| Project/Area Number |
24591612
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SIODA Seiji 昭和大学, 医学部・顕微解剖学教室, 教授 (80102375)
SHIBATO Junko 昭和大学, 医学部・顕微解剖学教室, 研究員 (10611121)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | DOHaD / 網羅的遺伝子解析 / マウス / 新生児期栄養環境変化 / 自然免疫 / 遺伝子解析 / 新生児期栄養環境 / 発達障害 |
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| Outline of Final Research Achievements |
Although undernutrition during gestation is harmful for fetuses, calorie restriction is a strategy proven to extend healthy and maximum life span after birth. By focusing our attention on genes whose expression oppositely regulated between under- or high-nutrition during neonatal period, we selected candidate genes responsible for DOHaD. The results of microarray in C57BL mouse pup’s liver exposed to neonatal under- (50% food restriction) and high-nutrition (60% high fat food) demonstrated that innate immune system (Fos、Il1b、Rgs1、Ppp1r3g、Hamp、Igll1) was activated shortly after exposure. At weaning, expression of Aldhla 7 was decreased resulting of low resolution of acetaldehyde regardless of the nutritional conditions. By histopathological examination, abnormal development of immune tissues such as thymus and spleen was detected.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] A Study for collecting background data on Wistar Hannover [Crl:WI(Han)] rats in general toxicity studies - comparative data to Sprague Dawley rats2013
Author(s)
Hayakawa K, Mimura Y, Tachibana S, Furuya M, Kodama T, Aoki T, Hosokawa S, Fukui M, Shibata S, Yoshida M, Masuyama T, Narita T, Kuwagata M, Hisada S, Maki E.
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Journal Title
J Toxicol Sci.
Volume: 38
Pages: 855-873
NAID
Related Report
Peer Reviewed
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