| Project/Area Number |
24591603
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Yoshiki 香川大学, 医学部, 教授 (20116619)
MIKI Takanori 香川大学, 医学部, 教授 (30274294)
SUZUKI Shingo 香川大学, 医学部, 助教 (50451430)
WARITA Katsuhiko 香川大学, 医学部, 助教 (40452669)
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| Co-Investigator(Renkei-kenkyūsha) |
KUSAKA Takashi 香川大学, 医学部, 教授 (50274288)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 母子分離 / 神経回路網形成 / 海馬 / 樹状突起スパイン / 記憶・学習能 / BDNF / CaMKII / GluR1 / 学習障害 / 脳由来神経栄養因子 (BDNF) / 脳発達臨界期 / CaMKIIα / AMPA受容体 |
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| Outline of Final Research Achievements |
Present study showed that prolonged maternal separation influenced formation of neuronal circuit in the CA1 region of rat hippocampus and hippocampus-dependent learning ability after weaning. In addition, prolonged maternal separation caused the reduction of BDNF-ERK signaling and hyperphosphorylation of GluR1 via CaMKII in the rat hippocampus. Given that these factors are closely related to synaptic formation, functional synapses are commenced to be formed around postnatal days 7-10, these alterations possibly disrupt normal functional acquisition of brain development. Our findings suggest that prolonged maternal separation disturbs the factors related to synaptogenesis during early brain development, which might be in part responsible for abnormalities of formation of neuronal circuit and learning deficit in later life.
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