Elucidation of the mechanism by which pemphigus vulgaris autoantibodies cause cellular signaling in human keratinocytes
| Project/Area Number |
24591634
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGAMI Jun 慶應義塾大学, 医学部, 講師 (80327618)
AMAGAI Masayuki 慶応義塾大学, 医学部, 教授 (90212563)
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| Research Collaborator |
KOWALCZYK AP 米国エモリー大学, 医学部, 准教授
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 尋常性天疱瘡 / デスモゾーム / 脂質ラフト / 細胞内シグナル / 国際情報交換 / 米国 / アトランタ / 天疱瘡 |
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| Outline of Final Research Achievements |
It was shown that desmosomal proteins are biochemically associated with lipid rafts on the human keratinocyte cell membrane. Furthermore, lipid rafts are considered to be an significant platform for both assembly and disassembly of desmosomes. It was also demonstrated that anti-desmoglein (Dsg) 3 autoantibodies in the sera of pemphigus vulgaris patients cause clustering of Dsg3 on the cell surface, and the clustered Dsg3 molecules are to be internalized in a both lipid raft-dependent and cellular signaling-dependent manner.
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Report
(4 results)
Research Products
(2 results)
