| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Ninety-five children with rupture of mitral chordae tendineae were identified in nationwide surveys of Japan diagnosed from 1995 to 2013. Eighty-one (85%) patients were between 4 and 6 months of age. The underlying conditions included Kawasaki disease (10 cases), and maternally derived anti-SSA antibodies (2 cases). Surgery was performed in 80 patients (94 operations), and the final operations included plasty of mitral chordae in 52 cases and mechanical valve replacement in 26 cases. The histopathologic examinations (n=28) revealed inflammatory reactions with predominant mononuclear cell infiltration in 18 cases (64%). Eight patients (8.4%) died and significant neurological complications persisted in 10 cases (11%).
Acute heart failure attributable to rupture of the mitral chordae tendineae in infants should be recognized as a significant cardiovascular disorder that may cause sudden onset of cardiogenic shock and death in infants.
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