| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
Total loss of Cathepsin C ( CTSC ) activity cause Papillon-Lefevre syndrome ( PLS ), which characterized by palmoplantar keratoderma ( PPK ). CTSC knock out mice naturaly lack PPK, so we examined whether inflammation trigger a change of epidermal differentitation in CTSC knock out mice. We made four groups, knock out mice and wild type mice with or without application of TPA. We confirmed that knock out mice with application of TPA had feeature of palmplanterkeratosis,remarkable hyperkeratosis and acanthosis histologically.
This research sugesut that skin manifestation of Pappilion Lefevre syndrome caused by irritation,so skin change localize palmplanter,knee,elbow in PLS.
|
