Corneodesmosomal abnormality in skin barrier defects

• Project/Area Number: 24591620
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Asahikawa Medical College
• Principal Investigator: Ishida-Yamamoto Akemi 旭川医科大学, 医学部, 教授 (30241441)
• Research Collaborator: IGAWA Satomi ; Kwasi Teye Kurume University School of Medicine, Department of Dermatology
• Project Period (FY): 2012-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: デスモソーム / コルネオデスモソーム / 魚鱗癬 / アトピー性皮膚炎 / コルネオデスモシン / デスモグレイン / LEKTI / カリクレイン / ピーリングスキン病 / 角化細胞 / プロテアーゼ / タイトジャンクション / カリクレン

Outline of Final Research Achievements

Distribution patterns of desmosomal molecules in atopic dermatitis (AD) and related diseases (ichthyosis vulgaris, Netherton syndrome and the inflammation type peeling skin disease (IPSD)) were non-invasively analyzed. The characteristic pattern was obtained in each disease, and it seems to be a useful screening test for IPSD.
Gene analysis of an IPSD patient revealed a complete loss of the corneodesmosin gene due to a founder effect among Japanese patients.
The mechanism for thick AD stratum corneum was studied and incomplete secretion of a desquamation enzyme (KLK7) and increased expression of its inhibitor (LEKTI) were found.

Research Products

• [Journal Article] Desmosomes and corneodesmosomes and their relevance to genetic skin diseases (2017)
  • Author(s): Ishida-Yamamoto A, Kishibe M, Honma M
  • Journal Title: G Ital Dermatol Venereol Volume: 152 Issue: 2 Pages: 148-157
  • DOI: 10.23736/s0392-0488.16.05528-0
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Incomplete KLK7 Secretion and Upregulated LEKTI Expression Underlie Hyperkeratotic Stratum Corneum in Atopic Dermatitis (2017)
  • Author(s): Igawa S, Kishibe M, Minami-Hori M, Honma M, Tsujimura H, Ishikawa J, Fujimura T, Murakami M, Ishida-Yamamoto A
  • Journal Title: J Invest Dermatol Volume: 137 Issue: 2 Pages: 449-456
  • DOI: 10.1016/j.jid.2016.10.015
  • NAID: 120006473645
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Kallikrein-related peptidasesの炎症性皮膚疾患における役割 (2017)
  • Author(s): 飯沼晋、岸部麻里、本間大、山本明美
  • Journal Title: 臨床皮膚科 Volume: 71(5増） Pages: 46-49
  • Peer Reviewed
• [Journal Article] Corneodesmosin gene deletion is prevalent in Japanese patients with peeling skin disease: identification of 2 new cases. (2016)
  • Author(s): Teye K, Suga Y, Numata S, Ishii N, Krol RP, Ohata C, Matsuda M, Honma M, Ishida-Yamamoto A, Hamada T, Hashimoto T.
  • Journal Title: Journal of Dermatological Science Volume: 82 Issue: 2 Pages: 134-137
  • DOI: 10.1016/j.jdermsci.2016.01.012
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Erythrokeratodermia variabilis et progressiva (2016)
  • Author(s): Ishida-Yamamoto A
  • Journal Title: J Dermatol Volume: 43 Issue: 3 Pages: 280-285
  • DOI: 10.1111/1346-8138.13220
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A novel autosomal recessive mutation of DSG4 causes monilethrix through the ER stress response. (2015)
  • Author(s): Madoka Kato, Akira Shimizu, Yoko Yokoyama, Kyoichi Kaira, Yutaka Shimomura, Akemi Ishida-Yamamoto, Kiyoko Kamei, Fuminori Tokunaga, and Osamu Ishikawa
  • Journal Title: J. Invest. Dermatol. Volume: 135 Issue: 5 Pages: 1253-1260
  • DOI: 10.1038/jid.2015.12
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Klk8 is required for microabscess formation in a mouse imiquimod model of psoriasis. (2015)
  • Author(s): Iinuma S, Kishibe M, Saito N, Igawa S, Honma M, Takahashi H, Bando Y, Yoshida s, Iizuka H, Ishida-Yamamoto A.
