Research Project
Grant-in-Aid for Scientific Research (C)
in order to how the innate immune system affect skin inflammatory disease, we examined how cathelicidin affect human epidermal keratinocytes and inflammatory cell in this study. We identified IL-36s, IL-1 family molecules, are induced by the cathelicidin peptide stimulation in human keratinocytes. Cathelicidin and IL-36s are additively or synergisticcally induced inflammatory cytokines in human keratinocytes. We also observed that cathelicidin and IL-36s are coordinately expressed in the lesional epidermis of the psoriasis, a chronic skin inflammatory diseases. These suggested that cathelicidin and IL-36s exacerbate human skin diseases such as psoriasis.
All 2014 2013 2012
All Journal Article (6 results) (of which Peer Reviewed: 6 results, Acknowledgement Compliant: 1 results) Presentation (1 results)
J Immunol
Volume: 193 Issue: 10 Pages: 5140-8
10.4049/jimmunol.1302574
Cell Host and Microbe
Volume: 13 Issue: 1 Pages: 77-86
10.1016/j.chom.2012.12.002
J Invest Dermatol
Volume: 133 Issue: 10 Pages: 2407-15
10.1038/jid.2013.163
Volume: 133 Issue: 4 Pages: 988-998
10.1038/jid.2012.437
Volume: 132 Issue: 1 Pages: 135-143
10.1038/jid.2011.259
J Allergy Clin Immunol
Volume: 130 Issue: 1 Pages: 259-261
10.1016/j.jaci.2012.03.006
130004505789