  鹿児島大学, 医学部歯学部附属病院, 助教 (20535687)
NISHI Junichiro  鹿児島大学, 大学院医歯学総合研究科, 教授 (40295241)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords川崎病 / 硬性浮腫 / インピーダンス / 重症度評価 / 重症度 / 免疫グロブリン大量療法 / 治療抵抗性 / 免疫グロブリン反応性
Outline of Final Research Achievements

We evaluated the efficacy of resistance values in Kawasaki disease (KD) patients for estimating the severity of KD. Patients and Methods: In 57 patients with the acute phase of KD (before intravenous immunoglobulin; IVIG), 36 with the sub-acute phase, 54 controls, and 23 febrile control, we measured resistance (impedance; IMP) in each child’s total body and extremities using MLT-550N. Corrected IMP values (coIMP; IMP x limb’s cross-sectional area/ limb’s length) were also examined. Results: Percentages of extra-cellular water in KD patients are higher than controls. IMP values were not different among patients with KD and controls. CoIMP values in the forearm or lower leg of patients in the acute phase of KD were higher than those of controls. The values of coIMP of IVIG non-responders at the acute phase were higher than those of responders. Conclusion: Values of co-IMP might be useful for estimating the severity of KD.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (24 results)

All 2015 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 3 results) Presentation (16 results)

  • [Journal Article] Immunoglobulin G values before treatment are correlated with the responsiveness to initial intravenous immunoglobulin therapy for Kawasaki disease.2014

    • Author(s)
      Yanagimoto K, Nomura Y, Masuda K, Hirabayashi M, Morita Y, Yoshishige M, Ueno K, Eguchi T, Kawano Y.
    • Journal Title

      International Archives of Allergy and Immunology

      Volume: 164 Issue: 2 Pages: 83-88

    • DOI

      10.1159/000363383

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 免疫グロブリン大量療法への反応が予測される川崎病患児における不応例の検討.2014

    • Author(s)
      川村順平,野村裕一,益田君教,森田康子,吉重道子,柳元孝介,上野健太郎,江口太助,河野嘉文.
    • Journal Title

      日本小児循環器学会雑誌

      Volume: 30 Pages: 298-302

    • NAID

      130004879027

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 川崎病の診断基準を満たした若年性特発性関節炎の1例-インターロイキン18値測定の有用性-.2014

    • Author(s)
      江口郁,野村裕一,久保田知洋,山遠剛,井之上寿美,丸山慎介,西川拓朗,和田昭宏,河野嘉文,武井修治.
    • Journal Title

      小児科臨床

      Volume: 67 Pages: 1173-1176

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electrocardiographic Screening of 1-Month-Old Infants for Identifying Prolonged QT Intervals.2013

    • Author(s)
      Masao Yoshinaga, Hiroya Ushinohama, Seiichi Sato, Nobuo Tauchi, Hitoshi Horigome, Hideto, Takahashi, Naokata Sumitomo, Yuu Kucho, Hirohiko Shiraishi, Yuichi Nomura, Wataru Shimizu and Masami Nagashima.
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 6 Pages: 932-938

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 鹿児島市学校心臓検診における川崎病問診票の有用性.2013

    • Author(s)
      野村裕一、益田君教、江口太助、西順一郎、田中裕治、西畠信、吉永正夫、河野嘉文.
    • Journal Title

      小児科臨床

      Volume: 66(1) Pages: 71-77

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum procalcitonin value is useful for predicting severity of Kawasaki disease.2012

    • Author(s)
      Hideki Yoshikawa, Yuichi Nomura, Kiminori Masuda, Chihaya Koriyama, Michiko Arata, Daisuke Hazeki, Kosuke Yanagimoto, Kentaro Ueno, Taisuke Eguchi, Yoshifumi Kawano.
    • Journal Title

      Pedatr Infect Dis J

      Volume: 31(5) Issue: 5 Pages: 523-525

    • DOI

      10.1097/inf.0b013e3182463879

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of immunoglobulin plus predonisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial2012

    • Author(s)
      Kobayashi T, Saji T, Otani T, Takeuchi K, Nakamura T, Arakawa H, Kato T, Hara T, Hamaoka K, Ogawa S,et al.
    • Journal Title

      Lancet

      Volume: 379 Issue: 9826 Pages: 1613-1620

    • DOI

      10.1016/s0140-6736(11)61930-2

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 体重25kg以上の川崎病患児の検討.2012

    • Author(s)
      柳元孝介、野村裕一、益田君教、荒田道子、櫨木大祐、上野健太郎、江口太助、島子敦史.
    • Journal Title

      日児循誌

      Volume: 28(3) Pages: 174-178

    • NAID

      10031121937

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Resistance Values in the Limbs are Useful for Estimating the Severity of Kawasaki Disease.2015

    • Author(s)
      Nomura Y, Masuda K, Morita Y, Ninomiya Y, Ueno K, Eguchi T, Kawano Y
    • Organizer
      Eleventh International Kawasaki Disease Symposium.
    • Place of Presentation
      Honolulu, United States
    • Year and Date
      2015-02-03 – 2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Circulating platelet-neutrophil aggregates play a significant role in Kawasaki disease.2015

    • Author(s)
      Ueno K, Nomura Y, Morita Y, Eguchi T, Masuda K, Kawano Y.
    • Organizer
      Eleventh International Kawasaki Disease Symposium.
    • Place of Presentation
      Honolulu, United States
    • Year and Date
      2015-02-03 – 2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 川崎病患児における四肢インピーダンス値の検討.2014

