The assessment of the developmental prognosis of preterm infants by using diffusion tensor imaging
Project/Area Number |
24591605
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Embryonic/Neonatal medicine
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
MORIMOTO Masafumi 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (10285265)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 頭部MRI / 拡散強調画像 / 新生児 |
Outline of Final Research Achievements |
In this study, we evaluated the cerebellar and cerebral white matter (WM) of preterm infants with low-grade intraventricular hemorrhage (IVH) by diffusion tensor imaging (DTI). Using DTI tractography performed at term-equivalent age, we analyzed 42 infants who were born less than 30 weeks gestational age (GA) at birth (22 with low-grade IVH, 20 without). These infants were divided into two birth groups depending on GA, and we then compared the presence and absence of IVH in each group. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) at the superior cerebellar peduncle (SCP), middle cerebellar peduncle (MCP), motor tract, and sensory tract were measured. In the SCP, preterm born infants with IVH had lower FA values compared with infants without IVH. In particular, younger preterm birth with IVH had lower FA values in the SCP and motor tract, and higher ADC values in the MCP.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Low-grade intraventricular hemorrhage disrupts cerebellar white matter in preterm infants: evidence from diffusion tensor imaging2015
Author(s)
Takashi Morita, Masafumi Morimoto, Kei Yamada, Tatsuji Hasegawa, Shigemi Morioka, Satoshi Kidowaki, Masaharu Moroto, Satoshi Yamashita, Hiroshi Maeda, Tomohiro Chiyonobu, Sachiko Tokuda, Hajime Hosoi
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Journal Title
Neuroradiology
Volume: 57
Issue: 5
Pages: 507-514
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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