  • Journal Title: Exp Dermatol Volume: 24 Issue: 11 Pages: 887-889
  • DOI: 10.1111/exd.12794
  • Peer Reviewed
• [Journal Article] Close correlation of herpes zoster-induced voiding dysfunction with severity of zoster-related pain: A single faculty retrospective study. (2015)
  • Author(s): Fujii M, Takahashi I, Honma M, Ishida-Yamamoto A.
  • Journal Title: J Dermatol Volume: 42 Issue: 11 Pages: 1091-1093
  • DOI: 10.1111/1346-8138.12957
  • Peer Reviewed
• [Journal Article] Accelerated nail elongation speed in psoriasis patients. (2015)
  • Author(s): Honma M, Iinuma S, Takahashi H, Iizuka H, Ishida-Yamamoto A.
  • Journal Title: The Journal of Dermatology Volume: 42 Issue: 9 Pages: 910-911
  • DOI: 10.1111/1346-8138.12990
  • Peer Reviewed
• [Journal Article] The biology and regulation of corneodesmosomes. (2015)
  • Author(s): Ishida-Yamamoto A, Igawa S.
  • Journal Title: Cell Tissue Res Volume: 360 Issue: 3 Pages: 477-482
  • DOI: 10.1007/s00441-014-2037-z
  • Peer Reviewed
• [Journal Article] Correlation of disease activity and serum level of carcinoembryonic antigen in acquired idiopathic generalized anhidrosis: A case report. (2015)
  • Author(s): Honma M, Iinuma S, Kanno K, Komatsu S, Minami-Hori M, Ishida-Yamamoto A.
  • Journal Title: J Dermatol. Volume: 42 Issue: 9 Pages: 900-902
  • DOI: 10.1111/1346-8138.12926
  • Peer Reviewed
• [Journal Article] Erythema multiforme-type drug eruption with prominent keratinocyte necrosis induced by long-term administration of telmisartan. (2015)
  • Author(s): Fujii M, Takahashi I, Kishiyama K, Honma M, Ishida-Yamamoto A.
  • Journal Title: J Dermatol. Volume: 42 Issue: 5 Pages: 537-9
  • DOI: 10.1111/1346-8138.12828
  • Peer Reviewed
• [Journal Article] Multiple poromas following combination chemotherapy and autologous peripheral blood stem cell transplantation. (2015)
  • Author(s): Takahashi C, Nishi K, Minami-Hori M, Kishibe M, Ishida-Yamamoto A, Iizuka H.
  • Journal Title: J Dermatol. Volume: 42 Issue: 4 Pages: 430-2
  • DOI: 10.1111/1346-8138.12794
  • Peer Reviewed
• [Journal Article] Squamous cell carcinoma in a chronic myelogenous leukemia patient treated with imatinib mesylate. (2015)
  • Author(s): Fujii M, Iwasaki T, Takahashi I, Kishiyama K, Honma M, Takahashi H, Ishida-Yamamoto A, Iizuka H.
  • Journal Title: J Dermatol. Volume: 42 Issue: 3 Pages: 338-9
  • DOI: 10.1111/1346-8138.12751
  • Peer Reviewed
• [Journal Article] Periorbital lupus profundus successfully treated with oral tacrolimus plus low-dose prednisolone. (2015)
  • Author(s): Minami-Hori M, Komatsu S, Komura K, Iizuka H, Ishida-Yamamoto A.
  • Journal Title: J Dermatol. Volume: 42 Issue: 2 Pages: 222-3
  • DOI: 10.1111/1346-8138.12742
  • NAID: 120005690951
  • Peer Reviewed
• [Journal Article] The biology and regulation of corneodesmosomes. (2015)
  • Author(s): Ishida-Yamamoto A, Igawa S.