    • Author(s)
      野村裕一,益田君教,森田康子,二宮由美子,上野健太郎,江口太助,河野嘉文.
    • Organizer
      第34回日本川崎病学会・学術集会
    • Place of Presentation
      東京 (学術総合センター)
    • Year and Date
      2014-10-31 – 2014-11-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 左冠動脈巨大瘤の血栓性閉塞による虚血性心筋症をきたした自閉症の6歳女児例.2014

    • Author(s)
      小川結実,棈松貴成,宮園明典,二宮由美子,上野健太郎,江口太助,野村裕一,河野 嘉文.
    • Organizer
      第34回日本川崎病学会・学術集会
    • Place of Presentation
      東京 (学術総合センター)
    • Year and Date
      2014-10-31 – 2014-11-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 川崎病血管炎における血小板好中球複合体の関与の検討.2014

    • Author(s)
      上野健太郎,二宮由美子,柳元孝介,江口太助,野村裕一,河野嘉文,中江広治,森田康子,益田君教.
    • Organizer
      第50回日本小児循環器学会総会・学術集会
    • Place of Presentation
      岡山(岡山コンベンションセンター)
    • Year and Date
      2014-07-03 – 2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] In vitro analysis of the mechanisms of intravenous immunoglobulin and prednisolone for the prevention of coronary artery abnormalities in Kawasaki disease.2014

    • Author(s)
      Ueno K, Kawaminami K, Miyahara E, Morita Y, Ninomiya Y, Yanagimoto K, Eguchi T, Masuda K, Nomura Y, Kawano Y.
    • Organizer
      48th Annual Meeting of the Association for European Paediatric and Congenital Cardiology
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Steroid Significantly Reduces Immunoglobulin Therapy Resistance in High Risk Kawasaki Disease Patients with Elevated BNP: A Sub analysis of RAISE Study.2014

    • Author(s)
      Fukazawa R, Abe M, Kobayashi T, Saji T, Hamaoka K, Ichida F, Katoh T, Miura M, Nomura Y, Seki M, Fuse S, Ogawa S
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Immunoglobulin G value before treatment is correlated with the responsiveness to initial intravenous immunoglobulin therapy for Kawasaki Disease.2013

    • Author(s)
      Yanagimoto K, Nomura Y, Masuda K, Hirabayashi M, Morita Y, Arata M, Ueno K, Eguchi T, Kawano Y.
    • Organizer
      47th annual meeting of the association for European pediatric cardiology
    • Place of Presentation
      London, UK
    • Related Report
      2013 Research-status Report
  • [Presentation] 川崎病冠動脈後遺症発症に関与する内皮細胞増殖とアポトーシスの不均衡2013

    • Author(s)
      上野健太郎,中江広治,柳元孝介,江口太助,野村裕一,森田康子,荒田道子,益田君教
    • Organizer
      第49回日本小児循環器学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 内径のZスコアによる川崎病冠動脈瘤の重症度の評価‐当院での予備データと多施設共同研究計画‐2013

    • Author(s)
      福島直哉,三浦 大,小林 徹,布施茂登,佐地 勉,山岸敬幸,加藤太一,野村裕一,濱岡建城,深澤隆治,賀藤 均,須田憲治,脇 研自
    • Organizer
      第33回日本川崎病学会・学術集会
    • Place of Presentation
      富山
    • Related Report
      2013 Research-status Report
  • [Presentation] 重症川崎病での血中BNP上昇の意義(RAISE studyサブ解析).2013

    • Author(s)
      阿倍正徳,深澤隆治,佐地 勉,小林 徹,濱岡建城,原 寿郎,荒川浩一,加藤太一,三浦 大,小川俊一,野村裕一,布施茂登,市田蕗子,鮎沢 衛,関 満,森川昭博.
    • Organizer
      第33回日本川崎病学会・学術集会
    • Place of Presentation
      富山
    • Related Report
      2013 Research-status Report
  • [Presentation] 鹿児島県における川崎病治療の変化.2013

    • Author(s)
      江口太助,上野健太郎,吉重道子,益田君教,二宮由美子,徳永正朝,荒武真司,今村真理,野村裕一,河野嘉文.
    • Organizer
      第33回日本川崎病学会・学術集会
    • Place of Presentation
      富山
    • Related Report
      2013 Research-status Report
  • [Presentation] 川崎病の診断をみたした若年性特発性関節炎の1例2013

    • Author(s)
      江口 郁,久保田知洋,山遠 剛,上野健太郎,井之上寿美,和田昭宏,江口太助,野村裕一,河野嘉文,武井修治.
    • Organizer
      第33回日本川崎病学会・学術集会
    • Place of Presentation
      富山
    • Related Report
      2013 Research-status Report
  • [Presentation] Characteristics of patients with Kawasaki disease who showed nonresponsiveness for initial intravenous immunoglobulin treatment among patients predicted as being low risk for a nonresponder.2013

    • Author(s)
      Junpei Kawamura, Yuichi Nomura, Kiminori Masuda, Yasuko Morita, Michiko Arata, Daisuke Hazeki,1) Kosuke Yanagimoto,Kentaro Ueno, Taisuke Eguchi, Yoshifumi Kawano.
    • Organizer
      アジア太平洋心臓病会議
    • Place of Presentation
      パタヤ(タイ)
    • Related Report
      2012 Research-status Report
  • [Presentation] Gunmaスコア低値例における免疫グロブリン大量療法不応例の特徴2012

    • Author(s)
      野村裕一、益田君教、川村順平、荒田道子、柳元孝介、上野健太郎、江口太助.
    • Organizer
      小児循環器学会総会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 川崎病患児治療前免疫グロブリンG値の免疫グロブリン大量療法反応性についての関与2012

    • Author(s)
      柳元孝介、中江広治、川村順平、森田康子、上野健太郎、荒田道子、江口太助、益田君教、野村裕一.
    • Organizer
      日本川崎病学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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