| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
When basal keratinocytes migrate, adhesion between adhesive proteins including type XVII collagen (COL17) and extracellular matrix (ECM) needs to be dissociated; however, regulation mechanism of this adhesive molecule is not fully understood. In this study, we showed that expression of COL17 in basal keratinocytes may change depending on context dependent manner, and reduced COL17 expression is associated with migrating phenotype. In addition, increased laminin332 expression in the ECM was related with reduced migration of basal keratinocytes, suggesting interactions between COL17 and the ECM proteins are also important for correct migration of basal keratinocytes.
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