  • Journal Title: Cell Tissue Res. Volume: 360
  • Peer Reviewed
• [Journal Article] Epithelial Inflammation Resulting from an Inherited Loss-of-Function Mutation in EGFR. (2014)
  • Author(s): Campbell P, Morton P, Takeichi T, Salam A, Roberts N, Proudfoot LE, Mellerio JE, Aminu K, Wellington C, Patil SN, Akiyama M, Liu L, McMillan JR, Aristodemou S, Ishida-Yamamoto A, Abdul-Wahab A, Petrof G, Fong K, Harnchoowong S, Stone K, Harper JI, McLean WH, Simpson MA, Parsons M, McGrath JA.
  • Journal Title: J Invest Dermatol Volume: [Epub ahead of print] Issue: 10 Pages: 2570-8
  • DOI: 10.1038/jid.2014.164
  • Peer Reviewed / Open Access
• [Journal Article] Cutaneous necrotizing vasculitis as a manifestation of familial Mediterranean fever. (2014)
  • Author(s): Komatsu S, Honma M, Igawa S, Tsuji H, Ishida-Yamamoto A, Migita K, Ida H, Iizuka H.
  • Journal Title: J Dermatol. Volume: 41 Issue: 9 Pages: 827-9
  • DOI: 10.1111/1346-8138.12588
  • Peer Reviewed / Open Access
• [Journal Article] IL36RN Mutations Underlie Impetigo Herpetiformis (2014)
  • Author(s): Sugiura K, Oiso N, Iinuma S, Matsuda H, Minami-Hori M, Ishida-Yamamoto A, Kawada A, Iizuka H, Akiyama M
  • Journal Title: J Invest Dermatol Volume: 134 Issue: 9 Pages: 2472-2474
  • DOI: 10.1038/jid.2014.177
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function. (2014)
  • Author(s): Brooke MA, Etheridge SL, Kaplan N, Simpson C, O'Toole EA, Ishida-Yamamoto A, Marches O, Getsios S, Kelsell DP.
  • Journal Title: Hum Mol Genet. Volume: 23 Issue: 15 Pages: 4064-76
  • DOI: 10.1093/hmg/ddu120
  • Peer Reviewed / Open Access
• [Journal Article] Cutaneous lesions of Kikuchi's disease: evolution of histopathological findings. (2014)
  • Author(s): Kanno K, Minami-Hori M, Ishida-Yamamoto A, Komura K, Oikawa K, Miyokawa N, Iizuka H.
  • Journal Title: J Dermatol. Volume: 41 Issue: 8 Pages: 736-8
  • DOI: 10.1111/1346-8138.12557
  • Peer Reviewed / Open Access
• [Journal Article] Genetic skin diseases related to desmosomes and corneodesmosomes (2014)
  • Author(s): Ishida-Yamamoto A, Igawa S
  • Journal Title: J Dermatol Sci Volume: 74 Issue: 2 Pages: 99-105
  • DOI: 10.1016/j.jdermsci.2014.02.005
  • NAID: 120005530879
  • Peer Reviewed / Open Access
• [Journal Article] Vesicular LL-37 contributes to inflammation of the lesional skin of palmoplantar pustulosis. (2014)
  • Author(s): Murakami M, Kaneko T, Nakatsuji T, Kameda K, Okazaki H, Dai X, Hanakawa Y, Tohyama M, Ishida-Yamamoto A, Sayama K.
