Pathogenic roles of collagen XVII in migration of basal keratinocytes
| Project/Area Number |
24591619
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Hokkaido University |
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Principal Investigator |
ITO Kei 北海道大学, 医学(系)研究科(研究院), 客員研究員 (20421977)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIE Wataru 北海道大学, 北海道大学病院, 講師 (20443955)
SHINKUMA Satoru 北海道大学, 大学院医学研究科, 助教 (00613788)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 皮膚病態学 / 皮膚生理学 |
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| Outline of Final Research Achievements |
When basal keratinocytes migrate, adhesion between adhesive proteins including type XVII collagen (COL17) and extracellular matrix (ECM) needs to be dissociated; however, regulation mechanism of this adhesive molecule is not fully understood. In this study, we showed that expression of COL17 in basal keratinocytes may change depending on context dependent manner, and reduced COL17 expression is associated with migrating phenotype. In addition, increased laminin332 expression in the ECM was related with reduced migration of basal keratinocytes, suggesting interactions between COL17 and the ECM proteins are also important for correct migration of basal keratinocytes.
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Report
(4 results)
Research Products
(7 results)
