| Project/Area Number |
24591586
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
本郷 賢一 東京慈恵会医科大学, 医学部, 准教授 (00256447)
角田 亘 東京慈恵会医科大学, 医学部, 准教授 (00453788)
草刈 洋一郎 東京慈恵会医科大学, 医学部, 講師 (80338889)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 右心不全 / 肺動脈 / ミトコンドリア / 右室肥大 / ラット / 肺動脈絞扼術 / bisoprolol / Autophagy |
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| Outline of Final Research Achievements |
We performed to estimate the effect of RV heart faiure in rats. A release of RV obstructive lesion is important to inhibit progress of fibrosis and brain mitochondrial damage. The progress of fibrosis, and mitochondrial dysfunction were inhibited by the amelioration of the cardiac function, but developed fibrosis was not restored. A PA debanding model might contribute to increased understanding molecular mechanism of the reversibility in heart failure.
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