  • Journal Title: PLoS One. Volume: 9 Issue: 10 Pages: 304-311
  • DOI: 10.1371/journal.pone.0110677
  • Peer Reviewed / Open Access
• [Journal Article] Inflammatory peeling skin syndrome caused by homozygous genomic deletion in the PSORS1 region encompassing the CDSN gene (2014)
  • Author(s): Akemi Ishida-Yamamoto, Laetitia Furio, Satomi Igawa, Masaru Honma,Elodie Tron, Valerie Malan, Masamoto Murakami, Alain Hovnanian
  • Journal Title: Exp Dermatol Volume: 23 Issue: 1 Pages: 60-63
  • DOI: 10.1111/exd.12292
  • Peer Reviewed
• [Journal Article] iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function (2014)
  • Author(s): Brooke MA, Etheridge SL, Kaplan N, Simpson C, O'Toole EA, Ishida-Yamamoto A, Marches O, Getsios S, Kelsell DP
  • Journal Title: Hum Mol Genet Volume: [Epub ahead of print]
  • Peer Reviewed
• [Journal Article] Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting (2013)
  • Author(s): Samuelov L, Sarig O, Harmon RM, Rapaport D, Ishida-Yamamoto A, Isakov O, Koetsier JL, Gat A, Goldberg I, Bergman R, Spiegel R, Eytan O, Geller S, Peleg S, Shomron N, Goh CS, Wilson NJ, Smith FJ, Pohler E, Simpson MA, McLean WH, Irvine AD, Horowitz M, McGrath JA, Green KJ, Sprecher E
  • Journal Title: Nat Genet Volume: 45 Issue: 10 Pages: 1244-1248
  • DOI: 10.1038/ng.2739
  • Peer Reviewed
• [Journal Article] Aberrant distribution patterns of corneodesmosomal components of tape-stripped corneocytes in atopic dermatitis and related skin conditions (ichthyosis vulgaris, Netherton syndrome and peeling skin syndrome type B). (2013)
  • Author(s): Igawa S, Kishibe M, Honma M, Murakami M, Mizuno Y, Suga Y, Seishima M, Ohguchi Y, Akiyama M, Hirose K, Ishida-Yamamoto A, Iizuka H.
  • Journal Title: J Dermatol Sci Volume: 72 Issue: 1 Pages: 54-60
  • DOI: 10.1016/j.jdermsci.2013.05.004
  • Peer Reviewed
• [Journal Article] A phase II randomized vehicle-controlled trial of intradermal allogeneic fibroblasts for recessive dystrophic epidermolysis bullosa (2013)
  • Author(s): Venugopal SS, Yan W, Frew JW, Cohn HI, Rhodes LM, Tran K, Melbourne W, Nelson JA, Sturm M, Fogarty J, Marinkovich MP, Igawa S, Ishida-Yamamoto A, Murrell DF
  • Journal Title: J Am Acad Dermatol Volume: 69 Issue: 6 Pages: 898-908
  • DOI: 10.1016/j.jaad.2013.08.014
  • Peer Reviewed
• [Journal Article] Cole Disease Results from Mutations in ENPP1 (2013)
  • Author(s): Eytan O, Morice-Picard F, Sarig O, Ezzedine K, Isakov O, Li Q, Ishida-Yamamoto A, Shomron N, Goldsmith T, Fuchs-Telem D, Adir N, Uitto J, Orlow SJ, Taieb A, Sprecher E
  • Journal Title: Am J Hum Genet Volume: 93 Issue: 4 Pages: 752-7
  • DOI: 10.1016/j.ajhg.2013.08.007
  • Peer Reviewed
• [Journal Article] A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis (2013)
  • Author(s): Sasaki T, Shiohama A, Kubo A, Kawasaki H, Ishida-Yamamoto A, Yamada T, Hachiya T, Shimizu A, Okano H, Kudoh J, Amagai M
  • Journal Title: J Allergy Clin Immunol Volume: 132 Issue: 5 Pages: 1111-1120
  • DOI: 10.1016/j.jaci.2013.08.027
  • Peer Reviewed
• [Journal Article] Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis syndrome is caused by a POC1A mutation (2012)
  • Author(s): Sarig O, Nahum S, Rapaport D, Ishida-Yamamoto A, et al.
  • Journal Title: Am J Hum Genet Volume: 91 Issue: 2 Pages: 337-342
  • DOI: 10.1016/j.ajhg.2012.06.003
  • Peer Reviewed
• [Journal Article] Over-Expression of Kallikrein Related Peptidases in Palmoplantar Pustulosis (2012)
  • Author(s): Kaneko T et al.
