Investigation of pediatric mucosal immune system and pathogenesis of pediatric onset gastrointestinal diseases.
| Project/Area Number |
24591585
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Toshiaki 順天堂大学, 医学部, 教授 (30260889)
SUZUKI Ryuyo 順天堂大学, 医学部, 准教授 (70420859)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 食物アレルギー / 新生児・乳児消化管アレルギー / 炎症性腸疾患 / クローン病 / 潰瘍性大腸炎 / リンパ濾胞 / CXCL13 / 粘膜免疫 / 経口免疫寛容 / 消化管アレルギー / リンパ濾胞増殖症 / 好酸球性胃腸症 / 炎症性シグナル分子 / CXCR-3関連分子 / CCL11 / CXCL9 |
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| Outline of Final Research Achievements |
To investigate the pathogenesis of pediatric onset gastrointestinal diseases, such as food protein-induced proctocolitis (FPIP), neonatal transient eosinophilic colitis (NTEC), Crohn’s disease (CD), and ulcerative colitis (UC), we examined the mucosal expression of inflammatory signals using microarray, RT-PCR, and immunohistochemical analysis. Enhanced expression of IL-6, CCL11, and CXCL13 was confirmed in both NTEC and FPIP. Mucosal infiltration of CD3- and IgA- but not IgE-positive cells was confirmed in both. Studies with CD and UC revealed that the expression of CXCL9, 10, 11 and MMP-1, -3, -7, -10 was significantly enhanced in active phase of pediatric CD and UC, respectively. Meanwhile, enhanced expression of CXCL13 was confirmed among these diseases suggested that IgA synthesis targeting multiple antigens is an important task for the mucosal immune systems during infancy since CXCL13 is a chemokine related to lymphoid follicle formation leading to IgA synthesis.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Antigen-specific T-cell responses in patients with non-IgE-mediated gastrointestinal food allergy are predominantly skewed to T(H)2.2012
Author(s)
Morita H, Nomura I, Orihara K, Yoshida K, Akasawa A, Tachimoto H, Ohtsuka Y, Namai Y, Futamura M, Shoda T, Matsuda A, Kamemura N, Kido H, Takahashi T, Ohya Y, Saito H, Matsumoto K.
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Journal Title
J Allergy Clin Immunol.
Volume: 131
Issue: 2
Pages: 590-2
DOI
Related Report
Peer Reviewed
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