| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Distribution patterns of desmosomal molecules in atopic dermatitis (AD) and related diseases (ichthyosis vulgaris, Netherton syndrome and the inflammation type peeling skin disease (IPSD)) were non-invasively analyzed. The characteristic pattern was obtained in each disease, and it seems to be a useful screening test for IPSD.
Gene analysis of an IPSD patient revealed a complete loss of the corneodesmosin gene due to a founder effect among Japanese patients.
The mechanism for thick AD stratum corneum was studied and incomplete secretion of a desquamation enzyme (KLK7) and increased expression of its inhibitor (LEKTI) were found.
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