Factors inhibit serine protease activity and echance epidermal differentiation in Papillon-Lefevre syndrome
Project/Area Number |
24591621
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
|
Research Institution | Hirosaki University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
NAKANO Hajime 弘前大学, 大学院医学研究科, 准教授 (90281922)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | cathepsin C / inflamation / hyperkeratosis / acanthosis / カテプシンC / パピヨン・ルフェーブル症候群 / セリンプロテアーゼ / 過角化 / 外的刺激 |
Outline of Final Research Achievements |
Total loss of Cathepsin C ( CTSC ) activity cause Papillon-Lefevre syndrome ( PLS ), which characterized by palmoplantar keratoderma ( PPK ). CTSC knock out mice naturaly lack PPK, so we examined whether inflammation trigger a change of epidermal differentitation in CTSC knock out mice. We made four groups, knock out mice and wild type mice with or without application of TPA. We confirmed that knock out mice with application of TPA had feeature of palmplanterkeratosis,remarkable hyperkeratosis and acanthosis histologically. This research sugesut that skin manifestation of Pappilion Lefevre syndrome caused by irritation,so skin change localize palmplanter,knee,elbow in PLS.
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Report
(4 results)
Research Products
(10 results)