  • Journal Title: J Dermatol Sci Volume: 67 Issue: 1 Pages: 73-76
  • DOI: 10.1016/j.jdermsci.2012.03.009
  • Peer Reviewed
• [Journal Article] Kallikrein-related peptidase 8-dependent skin wound healing is associated with upregulation of kallikrein-related peptidase 6 and PAR2 (2012)
  • Author(s): Kishibe M, Bando Y, Tanaka T, Ishida-Yamamoto A, Iizuka H, Yoshida S
  • Journal Title: J Invest Dermatol Volume: (印刷中) Issue: 6 Pages: 1717-1724
  • DOI: 10.1038/jid.2012.18
  • Peer Reviewed
• [Journal Article] Tight junction-related multilayered network structures in mammalian epidermis. (2012)
  • Author(s): Ishida-Yamamoto A, Kishibe M, Murakami M, Honma M, Takahashi H, Iizuka H.
  • Journal Title: PLoS ONE Volume: 7 Issue: 2 Pages: 1-7
  • DOI: 10.1371/journal.pone.0031641
  • Peer Reviewed
• [Journal Article] Expression profile of cornified envelope structural proteins and keratinocyte differentiation-regulating proteins during skin barrier repair (2012)
  • Author(s): de Koning HD, van den Bogaard EH, Bergboer JG, Kamsteeg M, van Vlijmen-Willems IM, Hitomi K, Henry J, Simon M, Takashita N, Ishida-Yamamoto A, et al.
  • Journal Title: Br J Dermatol Volume: 166 Issue: 6 Pages: 1245-1254
  • DOI: 10.1111/j.1365-2133.2012.10885.x
  • Peer Reviewed
• [Presentation] 小児の皮膚バリア障害 (2017)
  • Author(s): 山本明美
  • Organizer: 第80回日本皮膚科学会東京支部学術大会
  • Place of Presentation: パシフィコ横浜、横浜市
  • Year and Date: 2017-02-11
  • Invited
• [Presentation] Desmosome Pathology in Ichthyosis (2016)
  • Author(s): Akemi Ishida-Yamamoto
  • Organizer: Asian Dermatology Congress 2016
  • Place of Presentation: Mumbai, India
  • Year and Date: 2016-10-13
  • Int'l Joint Research / Invited
• [Presentation] Lamellar granule secretory system in normal and diseased skin (2016)
  • Author(s): Akemi Ishida-Yamamoto
  • Organizer: 7th annual meeting of pan Asian-Paciffic skin barrier research society Kunming 2016
  • Place of Presentation: Yun'an Conference Resort, Kunming, China
  • Year and Date: 2016-07-21
  • Int'l Joint Research / Invited
• [Presentation] Update on syndromic ichthyosis (2016)
  • Author(s): Akemi Ishida-Yamamoto
  • Organizer: 23ed World Congress of Dermatology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2016-06-11
  • Int'l Joint Research / Invited
• [Presentation] Corneodesmosome degradation is disturbed in stratum corneum of atopic dermatitis lesional skin in spite of kallikrein 7 over-expression (2015)
  • Author(s): Satomi Igawa, Mari Kishibe, Takashi Shibuya, Nao Saito, Shin Iizuma, Masaru Honma, Akemi Ishida-Yamamoto
  • Organizer: The 40th annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Okayama Convention Center, Okayama
  • Year and Date: 2015-11-11
• [Presentation] A novel PIPK1 function in human epidermal inflammatin and keratinization (2015)
  • Author(s): Nao Saito, Masaru Honma, Takashi Shibuya, Satomi Igawa, Mari Kishibe, Akemi Ishida-Yamamoto
  • Organizer: he 40th annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Okayama Convention Center, Okayama
  • Year and Date: 2015-11-11
• [Presentation] わかりやすい表皮のバリア構造とアトピー性皮膚炎・魚鱗癬 (2015)
  • Author(s): 山本明美
  • Organizer: 第２０回スキンケア研究会
  • Place of Presentation: ホテルアソシア静岡
