| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Nationwide survey was conducted on early-onset congenital long QT syndrome (LQTS), and revealed that patients who showed malignant clinical course with life-threatening ventricular tachycardia or atrioventricular block (AVB) were mostly those with LQTS type 2, 3, and 8. Functional 2:1 AVB was considered characteristic sign of malignant forms of early-onset LQTS. To save the lives of these patients, multiple-pharmacotherapy, including beta-blocker, sodium channel blocker (mexiletine) and magnesium, combined with pacemaker implantation is recommended.
We also analyzed the T-wave morphology on ECG by the newly-developed independent component analysis (ICA) as well as principal component analysis (PCA). Additional components which constitute the T wave were detected by ICA and a high PCA ratio (second/first eigenvector ratio) was obtained in patients with LQTS, indicating usefulness of ICA and PCA for diagnosis of LQTS.
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