  • Year and Date: 2015-02-05
  • Invited
• [Presentation] Netherton症候群と類症 (2014)
  • Author(s): 山本明美
  • Organizer: 第７８回日本皮膚科学会東部支部総会
  • Place of Presentation: ホテル青森
  • Year and Date: 2014-10-04 – 2014-10-05
  • Invited
• [Presentation] 機能的視点から見た角層の構造 (2014)
  • Author(s): 山本明美
  • Organizer: 第１１３回日本皮膚科学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2014-05-30 – 2014-06-01
  • Invited
• [Presentation] Epidermal lamellar granule secretion starts before the establishment of intercellular permeability barrier (2013)
  • Author(s): A. Ishida-Yamamoto, S. Igawa S, M. Kishibe, H. Iizuka
  • Organizer: 40th Annual Meeting of SCUR-6th Joint Meeting with SSSR
  • Place of Presentation: Castellani Park Hotel, Sarzburg, Austria
• [Presentation] Kallikrein 7 is increased, but only partially activated in atopic dermatitis corneocytes (2013)
  • Author(s): Satomi Igawa, Mari Kishibe, Masako Minami-Hori, Masamoto Murakami, Akemi Ishida-Yamamoto, Hajime Iizuka
  • Organizer: International Investigative Dermatology
  • Place of Presentation: Edinburgh International Conference Centre, Edingurgh, UK
• [Presentation] 「魚鱗癬紋理」を診る (2013)
  • Author(s): 山本明美
  • Organizer: 第112回日本皮膚科学会総会 教育講演20
  • Place of Presentation: パシフィコ横浜、横浜市、神奈川県
  • Invited
• [Presentation] よくわかる電顕の基本演習 (2013)
  • Author(s): 山本明美
  • Organizer: 第112回日本皮膚科学会総会 教育講演45
  • Place of Presentation: パシフィコ横浜、横浜市、神奈川県
  • Invited
• [Presentation] 皮膚剥離酵素とその異常症 (2013)
  • Author(s): 山本明美
  • Organizer: 第112回日本皮膚科学会総会 教育講演48
  • Place of Presentation: パシフィコ横浜、横浜市、神奈川県
  • Invited
• [Presentation] Epidermal lamellar granule secretion starts before the establishment of intercellular permeability barrier (2013)
  • Author(s): A. Ishida-Yamamoto, S. Igawa S, M. Kishibe, H. Iizuka
  • Organizer: 40th Annual Meeting of SSSR-6th Joint Meeting with SSSR
  • Place of Presentation: Castellani Park Hotel, Sarzburg, Austria
• [Presentation] A desquamation paradox of atopic dermatitis - Markedly ramaining corneodesmosomes despite the increased serine protease activity in vitro (2012)
  • Author(s): Igawa Satomi, Ishida-Yamamoto Akemi, et al.
  • Organizer: The 37th annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Loisir Hotel, Okinawa, Japan
• [Presentation] 表皮バリア構造とその異常症
  • Author(s): 山本明美
  • Organizer: 愛媛皮膚セミナー
  • Place of Presentation: リジェール松山
  • Invited
• [Presentation] 表皮の細胞間接着構造の基礎 電顕でみるときのコツ
  • Author(s): 山本明美
  • Organizer: 第39回皮膚かたち研究学会
  • Place of Presentation: ３階講堂, 東京慈恵会医科大学, 東京都
  • Invited
• [Presentation] 皮膚バリア構造に関する私見、とくに表皮タイトジャンクションについて
  • Author(s): 山本明美
  • Organizer: 皮膚基礎研究クラスターフォーラム
  • Place of Presentation: タワーホール船堀、東京都
  • Invited
• [Book] 美肌科学の最前線 (2014)
  • Author(s): 山本明美、井川哲子
  • Total Pages: 271
  • Publisher: シーエムシー出版、東京都
• [Remarks] 研究者詳細
  • URL: http://hyouka04.asahikawa-med.ac.jp/html/100000085_ja.html
• [Remarks] 旭川医科大学皮膚科学講座 研究業績 過去の業績
  • URL: http://www.asahikawa-med.ac.jp/dept/mc/dermat/gyouseki.html
• [Remarks] 旭川医科大学 研究者総覧
  • URL: http://hyouka04.asahikawa-med.ac.jp/html/100000085_ja.html
• [Remarks] 旭川医科大学皮膚科
  • URL: http://www.asahikawa-med.ac.jp/dept/mc/dermat/
• [Remarks] 国立大学法人旭川医科大学 研究者詳細
  • URL: http://202.243.18.98/html/100000085_ja.html